ChemicalBook > CAS DataBase List > DL-Serine

DL-Serine

Product Name: DL-Serine
CAS No.: 302-84-1
Chemical Name: DL-Serine
Synonyms: SERINE;serin;DL-SER;DL-Serin;DL-Ser-OH;DL-SERINE;Serine, dl-;H-DL-SER-OH;DL-SERINE,FCC;DL-Serine >
CBNumber: CB7345179
Molecular Formula: C3H7NO3
Formula Weight: 105.09
MOL File: 302-84-1.mol

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DL-Serine Property

Melting point:: 240 °C (dec.) (lit.)
Boiling point:: 197.09°C (rough estimate)
Density: 1.53
refractive index: 1.4368 (estimate)
storage temp.: Store below +30°C.
solubility: H2O: soluble
form: Crystalline Powder
pka: 2.19(at 25℃)
color: White
Odor: Odorless
Water Solubility: 50.23 g/L (25 ºC)
Merck: 14,8460
BRN: 1721402
LogP: -3.460
CAS DataBase Reference: 302-84-1(CAS DataBase Reference)
NIST Chemistry Reference: DL-Serine(302-84-1)
EPA Substance Registry System: Serine (302-84-1)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 24/25-36-26
WGK Germany: 3
RTECS: VT8100000
TSCA: Yes
HS Code: 29225000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S4375
Product name: DL-Serine
Purity: ≥98% (TLC)
Packaging: 1kg
Price: $725
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.41235
Product name: DL-Serine
Purity: for synthesis
Packaging: 100g
Price: $92.7
Updated: 2025/07/31

Sigma-Aldrich

Product number: 68353
Product name: DL-Serine
Purity: analytical standard
Packaging: 100mg
Price: $51.8
Updated: 2022/05/15

TCI Chemical

Product number: S0034
Product name: DL-Serine
Purity: >98.0%(T)
Packaging: 25g
Price: $21
Updated: 2025/07/31

TCI Chemical

Product number: S0034
Product name: DL-Serine
Purity: >98.0%(T)
Packaging: 500g
Price: $143
Updated: 2025/07/31

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DL-Serine Chemical Properties,Usage,Production

Description

DL-Serine is a kind of neutral aliphatic amino acids containing hydroxyl groups with polarity but being uncharged, and belongs to nonessential amino acids for human body. It has a high content in sericin silk protein and fibroin protein. It can be formed from the methyl transfer reaction of glycine. It can also be converted to pyruvate or hydroxy pyruvate through deamination. It is also an important raw material for in vivo synthesis of choline and cysteine.

Chemical Properties

DL-Serine is a kind of colorless monoclinic columnar or lamellae crystal. It is soluble in water (at 20℃, the water solubility is 380g/L), insoluble in ether and ethanol; Decomposition point: 246℃.

Uses

DL-Serine is used in the synthesis of novel tryptoline derivatives as IDO (indoleamine 2,3-Deoxygenase) inhibitors, for potential use in Alzheimer’s treatment.

Preparation

DL-serine is obtained by complexing glycine under the catalysis of copper ions and then combining with formaldehyde under alkaline conditions, followed by acidification, ion exchange, and crystallization in ethanol.?

Definition

ChEBI: Serine is an alpha-amino acid that is alanine substituted at position 3 by a hydroxy group. It has a role as a fundamental metabolite. It is an alpha-amino acid and a polar amino acid. It contains a hydroxymethyl group. It is a conjugate base of a serinium. It is a conjugate acid of a serinate. It is a tautomer of a serine zwitterion.

Application

Serine is a non-essential amino acid and a natural ligand and allosteric activator of pyruvate kinase M2. Serine helps retain the skin's moisture balance.

Synthesis Reference(s)

Canadian Journal of Chemistry, 33, p. 1119, 1955 DOI: 10.1139/v55-131
The Journal of Organic Chemistry, 35, p. 1505, 1970 DOI: 10.1021/jo00830a054

Biochem/physiol Actions

NMDA agonist acting at the glycine site; precursor of glycine by serine hydroxymethyltransferase

Safety Profile

When heated to decomposition emits toxic fumes of NOx.

in vitro

DL-Serine, a fundamental metabolite, is a mixture of D-Serine and L-Serine. DL-Serine has antiviral activity against the multiplication of tobacco mosaic virus (TMV).
Subcutaneous injection of DL-serine increases the number and size of renal tubular cell tumors in male W rats treated with 500 or 1,000 ppm N-ethyl-N-hydroxyethylnitrosamine.

DL-Serine Preparation Products And Raw materials

Raw materials

Glycine

Preparation Products

D-Serine DL-GLYCERIC ACID MORPHOLINE-3,4-DICARBOXYLIC ACID 4-TERT-BUTYL ESTER Glycine L-Serine DL-Tryptophan L-Cystine Leuprorelin

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View Lastest Price from DL-Serine manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: DL-Serine 302-84-1
Price: US $1.00-4.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200000KG
Release date: 2025-09-12

Anhuyan (Hainan) Biotechnology Co., LTD

Product: DL-Serine 302-84-1
Price: US $1.00/kg
Min. Order: 0.001kg
Purity: 99.99%
Supply Ability: 20MT
Release date: 2025-06-06

Wuhan JiyunZen Tech Co., Ltd.

Product: DL-Serine 302-84-1
Price: US $5.00-0.50/KG
Min. Order: 1KG
Purity: 99% hplc
Supply Ability: 500TONS
Release date: 2025-05-08

302-84-1, DL-SerineRelated Search:

3-Hydroxypropionic acid D-Cycloserine 3-(4-Hydroxyphenyl)propionic acid L(+)-Lactic acid D-Serine DL-Malic acid 3-Aminopyridine Glycine L-Homoserine L-Serine β-Alanine DIETHYL FORMAMIDOMALONATE DIETHYL BENZAMIDOMALONATE Diethyl acetamidomalonate D(-)-allo-Threonine Dimethyl nitromalonate Diethyl nitromalonate N-Cbz-L-Serine

DL-SERINE TECHNICAL GRADE

(2S)-2-ammonio-3-hydroxypropanoate

DL-SERINE extrapure CHR

DL-Serine Vetec(TM) reagent grade, 98%

DL-SERINE UNLABELED

DL-Ser-OH

DL-Serine≥ 99% (Assay)

rac-(R*)-2-Amino-3-hydroxypropionic acid

rac-(R*)-3-Hydroxy-2-aminopropionic acid

DL-Serine, extra pure

DL-3-Hydroxy-α-alanine

DL-β-Hydroxyalanine

DL-Serine, Reagent

DL-Serine, 99% 100GR

DL-Serine, 99% 25GR

DL-2-Amino-3-hydroxypropionic Acid H-DL-Ser-OH

DL-2-Aminohydracrylic acid

(R,S)-2-Amino-3-hydroxy-propionicacid

L-HOCH2CH(NH2)COOH

Serine, dl-

SERINE

(+/-)-2-AMINO-3-HYDROXYPROPIONIC ACID

2-AMINO-3-HYDROXY-PROPIONIC ACID

DL-2-AMINO-3-HYDROXYPROPANOIC ACID

DL-2-AMINO-3-HYDROXYPROPIONIC ACID

DL-BETA-HYDROXYALANINE

DL-SER

DL-SERINE

DL-SERINE CELL CULTURE TESTED

DL-SERINE 99+%

Dl-SerinePuriss99+%

Dl-SerinePuriss

DL-SERINE FOR BIOCHEMISTRY

(n)-2-amino-3-hydroxypropionic acid

DL-SERINE,FCC

H-DL-SER-OH

DL-Serin

DL-SERINE PURE GRADE

Serine, 99%, for synthesis

DL-Serine &gt

DL-SERINE FOR SYNTHESIS 100 G

threonine-protein kinase B-raf

serin

DL-Serine USP/EP/BP

dextro,laevo-serine

SERINE, (L)(302-84-1)

2-(methylamino)acetic acid (sarcosine)

C16935700 DL-Serine

DL-Serine, 10 mM in DMSO

<sc>DL</sc>-Serine

Mouse BRAF ELISA Kit

302-84-1

202-84-1

302-83-1

302-81-1

Amino Acid Derivatives

Peptide Synthesis

Specialty Synthesis