ChemicalBook > CAS DataBase List > t-Boc-N-Amido-PEG2-Propargyl

t-Boc-N-Amido-PEG2-Propargyl

Product Name
t-Boc-N-Amido-PEG2-Propargyl
CAS No.
869310-84-9
Chemical Name
t-Boc-N-Amido-PEG2-Propargyl
Synonyms
Propargyl-PEG2-NHBoc;Propargyl-PEG3-Boc Amine;t-Boc-N-Amido-PEG2-Propargyl;N-Boc-2-[2-(2-propyn-1-yloxy)ethoxy]ethanamine;tert-butyl N-[2-(2-prop-2-ynoxyethoxy)ethyl]carbamate;tert-butyl (2-(2-(prop-2-yn-1-yloxy)ethoxy)ethyl)carbamate;Carbamic acid, N-[2-[2-(2-propyn-1-yloxy)ethoxy]ethyl]-, 1,1-dimethylethyl ester
CBNumber
CB73364012
Molecular Formula
C12H21NO4
Formula Weight
243.3
MOL File
869310-84-9.mol
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t-Boc-N-Amido-PEG2-Propargyl Property

Boiling point:
344.2±27.0 °C(Predicted)
Density 
1.033±0.06 g/cm3(Predicted)
storage temp. 
Storage temp. 2-8°C
form 
Liquid
pka
12.22±0.46(Predicted)
color 
Colorless to light yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P330Rinse mouth.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Activate Scientific
Product number
AS103478
Product name
Propargyl-PEG2-NHBoc
Purity
95+%
Packaging
1g
Price
$404
Updated
2021/12/16
Activate Scientific
Product number
AS103478
Product name
Propargyl-PEG2-NHBoc
Purity
95+%
Packaging
5G
Price
$1116
Updated
2021/12/16
Absolute Chiral
Product number
P1048-00-N
Product name
tert-butyl(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethyl)carbamate
Purity
95%
Packaging
100mg
Price
$168
Updated
2021/12/16
Acrotein
Product number
AC-3596
Product name
Propargyl-PEG2-NHBoc
Purity
97%
Packaging
0.5g
Price
$183.34
Updated
2021/12/16
Absolute Chiral
Product number
P1048-00-N
Product name
tert-butyl(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethyl)carbamate
Purity
95%
Packaging
250mg
Price
$368
Updated
2021/12/16
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t-Boc-N-Amido-PEG2-Propargyl Chemical Properties,Usage,Production

Description

t-Boc-N-Amido-PEG2-propargyl is crosslinker consisting of a propargyl group and a t-Boc protected amine group. The propargyl group reacts with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry reactions. The t-Boc protected amine can be deprotected under mild acidic conditions.

Uses

Propargyl-PEG2-NHBoc is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-NHBoc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Propargyl-PEG2-NHBoc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC 50

Cleavable Linker; PEGs; Alkyl/ether

References

[1] Nello Mainolfi, et al. rak degraders and uses thereof. US20190192668A1.

t-Boc-N-Amido-PEG2-Propargyl Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from t-Boc-N-Amido-PEG2-Propargyl manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
Propargyl-PEG2-NHBoc 869310-84-9
Price
US $0.00/g
Min. Order
5g
Purity
>98.00%
Supply Ability
5g
Release date
2024-03-26

869310-84-9, t-Boc-N-Amido-PEG2-PropargylRelated Search:

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  • tert-butyl (2-(2-(prop-2-yn-1-yloxy)ethoxy)ethyl)carbamate
  • t-Boc-N-Amido-PEG2-Propargyl
  • Propargyl-PEG2-NHBoc
  • N-Boc-2-[2-(2-propyn-1-yloxy)ethoxy]ethanamine
  • Propargyl-PEG3-Boc Amine
  • tert-butyl N-[2-(2-prop-2-ynoxyethoxy)ethyl]carbamate
  • Carbamic acid, N-[2-[2-(2-propyn-1-yloxy)ethoxy]ethyl]-, 1,1-dimethylethyl ester
  • 869310-84-9