4-Fluoro-3-nitrobenzyl bromide
- Product Name
- 4-Fluoro-3-nitrobenzyl bromide
- CAS No.
- 15017-52-4
- Chemical Name
- 4-Fluoro-3-nitrobenzyl bromide
- Synonyms
- 3-NITRO-4-FLUOROBENZYLBROMIDE;4-FLUORO-3-NITROBENZYL BROMIDE;4-Fluoro-3-NitrobenzylBromide96%;4-(BROMOMETHYL)-1-FLUORO-2-NITROBENZENE;Benzene, 4-(bromomethyl)-1-fluoro-2-nitro-;4-Fluoro-3-nitrobenzyl bromide ISO 9001：2015 REACH
- CBNumber
- CB7357020
- Molecular Formula
- C7H5BrFNO2
- Formula Weight
- 234.02
- MOL File
- 15017-52-4.mol
4-Fluoro-3-nitrobenzyl bromide Property
- Melting point:
- 84-86°C
- Boiling point:
- 317.4±27.0 °C(Predicted)
- Density
- 1.733±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- solid
- color
- Pale yellow
- CAS DataBase Reference
- 15017-52-4(CAS DataBase Reference)
Safety
- Hazard Codes
- C,Xn
- Risk Statements
- 34-36/37/38-22
- Safety Statements
- 26-36/37/39
- RIDADR
- 1759
- HS Code
- 2904990090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P363Wash contaminated clothing before reuse.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- F401628
- Product name
- 4-Fluoro-3-nitrobenzylBromide
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- F401628
- Product name
- 4-Fluoro-3-nitrobenzylBromide
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 119408
- Product name
- 4-(Bromomethyl)-1-fluoro-2-nitrobenzene
- Purity
- 95+%
- Packaging
- 5g
- Price
- $108
- Updated
- 2021/12/16
- Product number
- 119408
- Product name
- 4-(Bromomethyl)-1-fluoro-2-nitrobenzene
- Purity
- 95+%
- Packaging
- 10g
- Price
- $162
- Updated
- 2021/12/16
- Product number
- HCH0023791
- Product name
- 4-FLUORO-3-NITROBENZYL BROMIDE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $600.79
- Updated
- 2021/12/16
4-Fluoro-3-nitrobenzyl bromide Chemical Properties,Usage,Production
Uses
scaffold molecule for combinatorial synthesis
Synthesis
20274-69-5
15017-52-4
General procedure for the synthesis of 4-fluoro-3-nitrobenzyl bromide from 3-nitro-4-fluorobenzyl alcohol: 1. in a dry reaction flask, phosphorus tribromide (1.13 mL) was slowly added dropwise to a solution of 4-fluoro-3-nitrobenzyl alcohol (2.1 g, 11.23 mmol) in anhydrous ether (40 mL). 2. Stir the reaction mixture at room temperature for 1 hour until the reaction is complete. 3. After the reaction is complete, carefully add water to the reaction mixture to quench the reaction. 4. The reaction mixture was extracted with ethyl acetate (3 × 20 mL) and the organic phases were combined. 5. The organic phase was washed sequentially with saturated sodium bicarbonate solution (20 mL) and saturated brine (20 mL). 6. The organic phase was dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to obtain the crude product. 7. The crude product was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate, gradient elution) to obtain 4-fluoro-3-nitrobenzyl bromide (2.50 g, 95% yield) as a light yellow solid. Product Characterization: 1H NMR (270 MHz, CDCl3) δ (ppm): 8.10 (dd, 1H, J = 7.1, 2.2 Hz), 7.67 (m, 1H), 7.29 (dd, 1H, J = 10.7, 8.6 Hz), 4.49 (s, 2H).
References
[1] Patent: EP1982982, 2008, A1. Location in patent: Page/Page column 199
[2] Patent: KR101511396, 2015, B1. Location in patent: Paragraph 2917-2921
[3] Journal of the Chemical Society - Series Chemical Communications, 1994, # 4, p. 439 - 440
[4] Heterocycles, 1999, vol. 51, # 9, p. 2041 - 2063
[5] Tetrahedron, 2011, vol. 67, # 33, p. 6073 - 6082
4-Fluoro-3-nitrobenzyl bromide Preparation Products And Raw materials
Raw materials
Preparation Products
4-Fluoro-3-nitrobenzyl bromide Suppliers
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- export@ecochem.dk
- Country
- Europe
- ProdList
- 6371
- Advantage
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View Lastest Price from 4-Fluoro-3-nitrobenzyl bromide manufacturers
- Product
- 4-Fluoro-3-nitrobenzyl bromide 15017-52-4
- Price
- US $100.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-25
- Product
- 4-Fluoro-3-nitrobenzyl bromide 15017-52-4
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 4-Fluoro-3-nitrobenzyl bromide 15017-52-4
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09