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Tyramine hydrochloride

Product Name
Tyramine hydrochloride
CAS No.
60-19-5
Chemical Name
Tyramine hydrochloride
Synonyms
Mydrial;Uteramin;Tyramine HCI;TyraMine hydro;TRYPTAMINE HCL;Hydrphenacetamine;TIMTEC-BB SBB000359;tyraminemonochloride;yramine hydrochloride;Tyramine hydrochloride
CBNumber
CB7345058
Molecular Formula
C8H12ClNO
Formula Weight
173.64
MOL File
60-19-5.mol
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Tyramine hydrochloride Property

Melting point:
253-255 °C(lit.)
Boiling point:
269°C/760mmHg
storage temp. 
Store below +30°C.
solubility 
H2O: soluble50 mg/ml, clear, colorless to faintly yellow
form 
Crystalline Powder
color 
White to almost white
PH
<7 (H2O)
Sensitive 
Hygroscopic
Merck 
14,9835
BRN 
3627058
Stability:
Hygroscopic
LogP
0.722 (est)
CAS DataBase Reference
60-19-5(CAS DataBase Reference)
EPA Substance Registry System
Phenol, 4-(2-aminoethyl)-, hydrochloride (60-19-5)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
22-24/25-36-26
WGK Germany 
3
RTECS 
NL4375000
F 
3-8-10
TSCA 
Yes
HS Code 
29222900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T2879
Product name
Tyramine hydrochloride
Purity
≥98%
Packaging
1g
Price
$61.3
Updated
2024/03/01
Sigma-Aldrich
Product number
8.18444
Product name
2-(4-Hydroxyphenyl)ethylammonium chloride
Purity
for synthesis
Packaging
25G
Price
$94.8
Updated
2024/03/01
TCI Chemical
Product number
A0303
Product name
Tyramine Hydrochloride
Purity
>98.0%(T)
Packaging
1g
Price
$20
Updated
2024/03/01
TCI Chemical
Product number
A0303
Product name
Tyramine Hydrochloride
Purity
>98.0%(T)
Packaging
25g
Price
$78
Updated
2024/03/01
Alfa Aesar
Product number
A12220
Product name
Tyramine hydrochloride, 98%
Packaging
5g
Price
$26.65
Updated
2024/03/01
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Tyramine hydrochloride Chemical Properties,Usage,Production

Chemical Properties

Off-White to Light Yellow Powder

Occurrence

Tyramine was originally a compound isolated from ergot alkaloids and decaying animal tissue. It has pharmacological effects such as increasing blood pressure and exciting the uterus.

Uses

Tyramine hydrochloride occurs naturally in the body, and it's found in certain foods. It is an amino acid that helps regulate blood pressure. Tyramine hydrochloride is a sympathomimetic, the hydrochloride salt of the naturally-occurring monoamine derived from the amino acid tyrosine. Tyramine acts as a catecholamine releasing agent but cannot cross the blood-brain barrier.

Application

Tyramine hydrochloride (T-HCl) is a kind of fluorogenic substrate of peroxidase. It is a naturally occurring monoamine derived from tyrosine. Tyramine Hydrochloride has been used:
coinfused with adenosine in control subjects and patients in order to reduce leg blood flow by 50% without affecting arterial blood pressure.
labelled with fluorescence dyes (Atto 488 and Atto 655) to serve as a substrate for peroxidase in immunofluorescence analysis.
used in dimethylformamide, labelled with 5-(and-6)carboxyfluorescein, succinimidyl ester/biotin to serve as a substrate for peroxidase in tyramide signal amplification.
Neurotransmitter.

Hazard

Tyramine hydrochloride can cause eye irritation and damage in some persons.It also can cause inflammation of the skin oncontact in some persons.Long-term exposure to respiratory irritants may result in disease of the airways involving difficult breathing and related systemic problems.Long term exposure to high dust concentrations may cause changes in lung function i.e. pneumoconiosis.

Biochem/physiol Actions

Tyramine hydrochloride is a biogenic amine and a neuromodulator localized to the nervous system. Tyrosine decarboxylase catalysis the formation of tyramine from tyrosine. Tyramine is found to be associated with a number of psychiatric disorders. Tyramine ingestion depletes serotonin, epinephrine and norepinephrine reserves. This results in elevated biological events such as cardiovascular function, blood pressure, glucose production and overall metabolism. It also causes depression, migraine and insomnia. Tyramine is present is several food sources. The process of food fermentation and spoilage increases its tyramine content.

Synthesis

Tyramine [2-(p-hydroxyphenyl) ethylamine], a significant metabolite of tyrosine, enzymatic synthesis of tyramine was established by two-step biocatalytic reaction. Firstly, l-tyrosine was prepared from raw pyruvate fermentation broth under the catalysis of TPL. Pyruvate fermentation broth was simply centrifuged, and then the supernatant was diluted and used as substrate to produce l-tyrosine. Secondly, l-tyrosine was collected as starting material to synthesize tyramine by immobilized TDC cells from Lactobacillus brevis. Pyridoxal phosphate was the common coenzyme for these two enzymes.

Purification Methods

Crystallise the hydrochloride from EtOH by addition of diethyl ether, or from conc HCl. [Beilstein 3 II 355.]

Tyramine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Tyramine hydrochloride Suppliers

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View Lastest Price from Tyramine hydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Tyramine hydrochloride 60-19-5
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
99%min
Supply Ability
1000kg
Release date
2021-11-30
Hebei Weibang Biotechnology Co., Ltd
Product
Tyramine hydrochloride 60-19-5
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-22
Hebei Yanxi Chemical Co., Ltd.
Product
Tyramine Hydrochloride 60-19-5
Price
US $0.00/kg
Min. Order
1kg
Purity
99.0%~100.5%
Supply Ability
20tons
Release date
2023-09-14

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