ChemicalBook > CAS DataBase List > Ginsenoside Rg1

Ginsenoside Rg1

Product Name: Ginsenoside Rg1
CAS No.: 22427-39-0
Chemical Name: Ginsenoside Rg1
Synonyms: Rg1;SANCHINOSIDE C1;PANAXOSIDE A;ginsenosidea2;ginsenosideg1;panaxosiderg1;Gensenoside Rg1;GINSENOSIDE RGL;GINSENOSIDE RG1;Panaxsaponin Rg1
CBNumber: CB7331840
Molecular Formula: C42H72O14
Formula Weight: 801.01
MOL File: 22427-39-0.mol

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Ginsenoside Rg1 Property

Melting point:: 194～197℃
Boiling point:: 898.5±65.0 °C(Predicted)
Density: 1.33±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: DMSO (Slightly), Methanol (Slightly), Pyridine (Slightly)
pka: 12.91±0.70(Predicted)
form: Solid
color: White to Off-White
biological source: Panax notoginseng (Burk.) F.H.Chen
Stability:: Hygroscopic
InChIKey: YURJSTAIMNSZAE-OLCOBRLXNA-N
LogP: 1.670 (est)
CAS DataBase Reference: 22427-39-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,T,F
Risk Statements: 22-39/23/24/25-23/24/25-11
Safety Statements: 2-45-36/37-16-7-24/25
WGK Germany: 3
RTECS: LY9537200
HS Code: 29389090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR2200
Product name: Ginsenoside Rg1
Purity: certified reference material, pharmaceutical secondary standard
Packaging: 50MG
Price: $240
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1291672
Product name: Ginsenoside Rg1
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 20mg
Price: $335
Updated: 2025/07/31

Sigma-Aldrich

Product number: 00370580
Product name: Ginsenoside Rg1
Purity: primary pharmaceutical reference standard
Packaging: 10mg
Price: $783
Updated: 2025/07/31

TCI Chemical

Product number: G0533
Product name: Ginsenoside Rg1
Packaging: 25MG
Price: $103
Updated: 2025/07/31

TCI Chemical

Product number: G0533
Product name: Ginsenoside Rg1
Packaging: 100MG
Price: $258
Updated: 2025/07/31

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Ginsenoside Rg1 Chemical Properties,Usage,Production

Description

Ginsenoside RG1(Rg1) is a natural product found in Panax notoginseng, Panax ginseng, and Panax vietnamensis. It is one of the primary bioactive ingredients in Panax notoginseng saponins. Numerous studies have indicated that Rg1 plays significant roles in health benefits such as anticancer, neuroprotective, anti-senescence, anti-inflammation, and antioxidative effects. Also, extensive research has demonstrated that Rg1 is associated with various diseases, including cardiovascular disease, Alzheimer’s disease, spinal cord injury, and liver injury. Xue et al. and Yu et al. demonstrated that Rg1 ameliorated streptozotocin-induced oxidative stress and myocardial apoptosis and suppressed HG-induced mesenchymal activation and fibrosis[1].

Chemical Properties

White solid

Uses

Ginsenoside Rg1 protects against arthitis through osteoclast differentiation inhibition. Anti-tumor agent, inhibits the NF-kB-dependant MMP-expression in PMA (phorbol myristate acetate)-induced tumor cell invasion.

Definition

ChEBI: A ginsenoside found in Panax ginseng and Panax japonicus var. major that is dammarane which is substituted by hydroxy groups at the 3beta, 6alpha, 12beta and 20 <ital pro-S positions, in which the hydroxy groups at positions 6 and 20 have been converted to the corresponding beta-D-glucopyranosides, and in which a double bond has been introduced at the 24-25 posit on.

in vivo

In the inflamed joints of adjuvant-induced arthritis (AIA) rats, the level of p-IκBα and p-p65 is significantly higher than in controls and PPAR-γ levels are significantly lower. Treatment with Ginsenoside Rg1 in vivo inhibits IκBα phosphorylation, reduces NF-κB nuclear translocation and upregulates PPAR-γ expression^[2]. Ginsenoside Rg1 (G-Rg1) and Ginsenoside Rg2 (G-Rg2) reduce the escape latencies on the last two training days compared to the Alzheimer's disease (AD) model group (p<0.05). In the spatial exploration test, the total time spent in the target quadrant and the number of mice that exactly crossed the previous position of the platform are clearly shorter and lower, respectively, in the AD model group mice than in the normal control group mice (p<0.01), a trend that is reversed by treatment with Ginsenoside Rg1 and Ginsenoside Rg2 (Ginsenoside Rg1, p<0.01; Ginsenoside Rg2, p<0.05). Treatment with Ginsenoside Rg1 and Ginsenoside Rg2 effectively improve cognitive function of the mice that have declined due to AD. Ginsenoside Rg1 and Ginsenoside Rg2 reduce Aβ_1-42 accumulation in APP/PS1 mice. In the Ginsenoside Rg1 and Ginsenoside Rg2 treated mice, the pathological abnormalities observed in the APP/PS1 mice are gradually ameliorated. Clear nucleoli and light brown, sparsely scattered Aβ deposits are visible^[1].

IC 50

Aβ_1-42; p65

References

[1] Hui Liu. “Ginsenoside Rg1 attenuates the inflammation and oxidative stress induced by diabetic nephropathy through regulating the PI3K/AKT/FOXO3 pathway.” Annals of translational medicine 9 24 (2021): 1789.

Ginsenoside Rg1 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Ginsenoside Rg1 manufacturers

Lianyungang Kaiyu Environmental Tech Co., Ltd.

Product: Ginsenoside Rg1 22427-39-0
Price: US $1200.00-1100.00/ton
Min. Order: 1ton
Purity: 99%
Supply Ability: 1000T/M
Release date: 2025-10-13

Shaanxi Xianhe Biotech Co., Ltd

Product: GINSENOSIDE Rg1 22427-39-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 1000kg
Release date: 2025-04-29

Shaanxi Cuikang Pharmaceutical Technology Co., Ltd

Product: Ginsenoside Rg1 22427-39-0
Price: US $0.00/g
Min. Order: 1g
Purity: 50%-98% HPLC
Supply Ability: 100kg
Release date: 2024-03-14

22427-39-0, Ginsenoside Rg1Related Search:

Ginsenoside Rd GINSENOSIDE RE (20S)-Ginsenoside Rg2,GINSENOSIDE RG2 Ginseng extract Ginsenoside Rb1 Ginsenoside Rh2 GinsenosideRo TRIBULOSIDE Ginsenoside Re GINSENOSIDE F2 Panaxadiol Panaxatriol Ginsenoside-Rg5 Ginsenoside Rh1 GINSENOSIDEF1 Ginsenoside Rb3 Ginsenoside Rk3 GINSENOSIDE RB2

(3b,6a,12b)-3,12-dihydroxydammar-24-ene-6,20- diylbis(beta-d-glucopyranoside)

(3beta,6alpha,12beta)-3,12-dihydroxydammar-24-ene-6,20-diylbis[beta-D-glucopyranoside]

Ginsenoside Rg1 std.

Ginsenoside Rg1 (CAS# 22427-39-0)

Gensenoside Rg1

GINSENOSIDE RG1 WITH HPLC

GINSENOSIDE-RG1 (GINSENOSIDE A2: GINSENOSIDE G1)

dihydroxydammar-24-ene-6,20-diylbis-

β-D-Glucopyranoside, (3β,6α,12β)-3,12-

(3β,6α,12β)-3,12-Dihydroxydammar-24-ene-6,20-diyl bis-β-D-glucopyranoside

[3β,12β-Dihydroxy-5α-dammar-24-ene-6α,20-diyl]bis(β-D-glucopyranoside)

20-(β-D-Glucopyranosyloxy)-3β,12β-dihydroxy-5α-dammara-24-ene-6α-yl β-D-glucopyranoside

3β,12β-Dihydroxy-5α-dammar-24-ene-6α,20-diylbis(β-D-glucopyranoside)

Ginsenoside Rg1 ,98%

Ginsenoside Rg1(Sanchinoside C1)

Rg1

Ginsenoside Rg1 (saponin of Panax ginseng)

(6)-beta-d-glucopyranosyl-(20)-beta-d-glucopyranosyl-20s-protopanaxatriol

ginsenosidea2

ginsenosideg1

panaxosiderg1

DaMMarane, β-D-glucopyranoside deriv.

Panaxoside A(7CI)

Panaxsaponin Rg1

PANAXOSIDE A

SANCHINOSIDE C1

SANCHINOSIDE C1,PANAXOSIDE A

GINSENOSIDE RGL

GINSENOSIDE RG1

Ginsenoside Rg1, >=99%

Ginsenoside Rg1, 98%, from Panax ginseng C. A. Mey.

Ginsenoside Rg1 22427-39-0

Ginsenoside Rg1 RS

Ginsenoside Rg1 Standard

β-D-Glucopyranoside, (3β,6α,12β)-3,12-dihydroxydammar-24-ene-6,20-diyl bis-

(2R,3R,4S,5S,6R)-2-(((3S,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-dihydroxy-4,4,8,10,14-pentamethyl-17-((S)-6-methyl-2-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hept-5-en-2-yl)hexadecahydro-1H-cyclopenta[a]phenanthren-6-y

20-(beta-D-Glucopyranosyloxy)-3beta,12beta-dihydroxydammar-24-en-6alpha-yl beta-D-Glucopyranoside

Ginsenoside Rg1 (10mM in DMSO)

(2R,3R,4S,5S,6R)-2-[[(3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-dihydroxy-4,4,8,10,14-pentamethyl-17-[(2S)-6-methyl-2-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhept-5-en-2-yl]-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-6-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol

Ginsenoside Rg1 (8CI)

Ginsenoside Rg1 reference substance

Ginsenoside Rg1(P) (AHP Verified)

Ginsenoside Rg1, natural triterpenoid saponin

Multi-Component Ginsenoside Calibration Solution.

22427-39-0

11021-41-0

Inhibitors

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

Ginsenoside series

The group of Ginsenosides

Saponins