ChemicalBook > CAS DataBase List > Pirarubicin

Pirarubicin

Product Name
Pirarubicin
CAS No.
72496-41-4
Chemical Name
Pirarubicin
Synonyms
Therarubicin;PIRARUBICIN HYDROCHLORIDE;(8S,10S)-10-[(2S,4S,5S,6S)-4-Amino-6-methyl-5-[(2S)-oxan-2-yl]oxy-oxan-2-yl]oxy-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-9,10-dihydro-7H-tetracene-5,12-dione;(8S,10S)-10-[[3-Amino-2,3,6-trideoxy-4-O-[(2R)-tetrahydro-2H-pyran-2-yl]-a-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,12-naphthacenedione;CS-702;1609rb;THP-ADM;Pirabucin;Pirarubcin;THEPRUBICIN
CBNumber
CB7315796
Molecular Formula
C32H37NO12
Formula Weight
627.64
MOL File
72496-41-4.mol
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Pirarubicin Property

Melting point:
188-192°C (dec.)
alpha 
D25 +175 ±25° (c = 0.2 in CHCl3)
Boiling point:
834.7±65.0 °C(Predicted)
Density 
1.51±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
ethanol: soluble25mg/mL
form 
powder
pka
7.35±0.60(Predicted)
color 
Orange to Red
Stability:
Hygroscopic
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-37/39
WGK Germany 
3
RTECS 
QI9296000
Toxicity
LD50 i.v. in mice: 27.8 mg/kg (Umezawa, 1979)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H340May cause genetic defects

H350May cause cancer

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P8624
Product name
Pirarubicin
Purity
≥95% (HPLC)
Packaging
10mg
Price
$432
Updated
2023/06/20
Sigma-Aldrich
Product number
P8624
Product name
Pirarubicin
Purity
≥95% (HPLC)
Packaging
25mg
Price
$863
Updated
2023/06/20
Cayman Chemical
Product number
28384
Product name
Pirarubicin
Packaging
10mg
Price
$84
Updated
2024/03/01
Cayman Chemical
Product number
28384
Product name
Pirarubicin
Packaging
100mg
Price
$638
Updated
2024/03/01
Cayman Chemical
Product number
28384
Product name
Pirarubicin
Packaging
5mg
Price
$44
Updated
2024/03/01
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Pirarubicin Chemical Properties,Usage,Production

Description

Pirarubicin is a new anthracycline anticancer agent structurally related to doxorubicin. In acute leukemia, non-Hodgkin’s lymphoma, breast and ovariail carcinoma, pirarubicin is reportedly superior to doxorubicin and better tolerated. Its major side-effect appears to be myelosuppression, mainly in the form of leucopenia, which is potentially dose-limiting.

Chemical Properties

Red Solid

Originator

Meiji Seika (Japan)

Uses

Structural analog of Doxorubicin. Antineoplastic.

Definition

ChEBI: (7S,9S)-7-[[(2R,4S,5S,6S)-4-amino-6-methyl-5-[[(2R)-2-oxanyl]oxy]-2-oxanyl]oxy]-6,9,11-trihydroxy-9-(2-hydroxy-1-oxoethyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione is an anthracycline.

brand name

Pinorubicin; Therarubucin

Pirarubicin Preparation Products And Raw materials

Raw materials

Doxorubicin hydrochloride Adriamycin Silica gel Tetrahydropyran

Preparation Products

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View Lastest Price from Pirarubicin manufacturers

Moxin Chemicals
Product
Pirarubicin Impurity 1 72496-41-4
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
95%+
Supply Ability
10000
Release date
2025-01-21
Hebei Mujin Biotechnology Co.,Ltd
Product
Pirarubicin 72496-41-4
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-07-03
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Product
Pirarubicin 72496-41-4
Price
US $0.00/g
Min. Order
1g
Purity
More Than 99%
Supply Ability
100kg/Month
Release date
2024-10-11

72496-41-4, PirarubicinRelated Search:

Doxorubicinone Chrysophanic acid Idarubicin hydrochloride Adriamycin 2-(HYDROXYMETHYL)ANTHRAQUINONE Pirarubicin 1,8-Dihydroxyanthraquinone 1,2,3,4-TETRAHYDRO-1,5-NAPHTHALENEDIOL 3,4-DIMETHYL-3'-METHOXYBENZOPHENONE 2-METHOXY-4'-METHYLBENZOPHENONE 2-METHOXY-3'-METHYLBENZOPHENONE 14-Hydroxy Carminomycin 2,4-DIMETHYL-3'-METHOXYBENZOPHENONE Carubicin 4-ETHYL-2'-METHOXYBENZOPHENONE L-DaunosamineHCl 3-METHOXY-3'-METHYLBENZOPHENONE ISLANDICIN

  • THP-ADM
  • THEPRUBICIN
  • (8s-cis)-droxyacetyl)-1-methoxy
  • (8S,10S)-10-[[3-Amino-2,3,6-trideoxy-4-O-[(2R)-tetrahydro-2H-pyran-2-yl]-a-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,12-naphthacenedione
  • Tepirubicin
  • Therarubiein
  • THP-adriamycin
  • (8S,10S)-10-[(2S,4S,5S,6S)-4-Amino-6-methyl-5-[(2S)-oxan-2-yl]oxy-oxan-2-yl]oxy-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-9,10-dihydro-7H-tetracene-5,12-dione
  • 5,12-Naphthacenedione, 10-((3-amino-2,3,6-trideoxy-4-O-(tetrahydro-2H-pyran-2-yl)-alpha-L- lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, (8S-cis)-
  • (8S)-10α-[[3-Amino-2,3,6-trideoxy-4-O-(tetrahydro-2H-pyran-2-yl)-α-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8β-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione
  • (8S,10S)-10α-[[3-Amino-4-O-(tetrahydro-2H-pyran-2-yl)-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8β-hydroxyacetyl-1-methoxy-5,12-naphthacenedione
  • Pirarubicin(THP-AdriaMycin)
  • (7S,9S)-7-((2R,4S,5S,6S)-4-amino-6-methyl-5-((R)-tetrahydro-2H-pyran-2-yloxy)-tetrahydro-2H-pyran-2-yloxy)-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione
  • PIRARUBICIN
  • PIRARUBICIN HYDROCHLORIDE
  • CS-702
  • Pirarubcin
  • 1609rb
  • 4’-o-tetrahydropyranyladriamycin
  • 4’-o-tetrahydropyranyldoxorubicin
  • 5,12-naphthacenedione,10-((3-amino-2,3,6-trideoxy-4-o-(tetrahydro-2h-pyran-2-y
  • l)-alpha-l-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hy
  • Pirarubicin(BICINS)
  • (8S,10S)-10-[[3-Amino-2,3,6-trideoxy-4-O-[(2R)-tetrahydro-2H-pyran-2-yl]-α-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,12-naphthacenedione
  • Pinorubicin
  • Therarubicin
  • Pirabucin
  • 5,12-Naphthacenedione, 10-3-amino-2,3,6-trideoxy-4-O-(2R)-tetrahydro-2H-pyran-2-yl-.alpha.-L-lyxo-hexopyranosyloxy-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, (8S,10S)-
  • (8S)-10-[(2S,4S,5S,6S)-4-amino-6-methyl-5-[(2R)-oxan-2-yl]oxy-oxan-2-yl]oxy-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-9,10-dihydro-7H-tetracene-5,12-dione
  • 5,12-Naphthacenedione, 10-[[3-amino-2,3,6-trideoxy-4-O-[(2R)-tetrahydro-2H-pyran-2-yl]-α-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-, (8S,10S)-
  • Pirarubicin USP/EP/BP
  • (8S,10S)-10-(((2R,4S,5S,6S)-4-Amino-6-methyl-5-(((R)-tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione
  • Pirarubicin Topoisomerase II inhibitor ab142734
  • THP-Doxorubicin
  • Theprubicin|||THP
  • Famoxadone Impurity 14
  • Pirarubicin, Topoisomerase II inhibitor
  • Pirarubicin, 10 mM in DMSO
  • 72496-41-4
  • C32H37NO12
  • Inhibitors
  • API
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Chiral Reagents