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ChemicalBook > CAS DataBase List > Ethylmethyl-carbamic chloride

Ethylmethyl-carbamic chloride

Uses Uses
Product Name
Ethylmethyl-carbamic chloride
CAS No.
42252-34-6
Chemical Name
Ethylmethyl-carbamic chloride
Synonyms
ETHYLMETHYLCARBAMOYL CHLORIDE;n-ethyl-n-methylcarbamoyl chloride;Bosutinib Impurity 42;Rivastigmine Intermediate 1;Ethylmethy-Carbamic Chloride;Ethylmethyl-carbamic chloride;CARBAMIC CHLORIDE, ETHYLMETHYL-;N-ethyl-N-methyl caroylchloride;N-Ethyl-N-methylcarbamic chloride;N-ethyl-n-methylcarbamyl chloride
CBNumber
CB7352742
Molecular Formula
C4H8ClNO
Formula Weight
121.57
MOL File
42252-34-6.mol
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Ethylmethyl-carbamic chloride Property

Boiling point:
89°C/40mmHg(lit.)
Density 
1.101±0.06 g/cm3(Predicted)
refractive index 
1.4500-1.4540
storage temp. 
Inert atmosphere,2-8°C
solubility 
Chloroform (Sparingly), Ethyl Acetate (Slightly)
pka
-1.85±0.70(Predicted)
form 
clear liquid
color 
Colorless to Almost colorless
Stability:
Hygroscopic
InChI
InChI=1S/C4H8ClNO/c1-3-6(2)4(5)7/h3H2,1-2H3
InChIKey
XZVYDRLPXWFRIS-UHFFFAOYSA-N
SMILES
C(Cl)(=O)N(CC)C
CAS DataBase Reference
42252-34-6(CAS DataBase Reference)
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Safety

RIDADR 
3265
HazardClass 
8
PackingGroup 
II
HS Code 
2924190015
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H290May be corrosive to metals

H314Causes severe skin burns and eye damage

Precautionary statements

P234Keep only in original container.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P390Absorb spillage to prevent material damage.

P405Store locked up.

P406Store in corrosive resistant/… container with a resistant inner liner.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
E0963
Product name
N-Ethyl-N-methylcarbamoyl Chloride
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$103
Updated
2025/07/31
TRC
Product number
E925145
Product name
N-Ethyl-N-methylcarbamoyl Chloride
Packaging
5g
Price
$185
Updated
2021/12/16
TRC
Product number
E925145
Product name
N-Ethyl-N-methylcarbamoyl Chloride
Packaging
50g
Price
$580
Updated
2021/12/16
SynQuest Laboratories
Product number
4148-5-18
Product name
Ethylmethylcarbamic chloride
Packaging
2g
Price
$25
Updated
2021/12/16
SynQuest Laboratories
Product number
4148-5-18
Product name
Ethylmethylcarbamic chloride
Packaging
5G
Price
$35
Updated
2021/12/16
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Ethylmethyl-carbamic chloride Chemical Properties,Usage,Production

Uses

N-Ethyl-N-methylcarbamoyl chloride is used as an intermediate for rivastigmine.

Uses

N-Ethyl-N-methylcarbamoyl chloride is a compound that can be used in organic synthesis.

Chemical Properties

Pale Yellow Oil

Synthesis

624-78-2

32315-10-9

42252-34-6

Example 1: A solution of N-ethylmethylamine (100 g, 1.69 mol) in dichloromethane (1.5 L) was slowly added dropwise to a suspension in dichloromethane (2 L) containing sodium bicarbonate (284 g, 3.384 mol) and triphosgene (332 g, 1.117 mol), the temperature was maintained at a controlled level of 10-15°C, and the dropwise process lasted for 2 hours. After completion of the dropwise addition, the reaction mixture was continued to be stirred at room temperature for 3 hours. Upon completion of the reaction, the resulting sodium chloride was removed by filtration and the filtrate was concentrated under reduced pressure to afford 189 g of N-methyl-N-ethylcarbamoyl chloride, the product being a light yellow oil (yield: 92%). Example 3: The procedure of Example 2 was repeated, only the solvent was changed to methylene chloride, and the rest of the reaction conditions remained unchanged. The experimental results are shown in Table 2, the yield consistently exceeded 98%.

References

[1] Patent: WO2007/80430, 2007, A1. Location in patent: Page/Page column 12; 13
[2] Research on Chemical Intermediates, 2014, vol. 40, # 2, p. 787 - 800
[3] Patent: WO2013/150529, 2013, A2. Location in patent: Page/Page column 24; 25; 28; 29
[4] Patent: WO2007/80430, 2007, A1. Location in patent: Page/Page column 13
[5] Patent: WO2007/80430, 2007, A1. Location in patent: Page/Page column 13

Ethylmethyl-carbamic chloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Ethylmethyl-carbamic chloride manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
Ethylmethyl-carbamic chloride 42252-34-6
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2025-03-11
Hebei Chuanghai Biotechnology Co,.LTD
Product
Ethylmethyl-carbamic chloride 42252-34-6
Price
US $10.00/KG
Min. Order
1KG
Purity
99.%
Supply Ability
10 ton
Release date
2024-08-20
Hangzhou ICH Biofarm Co., Ltd
Product
N,N-ETHYLMETHYL CARBAMOYL CHLORIDE 42252-34-6
Price
US $0.00-0.00/kg
Min. Order
0.1kg
Purity
99.0%min
Supply Ability
200kg
Release date
2023-06-09

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