Ethylmethyl-carbamic chloride
Uses Uses- Product Name
- Ethylmethyl-carbamic chloride
- CAS No.
- 42252-34-6
- Chemical Name
- Ethylmethyl-carbamic chloride
- Synonyms
- ETHYLMETHYLCARBAMOYL CHLORIDE;n-ethyl-n-methylcarbamoyl chloride;Bosutinib Impurity 42;Rivastigmine Intermediate 1;Ethylmethy-Carbamic Chloride;Ethylmethyl-carbamic chloride;CARBAMIC CHLORIDE, ETHYLMETHYL-;N-ethyl-N-methyl caroylchloride;N-Ethyl-N-methylcarbamic chloride;N-ethyl-n-methylcarbamyl chloride
- CBNumber
- CB7352742
- Molecular Formula
- C4H8ClNO
- Formula Weight
- 121.57
- MOL File
- 42252-34-6.mol
Ethylmethyl-carbamic chloride Property
- Boiling point:
- 89°C/40mmHg(lit.)
- Density
- 1.101±0.06 g/cm3(Predicted)
- refractive index
- 1.4500-1.4540
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- Chloroform (Sparingly), Ethyl Acetate (Slightly)
- pka
- -1.85±0.70(Predicted)
- form
- clear liquid
- color
- Colorless to Almost colorless
- Stability:
- Hygroscopic
- InChI
- InChI=1S/C4H8ClNO/c1-3-6(2)4(5)7/h3H2,1-2H3
- InChIKey
- XZVYDRLPXWFRIS-UHFFFAOYSA-N
- SMILES
- C(Cl)(=O)N(CC)C
- CAS DataBase Reference
- 42252-34-6(CAS DataBase Reference)
Safety
- RIDADR
- 3265
- HazardClass
- 8
- PackingGroup
- II
- HS Code
- 2924190015
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H290May be corrosive to metals
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P234Keep only in original container.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P390Absorb spillage to prevent material damage.
P405Store locked up.
P406Store in corrosive resistant/… container with a resistant inner liner.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- E0963
- Product name
- N-Ethyl-N-methylcarbamoyl Chloride
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $103
- Updated
- 2025/07/31
- Product number
- E925145
- Product name
- N-Ethyl-N-methylcarbamoyl Chloride
- Packaging
- 5g
- Price
- $185
- Updated
- 2021/12/16
- Product number
- E925145
- Product name
- N-Ethyl-N-methylcarbamoyl Chloride
- Packaging
- 50g
- Price
- $580
- Updated
- 2021/12/16
- Product number
- 4148-5-18
- Product name
- Ethylmethylcarbamic chloride
- Packaging
- 2g
- Price
- $25
- Updated
- 2021/12/16
- Product number
- 4148-5-18
- Product name
- Ethylmethylcarbamic chloride
- Packaging
- 5G
- Price
- $35
- Updated
- 2021/12/16
Ethylmethyl-carbamic chloride Chemical Properties,Usage,Production
Uses
N-Ethyl-N-methylcarbamoyl chloride is used as an intermediate for rivastigmine.
Uses
N-Ethyl-N-methylcarbamoyl chloride is a compound that can be used in organic synthesis.
Chemical Properties
Pale Yellow Oil
Synthesis
624-78-2
32315-10-9
42252-34-6
Example 1: A solution of N-ethylmethylamine (100 g, 1.69 mol) in dichloromethane (1.5 L) was slowly added dropwise to a suspension in dichloromethane (2 L) containing sodium bicarbonate (284 g, 3.384 mol) and triphosgene (332 g, 1.117 mol), the temperature was maintained at a controlled level of 10-15°C, and the dropwise process lasted for 2 hours. After completion of the dropwise addition, the reaction mixture was continued to be stirred at room temperature for 3 hours. Upon completion of the reaction, the resulting sodium chloride was removed by filtration and the filtrate was concentrated under reduced pressure to afford 189 g of N-methyl-N-ethylcarbamoyl chloride, the product being a light yellow oil (yield: 92%). Example 3: The procedure of Example 2 was repeated, only the solvent was changed to methylene chloride, and the rest of the reaction conditions remained unchanged. The experimental results are shown in Table 2, the yield consistently exceeded 98%.
References
[1] Patent: WO2007/80430, 2007, A1. Location in patent: Page/Page column 12; 13
[2] Research on Chemical Intermediates, 2014, vol. 40, # 2, p. 787 - 800
[3] Patent: WO2013/150529, 2013, A2. Location in patent: Page/Page column 24; 25; 28; 29
[4] Patent: WO2007/80430, 2007, A1. Location in patent: Page/Page column 13
[5] Patent: WO2007/80430, 2007, A1. Location in patent: Page/Page column 13
Ethylmethyl-carbamic chloride Preparation Products And Raw materials
Raw materials
Preparation Products
Ethylmethyl-carbamic chloride Suppliers
- Tel
- 320-37350700
- Fax
- +32 (0)37350701
- sales@tcieurope.eu
- Country
- Europe
- ProdList
- 23671
- Advantage
- 75
- Tel
- --
- Fax
- --
- Sales@kemikalieimport.dk
- Country
- Europe
- ProdList
- 6685
- Advantage
- 47
View Lastest Price from Ethylmethyl-carbamic chloride manufacturers
- Product
- Ethylmethyl-carbamic chloride 42252-34-6
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2025-03-11
- Product
- Ethylmethyl-carbamic chloride 42252-34-6
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99.%
- Supply Ability
- 10 ton
- Release date
- 2024-08-20
- Product
- N,N-ETHYLMETHYL CARBAMOYL CHLORIDE 42252-34-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.1kg
- Purity
- 99.0%min
- Supply Ability
- 200kg
- Release date
- 2023-06-09