S-ETHYL TRIFLUOROTHIOACETATE Property

Boiling point:

90.5 °C(lit.)

Density 

1.234 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.376(lit.)

Flash point:

39 °F

storage temp. 

Store at RT.

form 

clear liquid

color 

Colorless to Light yellow

BRN 

1761564

CAS DataBase Reference

383-64-2(CAS DataBase Reference)

EPA Substance Registry System

Ethanethioic acid, trifluoro-, S-ethyl ester (383-64-2)

Safety

Hazard Codes 

F,Xi

Risk Statements 

11-36/37/38

Safety Statements 

16-26-36

RIDADR 

UN 3272 3/PG 2

WGK Germany 

3

F 

3-9-13-21

Hazard Note 

Flammable/Irritant

HazardClass 

3.1

PackingGroup 

II

HS Code 

2918300090

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

S-ETHYL TRIFLUOROTHIOACETATE Chemical Properties,Usage,Production

Chemical Properties

clear colorless to slightly yellow liquid

Uses

S-Ethyl trifluorothioacetate was used to selectively trifluoroacetylate amino groups in proteins.

Synthesis Reference(s)

Journal of the American Chemical Society, 74, p. 4005, 1952 DOI: 10.1021/ja01136a010

Purification Methods

If IR is free of OH bands then fractionally distil it; otherwise dilute the thio-ester with dry Et2O, wash with 5% KOH and H2O, dry over MgSO4 and fractionate it through an efficient column [Hauptschein et al. J Am Chem Soc 74 4005 1952]. [Beilstein 2 IV 567.] Powerful obnoxious odour.