10,10-BIS(4-PYRIDINYLMETHYL)-9(10H)-ANTHRACENONE DIHYDROCHLORIDE
- Product Name
- 10,10-BIS(4-PYRIDINYLMETHYL)-9(10H)-ANTHRACENONE DIHYDROCHLORIDE
- CAS No.
- 122955-42-4
- Chemical Name
- 10,10-BIS(4-PYRIDINYLMETHYL)-9(10H)-ANTHRACENONE DIHYDROCHLORIDE
- Synonyms
- XE 991;XE9912HCl;XE991, 10 mM in DMSO;XE 991 DIHYDROCHLORIDE;10,10-Bis(pyridin-4-ylmethyl)anthracen-9(10H)-one;9(10H)-Anthracenone, 10,10-bis(4-pyridinylmethyl)-;10-bis(4-Pyridinylmethyl)-9(10H)-anthracenone dihydrochloride;10,10-BIS(4-PYRIDINYLMETHYL)-9(10H)-ANTHRACENONE DIHYDROCHLORIDE
- CBNumber
- CB7349263
- Molecular Formula
- C26H20N2O
- Formula Weight
- 376.45
- MOL File
- 122955-42-4.mol
10,10-BIS(4-PYRIDINYLMETHYL)-9(10H)-ANTHRACENONE DIHYDROCHLORIDE Property
- Melting point:
- 231-232 °C
- Boiling point:
- 585.0±38.0 °C(Predicted)
- Density
- 1.238±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: >20mg/mL
- form
- solid
- pka
- 6.08±0.10(Predicted)
- color
- white to beige
- Water Solubility
- Soluble in water (100mM)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- X2254
- Product name
- XE-991
- Purity
- ≥98% (HPLC)
- Packaging
- 10mg
- Price
- $174
- Updated
- 2024/03/01
- Product number
- X2254
- Product name
- XE-991
- Purity
- ≥98% (HPLC)
- Packaging
- 50mg
- Price
- $738
- Updated
- 2024/03/01
- Product number
- 2000
- Product name
- XE991dihydrochloride
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $780
- Updated
- 2021/12/16
- Product number
- 2000
- Product name
- XE991dihydrochloride
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $187
- Updated
- 2021/12/16
- Product number
- X750953
- Product name
- XE991
- Packaging
- 5mg
- Price
- $220
- Updated
- 2021/12/16
10,10-BIS(4-PYRIDINYLMETHYL)-9(10H)-ANTHRACENONE DIHYDROCHLORIDE Chemical Properties,Usage,Production
Uses
XE-991 has been used as a KCNQ (Kv7.2/7.3) inhibitor to examine whether M-current inhibition affects oxytocin receptor (TGOT) mediated depolarization. It has also been used as an KCNQ inhibitor to study the ionic mechanism responsible for the overshoot/undershoot in membrane potential in mouse cholinergic interneurons (ChIs) in the presence of tetrodotoxin (TTX).
Biological Activity
Potent and selective blocker of KCNQ voltage-gated potassium channels. Blocks KCNQ2+3/M-currents (IC 50 = 0.6-0.98 μ M) and KCNQ1 homomeric channels (IC 50 = 0.75 μ M) but is less potent against KCNQ1/minK channels (IC 50 = 11.1 μ M). Augments hippocampal ACh release and is a cognitive enhancer following oral administration in vivo .
Biochem/physiol Actions
XE-991 is a KCNQ channel blocker; which is more potent than linopiridine (Cat. No. L-134).
storage
Room temperature (desiccate)
10,10-BIS(4-PYRIDINYLMETHYL)-9(10H)-ANTHRACENONE DIHYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
10,10-BIS(4-PYRIDINYLMETHYL)-9(10H)-ANTHRACENONE DIHYDROCHLORIDE Suppliers
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