PURPUROGALLIN

Product Name: PURPUROGALLIN
CAS No.: 569-77-7
Chemical Name: PURPUROGALLIN
Synonyms: C09964;MLS0007;NSC 35676;NSC 646653;AIDS138915;CHEBI:8647;AIDS-138915;AKOS 209-004;KBio1_001351;KBio2_000828
CBNumber: CB7329636
Molecular Formula: C11H8O5
Formula Weight: 220.18
MOL File: 569-77-7.mol

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PURPUROGALLIN Property

Melting point:: 275 °C (dec.)(lit.)
Boiling point:: 321.11°C (rough estimate)
Density: 1.3824 (rough estimate)
refractive index: 1.5140 (estimate)
storage temp.: −20°C
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 6.75±0.20(Predicted)
form: Solid
color: Very Dark Brown
Merck: 7946
Stability:: Air Sensitive
LogP: 2.050 (est)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
RTECS: DE8380000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 29689
Product name: Purpurogallin
Packaging: 50mg
Price: $38
Updated: 2024/03/01

Cayman Chemical

Product number: 29689
Product name: Purpurogallin
Packaging: 100mg
Price: $67
Updated: 2024/03/01

Cayman Chemical

Product number: 29689
Product name: Purpurogallin
Packaging: 500mg
Price: $166
Updated: 2024/03/01

Cayman Chemical

Product number: 29689
Product name: Purpurogallin
Packaging: 1g
Price: $292
Updated: 2024/03/01

TRC

Product number: B416273
Product name: 2,3,4,6-Tetrahydroxy-5H-benzo[7]annulen-5-one
Packaging: 50mg
Price: $50
Updated: 2021/12/16

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PURPUROGALLIN Chemical Properties,Usage,Production

Description

Purpurogallin is a phenol that has been found in D. divisa and a derivative of pyrogallol that has diverse biological activities, including antimicrobial, antioxidant, and enzyme inhibitory properties. It is active against the Gram-positive bacteria S. aureus, methicillin-resistant S. aureus (MRSA), S. epidermidis, and B. subtilis (MICs = 11-110 μg/ml), the Gram-negative bacteria S. marcescens, P. vulgaris, K. pneumoniae, E. coli, S. typhi, and E. cloacae (MIC = 110 μg/ml for all), as well as P. falciparum strain FCB1 clone NC-1 (IC₅₀ = 55 μM). Purpurogallin (2, 5, and 10 μM) scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; ) radicals in a cell-free assay and reduces hydrogen peroxide- and radiation-induced production of reactive oxygen species (ROS) in HaCaT keratinocytes. It inhibits the activity of EGFR, glutathione-S-transferase (GST), prolyl endopeptidase, and glyoxalase I (IC₅₀s = 27.5, 8, 16, and 50 μM, respectively), as well as catechol O-methyltransferase (COMT; K_i = 0.074 μM), in cell-free assays.

Chemical Properties

BROWN FINE CRYSTALLINE POWDER

Uses

xanthine oxidase inhibitor, antioxidant

Definition

ChEBI: A cyclic ketone that is 5H-benzocycloheptene bearing an oxo group at position 5 and hydroxy groups at positions 2, 3, 4 and 6.

Enzyme inhibitor

This aglycone (FW = 220.18 g/mol) of a number of glycosides (e.g., dryophantin) from several nutgalls. Purpurogallin is a scavenger of polymorphonuclear leukocyte-derived oxyradicals and acts as a cardioprotector. Target(s): catechol O-methyltransferase; cystathionine b-synthase; glutathione-disulfide reductase; glutathione S-transferase; HIV-1 integrase; lactoylglutathione lyase, or glyoxalase I; 3-phosphoglycerate kinase; prolyl endopeptidase; protein-tyrosine kinase; and xanthine oxidase.

PURPUROGALLIN Preparation Products And Raw materials

Raw materials

Preparation Products

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PURPUROGALLIN Suppliers

China 30 Germany 2 Switzerland 1 United Kingdom 6 United States 13 Global 52

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569-77-7, PURPUROGALLINRelated Search:

2,4-Dihydroxyacetophenone 4-Allylpyrocatechol Protocatechualdehyde 4-Ethylresorcinol 2,3,4-Trihydroxybenzaldehyde 2,3-Dihydroxybenzaldehyde 5-METHYLPYROGALLOL 2,3-dimethylphenol Pyrogallol 2',3',4'-TRIHYDROXYACETOPHENONE Hydroxytyrosol 2-METHYLPHENETHYL ALCOHOL 4-ALLYLPHENOL PURPUROGALLIN 2',3'-DIHYDROXYACETOPHENONE 4-Hydroxystyrene 2-HYDROXYACETOPHENONE 2'-Hydroxyacetophenone

2,3,4,6-tetrahydroxy-5h-benzocycloheptene-5-on

2,3,4,6-tetrahydroxy-5h-benzocycloheptene-5-one

2,3,4,6-TETRAHYDROXY-BENZOCYCLOHEPTEN-5-ONE

AKOS 209-004

PURPUROGALLIN

PURPUROGALLIN(RG)

PURPUROGALLINE

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NSC 35676

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1,2,3,9-tetrahydroxy-8-benzo[7]annulenone

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2,3,4,6-Tetrahydroxy-5H-benzo[a]cyclohepten-5-one

PURPUROGALLIN, TECH.

AIDS138915

2,3,4,5-tetrahydroxy-6-benzo[7]annulenone

AIDS-138915

C09964

CHEBI:8647

DivK1c_006407

KBio1_001351

KBio2_000828

KBio2_003396

KBio2_005964

KBio3_001663

KBioSS_000828

MLS0007

NCGC00095229-01

NCGC00095229-02

Oprea1_685478

SDCCGMLS-0066536.P001

SPBio_000424

Spectrum_000348

Spectrum2_000582

SPECTRUM210505

Spectrum4_001547

5H-Benzocyclohepten-5-one, 2,3,4,6-tetrahydroxy-

Inhibitor,inhibit,Purpurogallin,Xanthine Oxidase

569-77-7

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