ChemicalBook > CAS DataBase List > Pirarubicin

Pirarubicin

Product Name: Pirarubicin
CAS No.: 72496-41-4
Chemical Name: Pirarubicin
Synonyms: Therarubicin;PIRARUBICIN HYDROCHLORIDE;(8S,10S)-10-[(2S,4S,5S,6S)-4-Amino-6-methyl-5-[(2S)-oxan-2-yl]oxy-oxan-2-yl]oxy-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-9,10-dihydro-7H-tetracene-5,12-dione;(8S,10S)-10-[[3-Amino-2,3,6-trideoxy-4-O-[(2R)-tetrahydro-2H-pyran-2-yl]-a-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,12-naphthacenedione;CS-702;1609rb;THP-ADM;Pirabucin;Pirarubcin;THEPRUBICIN
CBNumber: CB7315796
Molecular Formula: C32H37NO12
Formula Weight: 627.64
MOL File: 72496-41-4.mol

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Pirarubicin Property

Melting point:: 188-192°C (dec.)
alpha: D25 +175 ±25° (c = 0.2 in CHCl3)
Boiling point:: 834.7±65.0 °C(Predicted)
Density: 1.51±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: ethanol: soluble25mg/mL
form: powder
pka: 7.35±0.60(Predicted)
color: Orange to Red
Stability:: Hygroscopic
InChIKey: KMSKQZKKOZQFFG-YXRRJAAWSA-N
SMILES: C1=C(OC)C2C(=O)C3=C(O)C4[C@@H](O[C@@H]5O[C@@H](C)[C@@H](O[C@H]6OCCCC6)[C@@H](N)C5)C[C@](O)(C(CO)=O)CC=4C(O)=C3C(=O)C=2C=C1

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39
WGK Germany: 3
RTECS: QI9296000
Toxicity: LD50 i.v. in mice: 27.8 mg/kg (Umezawa, 1979)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H340May cause genetic defects

H350May cause cancer

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P8624
Product name: Pirarubicin
Purity: ≥95% (HPLC)
Packaging: 10mg
Price: $432
Updated: 2023/06/20

Sigma-Aldrich

Product number: P8624
Product name: Pirarubicin
Purity: ≥95% (HPLC)
Packaging: 25mg
Price: $863
Updated: 2023/06/20

Cayman Chemical

Product number: 28384
Product name: Pirarubicin
Packaging: 10mg
Price: $84
Updated: 2024/03/01

Cayman Chemical

Product number: 28384
Product name: Pirarubicin
Packaging: 100mg
Price: $638
Updated: 2024/03/01

Cayman Chemical

Product number: 28384
Product name: Pirarubicin
Packaging: 5mg
Price: $44
Updated: 2024/03/01

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Pirarubicin Chemical Properties,Usage,Production

Description

Pirarubicin is a new anthracycline anticancer agent structurally related to doxorubicin. In acute leukemia, non-Hodgkin’s lymphoma, breast and ovariail carcinoma, pirarubicin is reportedly superior to doxorubicin and better tolerated. Its major side-effect appears to be myelosuppression, mainly in the form of leucopenia, which is potentially dose-limiting.

Chemical Properties

Red Solid

Originator

Meiji Seika (Japan)

Uses

Structural analog of Doxorubicin. Antineoplastic.

Definition

ChEBI: (7S,9S)-7-[[(2R,4S,5S,6S)-4-amino-6-methyl-5-[[(2R)-2-oxanyl]oxy]-2-oxanyl]oxy]-6,9,11-trihydroxy-9-(2-hydroxy-1-oxoethyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione is an anthracycline.

brand name

Pinorubicin; Therarubucin

Pirarubicin Preparation Products And Raw materials

Raw materials

Doxorubicin hydrochloride Adriamycin Silica gel Tetrahydropyran

Preparation Products

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Pirarubicin Suppliers

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View Lastest Price from Pirarubicin manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: Pirarubicin 72496-41-4
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-19

Moxin Chemicals

Product: Pirarubicin Impurity 1 72496-41-4
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 95%+
Supply Ability: 10000
Release date: 2025-01-21

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Product: Pirarubicin 72496-41-4
Price: US $0.00/g
Min. Order: 1g
Purity: More Than 99%
Supply Ability: 100kg/Month
Release date: 2024-10-11

72496-41-4, PirarubicinRelated Search:

Doxorubicinone Chrysophanic acid Idarubicin hydrochloride Adriamycin 2-(HYDROXYMETHYL)ANTHRAQUINONE Pirarubicin 1,8-Dihydroxyanthraquinone 1,2,3,4-TETRAHYDRO-1,5-NAPHTHALENEDIOL 3,4-DIMETHYL-3'-METHOXYBENZOPHENONE 2-METHOXY-4'-METHYLBENZOPHENONE 2-METHOXY-3'-METHYLBENZOPHENONE 14-Hydroxy Carminomycin 2,4-DIMETHYL-3'-METHOXYBENZOPHENONE Carubicin 4-ETHYL-2'-METHOXYBENZOPHENONE L-DaunosamineHCl 3-METHOXY-3'-METHYLBENZOPHENONE ISLANDICIN

THP-ADM

THEPRUBICIN

(8s-cis)-droxyacetyl)-1-methoxy

(8S,10S)-10-[[3-Amino-2,3,6-trideoxy-4-O-[(2R)-tetrahydro-2H-pyran-2-yl]-a-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,12-naphthacenedione

Tepirubicin

Therarubiein

THP-adriamycin

(8S,10S)-10-[(2S,4S,5S,6S)-4-Amino-6-methyl-5-[(2S)-oxan-2-yl]oxy-oxan-2-yl]oxy-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-9,10-dihydro-7H-tetracene-5,12-dione

5,12-Naphthacenedione, 10-((3-amino-2,3,6-trideoxy-4-O-(tetrahydro-2H-pyran-2-yl)-alpha-L- lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, (8S-cis)-

(8S)-10α-[[3-Amino-2,3,6-trideoxy-4-O-(tetrahydro-2H-pyran-2-yl)-α-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8β-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione

(8S,10S)-10α-[[3-Amino-4-O-(tetrahydro-2H-pyran-2-yl)-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8β-hydroxyacetyl-1-methoxy-5,12-naphthacenedione

Pirarubicin(THP-AdriaMycin)

(7S,9S)-7-((2R,4S,5S,6S)-4-amino-6-methyl-5-((R)-tetrahydro-2H-pyran-2-yloxy)-tetrahydro-2H-pyran-2-yloxy)-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione

PIRARUBICIN

PIRARUBICIN HYDROCHLORIDE

CS-702

Pirarubcin

1609rb

4’-o-tetrahydropyranyladriamycin

4’-o-tetrahydropyranyldoxorubicin

5,12-naphthacenedione,10-((3-amino-2,3,6-trideoxy-4-o-(tetrahydro-2h-pyran-2-y

l)-alpha-l-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hy

Pirarubicin(BICINS)

(8S,10S)-10-[[3-Amino-2,3,6-trideoxy-4-O-[(2R)-tetrahydro-2H-pyran-2-yl]-α-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,12-naphthacenedione

Pinorubicin

Therarubicin

Pirabucin

5,12-Naphthacenedione, 10-3-amino-2,3,6-trideoxy-4-O-(2R)-tetrahydro-2H-pyran-2-yl-.alpha.-L-lyxo-hexopyranosyloxy-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, (8S,10S)-

(8S)-10-[(2S,4S,5S,6S)-4-amino-6-methyl-5-[(2R)-oxan-2-yl]oxy-oxan-2-yl]oxy-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-9,10-dihydro-7H-tetracene-5,12-dione

5,12-Naphthacenedione, 10-[[3-amino-2,3,6-trideoxy-4-O-[(2R)-tetrahydro-2H-pyran-2-yl]-α-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-, (8S,10S)-

Pirarubicin USP/EP/BP

(8S,10S)-10-(((2R,4S,5S,6S)-4-Amino-6-methyl-5-(((R)-tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione

Pirarubicin Topoisomerase II inhibitor ab142734

THP-Doxorubicin

Theprubicin|||THP

Famoxadone Impurity 14

Pirarubicin, Topoisomerase II inhibitor

Pirarubicin, 10 mM in DMSO

(8s,10s)-10-(((2r,4s,5s,6s)-4-amino-6-methyl-5-(((s)-tetrahydro-2h-pyran-2-yl)oxy)tetrahydro-2h-pyran-2-yl)oxy)-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione

72496-41-4

58479-32-8

C32H37NO12

Inhibitors

API

Intermediates & Fine Chemicals

Pharmaceuticals

Chiral Reagents