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Moringin

Product Name: Moringin
CAS No.: 73255-40-0
Chemical Name: Moringin
Synonyms: Moringin;Moringa seed;Moringin, 10 mM in DMSO;α-L-Mannopyranoside, 4-(isothiocyanatomethyl)phenyl 6-deoxy-;(2S,3R,4R,5R,6S)-2-(4-(Isothiocyanatomethyl)phenoxy)-6-methyltetrahydro-2H-pyran-3,4,5-triol
CBNumber: CB73372657
Molecular Formula: C14H17NO5S
Formula Weight: 311.35
MOL File: 73255-40-0.mol

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Moringin Property

Boiling point:: 523.7±50.0 °C(Predicted)
Density: 1.42±0.1 g/cm3(Predicted)
pka: 12.95±0.70(Predicted)
form: Solid
color: White to light yellow
InChI: InChI=1/C14H17NO5S/c1-8-11(16)12(17)13(18)14(19-8)20-10-4-2-9(3-5-10)6-15-7-21/h2-5,8,11-14,16-18H,6H2,1H3/t8-,11-,12+,13+,14-/s3
InChIKey: QAZIHHJTZPNRCM-TZRLYUMSNA-N
SMILES: O(C1C=CC(CN=C=S)=CC=1)[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O |&1:11,13,15,17,19,r|

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Hazard and Precautionary Statements (GHS)

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Moringin Chemical Properties,Usage,Production

Uses

Moringin is a potent and selective TRPA1 ion channel natural agonist with an EC50 of 3.14 μM. Moringin does not activate or activates very weakly the vanilloids somatosensory channels TRPV1, TRPV2, TRPV3 and TRPV4, and the melastatin cooling receptor TRPM8. Moringin has hypoglycemic, antimicrobial, anti-inflammatory, anticancer and neuroprotection activities[1][2].

in vivo

In experimental autoimmune encephalomyelitis (EAE) mice, Moringin (10 mg/kg; intraperitoneally daily for 5 week) pretreatment normalizes the aberrant Wnt-β-catenin pathway, resulting in GSK3β inhibition and β-catenin upregulation, which regulates T-cell activation (CD4 and FoxP3), suppresses the main inflammatory mediators (IL-1β, IL-6, and COX2), through activation of PPARγ. Moringin increases antioxidant Nrf2 expression in EAE mice^[3].

References

[1] Gigliola Borgonovo, et al. Moringin, A Stable Isothiocyanate from Moringa oleifera, Activates the Somatosensory and Pain Receptor TRPA1 Channel In Vitro. Molecules. 2020 Feb 22;25(4):976. DOI:10.3390/molecules25040976
[2] Santa Cirmi, et al. Moringin from Moringa Oleifera Seeds Inhibits Growth, Arrests Cell-Cycle, and Induces Apoptosis of SH-SY5Y Human Neuroblastoma Cells through the Modulation of NF-κB and Apoptotic Related Factors. Int J Mol Sci. 2019 Apr 19;20(8):1930. DOI:10.3390/ijms20081930
[3] Sabrina Giacoppo, et al. Moringin activates Wnt canonical pathway by inhibiting GSK3β in a mouse model of experimental autoimmune encephalomyelitis. Drug Des Devel Ther. 2016 Oct 4;10:3291-3304. DOI:10.2147/DDDT.S110514

Moringin Preparation Products And Raw materials

Raw materials

Preparation Products

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Moringin

α-L-Mannopyranoside, 4-(isothiocyanatomethyl)phenyl 6-deoxy-

Moringa seed

(2S,3R,4R,5R,6S)-2-(4-(Isothiocyanatomethyl)phenoxy)-6-methyltetrahydro-2H-pyran-3,4,5-triol

Moringin, 10 mM in DMSO

73255-40-0