ChemicalBook > CAS DataBase List > 5-BROMO-2-(METHYLAMINO)PYRIMIDINE

5-BROMO-2-(METHYLAMINO)PYRIMIDINE

Product Name
5-BROMO-2-(METHYLAMINO)PYRIMIDINE
CAS No.
31402-54-7
Chemical Name
5-BROMO-2-(METHYLAMINO)PYRIMIDINE
Synonyms
5-BROMO-2-(METHYLAMINO);5-Bromo-2-(methylamino)pyridine;5-BROMO-2-(METHYLAMINO)PYRIMIDINE;5-Bromo-N-methyl-2-pyrimidinamine;5-bromo-N-methylpyrimidin-2-amine;2-(Methylamino)-5-bromopyrimidine;(5-BROMOPYRIMIDIN-2-YL)METHYLAMINE;2-Pyrimidinamine, 5-bromo-N-methyl-;Pyrimidine, 5-bromo-2-(methylamino)-;N-(5-Bromopyrimidin-2-yl)-N-methylamine
CBNumber
CB7342527
Molecular Formula
C5H6BrN3
Formula Weight
188.03
MOL File
31402-54-7.mol
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5-BROMO-2-(METHYLAMINO)PYRIMIDINE Property

Melting point:
171-173℃
Boiling point:
283.5±32.0 °C(Predicted)
Density 
1.686±0.06 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
pka
2.07±0.10(Predicted)
Appearance
White to off-white Solid
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Safety

Hazard Codes 
Xi
Hazard Note 
Irritant
HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
B696950
Product name
5-Bromo-2-(methylamino)pyrimidine
Packaging
100mg
Price
$45
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
B1746
Product name
5-Bromo-2-(methylamino)pyrimidine
Purity
98%
Packaging
1g
Price
$10
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
B1746
Product name
5-Bromo-2-(methylamino)pyrimidine
Purity
98%
Packaging
5g
Price
$30
Updated
2021/12/16
SynQuest Laboratories
Product number
3H31-9-W0
Product name
5-Bromo-2-(methylamino)pyrimidine
Packaging
1g
Price
$45
Updated
2021/12/16
Matrix Scientific
Product number
118854
Product name
5-Bromo-N-methylpyrimidin-2-amine
Purity
95+%
Packaging
1g
Price
$46
Updated
2021/12/16
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5-BROMO-2-(METHYLAMINO)PYRIMIDINE Chemical Properties,Usage,Production

Synthesis

32779-36-5

74-89-5

31402-54-7

1. 5-Bromo-2-chloropyrimidine (3 g, 15.5 mmol), 40% aqueous methylamine (35 ml) and methanol (20 ml) were added to a reaction flask and mixed well with stirring. 2. The reaction mixture was heated to reflux and kept at that temperature for 3 days. 3. After completion of the reaction, the reaction was cooled to room temperature. 4. The solvent was removed by evaporation using a rotary evaporator under reduced pressure. 5. The residue was extracted by partitioning with dichloromethane and 1M sodium hydroxide. 6. The residue was extracted by partitioning with dichloromethane and 1 M sodium hydroxide solution. 6. The organic layer was separated and dried over anhydrous magnesium sulfate. 7. After filtration to remove the desiccant, the solvent was again evaporated under reduced pressure using a rotary evaporator to give the white solid product 5-bromo-2-methylaminopyrimidine (3.0 g, 100% yield). 8. The product was characterized by 1H-NMR (CDCl3): δ 2.98 (3H, d, J=5.12 Hz), 5.16 (1H, brs), 8.29 (2H, s).

References

[1] Patent: US2010/130492, 2010, A1. Location in patent: Page/Page column 93
[2] Patent: WO2010/12747, 2010, A1. Location in patent: Page/Page column 16-17
[3] Patent: WO2007/84786, 2007, A1. Location in patent: Page/Page column 90
[4] ACS Medicinal Chemistry Letters, 2011, vol. 2, # 1, p. 34 - 38
[5] Patent: WO2012/109423, 2012, A1. Location in patent: Page/Page column 18

5-BROMO-2-(METHYLAMINO)PYRIMIDINE Preparation Products And Raw materials

Raw materials

acetonitrile Ethanol Sodium sulfate Methylamine 5-Bromo-2-chloropyrimidine 2-Aminopyrimidine Ethyl acetate Sodium bicarbonate Bromine Dichloromethane PETROLEUM ETHER Iodomethane

Preparation Products

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View Lastest Price from 5-BROMO-2-(METHYLAMINO)PYRIMIDINE manufacturers

Dideu Industries Group Limited
Product
5-BROMO-2-(METHYLAMINO)PYRIMIDINE 31402-54-7
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-12-13
Career Henan Chemical Co
Product
5-BROMO-2-(METHYLAMINO)PYRIMIDINE 31402-54-7
Price
US $2.00/KG
Min. Order
1g
Purity
98%min
Supply Ability
ask
Release date
2020-01-08

31402-54-7, 5-BROMO-2-(METHYLAMINO)PYRIMIDINERelated Search:

5-BROMO-2-MORPHOLIN-1-YL-PYRIMIDINE 5-BROMO-2-(PYRROLIDIN-1-YL)PYRIMIDINE N-(4,6-DIMETHYLPYRIMIDIN-2-YL)BENZENE-1,4-DIAMINE 1-(5-BROMOPYRIMIDIN-2-YL)PIPERIDINE-4-CARBOXYLIC ACID 1-(5-Bromopyrimidin-2-yl)piperidine-3-carboxylic acid 1-(5-BROMOPYRIMIDIN-2-YL)[1,4]DIAZEPANE 5-BROMO-2-(ISOPROPYLAMINO)PYRIMIDINE 5-Bromopyrimidine 2-(Methylamino)pyridine 2-[4-(5-BROMOPYRIMIDIN-2-YL)PIPERAZIN-1-YL]ETHANOL 5-Bromo-2-(piperidin-1-yl)pyrimidine 5-BROMO-N-BUTYL-2-PYRIMIDINAMINE BENZYL-(5-BROMO-PYRIMIDIN-2-YL)-AMINE METHYL {[2-(ACETYLAMINO)-5-BROMO-6-METHYLPYRIMIDIN-4-YL]THIO}ACETATE N-(5-BROMO-4-METHOXY-6-METHYLPYRIMIDIN-2-YL)ACETAMIDE N-(5-BROMO-2-PYRIMIDINYL)-4-METHOXYBENZENECARBOXAMIDE N-(5-BROMO-4,6-DIMETHYLPYRIMIDIN-2-YL)-2-THIENYLFORMAMIDE N-ALLYL-N-(5-BROMO-4-METHOXY-6-METHYLPYRIMIDIN-2-YL)ACETAMIDE

  • 5-BROMO-2-(METHYLAMINO)PYRIMIDINE
  • (5-BROMOPYRIMIDIN-2-YL)METHYLAMINE
  • 5-Bromo-2-(methylamino)pyridine
  • (5-BROMOPYRIMIDIN-2-YL)METHYLAMINE, 95+%
  • 2-(Methylamino)-5-bromopyrimidine
  • 5-bromo-N-methylpyrimidin-2-amine
  • N-(5-Bromopyrimidin-2-yl)-N-methylamine
  • REF DUPL: N-(5-Bromopyrimidin-2-yl)-N-methylamine
  • 2-Pyrimidinamine, 5-bromo-N-methyl-
  • 5-Bromo-N-methyl-2-pyrimidinamine
  • 5-BROMO-2-(METHYLAMINO)
  • Pyrimidine, 5-bromo-2-(methylamino)-
  • 5-BROMO-2-(METHYLAMINO)PYRIMIDINE ISO 9001：2015 REACH
  • 31402-54-7
  • Organohalides
  • Pyrimidine