ChemicalBook > CAS DataBase List > 2-Chloro-3-methyl-5-nitropyridine

2-Chloro-3-methyl-5-nitropyridine

Product Name
2-Chloro-3-methyl-5-nitropyridine
CAS No.
22280-56-4
Chemical Name
2-Chloro-3-methyl-5-nitropyridine
Synonyms
2-CHLORO-5-NITRO-3-PICOLINE;2-C;BUTTPARK 95\50-52;TIMTEC-BB SBB003831;2-Chloro-5-nitro-3-picoline,98%;2-CHLORO-5-NITRO-3-METHYLPYRIDINE;2-CHLORO-3-METHYL-5-NITROPYRIDINE;2-Chloro-5-nitro-3-picoline, 98% 1GR;Pyridine, 2-chloro-3-methyl-5-nitro-;2-Chloro-3-methyl-5-nitropyridine,99%
CBNumber
CB7319385
Molecular Formula
C6H5ClN2O2
Formula Weight
172.57
MOL File
22280-56-4.mol
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2-Chloro-3-methyl-5-nitropyridine Property

Melting point:
45-50 °C
Boiling point:
145 °C / 18mmHg
Density 
1.5610 (rough estimate)
refractive index 
1.5500 (estimate)
Flash point:
>110°C
storage temp. 
2-8°C
solubility 
soluble in Methanol
form 
Crystalline Powder
pka
-3.61±0.10(Predicted)
color 
Light beige to cream
Sensitive 
Hygroscopic
InChI
InChI=1S/C6H5ClN2O2/c1-4-2-5(9(10)11)3-8-6(4)7/h2-3H,1H3
InChIKey
OSIOIGXJUZTWRI-UHFFFAOYSA-N
SMILES
C1(Cl)=NC=C([N+]([O-])=O)C=C1C
CAS DataBase Reference
22280-56-4(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
36/37/38-20/21/22-41-37/38-22
Safety Statements 
37/39-26-39
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29333999
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
736961
Product name
2-Chloro-3-methyl-5-nitropyridine
Purity
97%
Packaging
1g
Price
$41.9
Updated
2023/06/20
Sigma-Aldrich
Product number
736961
Product name
2-Chloro-3-methyl-5-nitropyridine
Purity
97%
Packaging
5g
Price
$178
Updated
2023/01/07
TCI Chemical
Product number
C2020
Product name
2-Chloro-3-methyl-5-nitropyridine
Purity
>98.0%(GC)
Packaging
1g
Price
$27
Updated
2025/07/31
TCI Chemical
Product number
C2020
Product name
2-Chloro-3-methyl-5-nitropyridine
Purity
>98.0%(GC)
Packaging
5g
Price
$109
Updated
2025/07/31
Usbiological
Product number
294989
Product name
2-C-
Packaging
1g
Price
$2032
Updated
2021/12/16
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2-Chloro-3-methyl-5-nitropyridine Chemical Properties,Usage,Production

Chemical Properties

Light beige to cream colored crystalline powder

Uses

2-Chloro-3-methyl-5-nitropyridine is a nitropyridine compound, mainly used as an organic synthetic raw material or pharmaceutical intermediate.

Synthesis

21901-34-8

22280-56-4

Synthesis of compound 20: Compound 19 (3-methyl-5-nitropyridin-2(1H)-one, 16.60 g, 0.1 mol) was added to 80 mL of phosphoryl chloride (POCl3), heated to reflux and maintained for 8 hours. Upon completion of the reaction, excess phosphorus trichloride was removed by distillation. The reaction mixture was slowly poured into 300 g of crushed ice and a dark brown precipitate precipitated. The precipitate was collected by filtration to give 16.18 g of the target product 2-chloro-3-methyl-5-nitropyridine in 87.1% yield. The melting point of the product was 44.5-45.8 °C (literature value: 47-48 °C) [J.O.C., 1949, 14, 328-332].

References

[1] Journal of Medicinal Chemistry, 2009, vol. 52, # 23, p. 7653 - 7668
[2] Patent: EP2366691, 2011, A1. Location in patent: Page/Page column 10
[3] Journal of Organic Chemistry, 1949, vol. 14, p. 328,331
[4] Patent: US2010/29684, 2010, A1. Location in patent: Page/Page column 14
[5] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 5, p. 985 - 995

2-Chloro-3-methyl-5-nitropyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Chloro-3-methyl-5-nitropyridine Suppliers

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View Lastest Price from 2-Chloro-3-methyl-5-nitropyridine manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
2-Chloro-3-methyl-5-nitropyridine 22280-56-4
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2025-05-30
Shaanxi Dideu Medichem Co. Ltd
Product
2-Chloro-3-methyl-5-nitropyridine 22280-56-4
Price
US $1.00-1.00/Kg/Drum
Min. Order
1g
Purity
98%
Supply Ability
50tons
Release date
2020-05-12
Henan Fengda Chemical Co., Ltd
Product
2-Chloro-3-methyl-5-nitropyridine 22280-56-4
Price
US $5.00-0.10/KG
Min. Order
1KG
Purity
98%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-08

22280-56-4, 2-Chloro-3-methyl-5-nitropyridineRelated Search:

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  • 2-Chloro-3-methyl-5-nitropyridine,99%
  • BUTTPARK 95\50-52
  • 2-CHLORO-5-NITRO-3-METHYLPYRIDINE
  • 2-CHLORO-5-NITRO-3-PICOLINE
  • 2-CHLORO-3-METHYL-5-NITROPYRIDINE
  • 2-Chloro-3-methyl-5-nitropyridine 2-Chloro-5-nitro-3-picoline
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  • TIMTEC-BB SBB003831
  • 2-Chloro-3-methyl-5-nitropyridine ,98%
  • 2-Chloro-5-nitro-3-picoline,98%
  • 2-Chloro-5-nitro-3-picoline, 98% 1GR
  • 2-C
  • 2-Chloro-3-methyl-5-nitropyridine &gt
  • Pyridine, 2-chloro-3-methyl-5-nitro-
  • 2-Chloro-3-methyl-5-nitropyridine ISO 9001：2015 REACH
  • 22280-56-4
  • Chloropyridines
  • Halopyridines
  • Heterocycle-Pyridine series
  • Heterocyclic Building Blocks
  • Building Blocks
  • Chemical Synthesis
  • Halides
  • Pyridines
  • Chloropyridines
  • Halopyridines
  • Boronic Acid
  • Pyridine
  • Pyridines, Pyrimidines, Purines and Pteredines
  • Pyridine series
  • compounds of pyridine
  • C6