1-Boc-Pyrrolidine

Product Name: 1-Boc-Pyrrolidine
CAS No.: 86953-79-9
Chemical Name: 1-Boc-Pyrrolidine
Synonyms: N-Boc;NT 0186;1-BOC-PYRROLIDINE;n-boc-pyrrolidine;N-1-BOC-Pyrrolidone;N-T-BOC-PYRROLIDINE;N-T-Boc-Pyrrolidone;N-Boc-pyrrolidine 97%;1-Boc-pyrrolidine,96%;N-tert-Boc-Pyrrolidine
CBNumber: CB7361768
Molecular Formula: C9H17NO2
Formula Weight: 171.24
MOL File: 86953-79-9.mol

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1-Boc-Pyrrolidine Property

Boiling point:: 80 °C/0.2 mmHg (lit.)
Density: 0.977 g/mL at 25 °C (lit.)
refractive index: n20/D 1.449(lit.)
Flash point:: 187 °F
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Chloroform, Methanol
form: Oil
pka: -1.28±0.20(Predicted)
color: Clear Colorless
BRN: 4664750
InChI: InChI=1S/C9H17NO2/c1-9(2,3)12-8(11)10-6-4-5-7-10/h4-7H2,1-3H3
InChIKey: LPQZERIRKRYGGM-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCCC1
CAS DataBase Reference: 86953-79-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
RIDADR: NA 1993 / PGIII
WGK Germany: 3
Hazard Note: Irritant
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 427055
Product name: N-Boc-pyrrolidine
Purity: 97%
Packaging: 10g
Price: $157
Updated: 2025/07/31

TCI Chemical

Product number: B3971
Product name: 1-tert-Butoxycarbonylpyrrolidine
Purity: >98.0%(GC)
Packaging: 5g
Price: $61
Updated: 2025/07/31

TCI Chemical

Product number: B3971
Product name: 1-tert-Butoxycarbonylpyrrolidine
Purity: >98.0%(GC)
Packaging: 25g
Price: $191
Updated: 2025/07/31

TRC

Product number: B665850
Product name: N-Boc-pyrrolidine
Packaging: 50g
Price: $165
Updated: 2021/12/16

Usbiological

Product number: 239973
Product name: N-Boc-
Packaging: 25mg
Price: $305
Updated: 2021/12/16

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1-Boc-Pyrrolidine Chemical Properties,Usage,Production

Chemical Properties

liquid

Uses

N-Boc-pyrrolidine may be used in the synthesis of the following:

2-aryl-N-boc-pyrrolidines
scalemic 2-pyrrolidinylcuprates
2-alkenyl-N-Boc-pyrrolidines
1-deoxycastanospermine
methylphenidate analogues
(+)-elaeokanine A

Uses

1-Boc-pyrrolidine is a boc-protected cyclic amine used as a building block in the preparation of diastereomers by usually undergoing α'-lithiations and electrophilic substitution reactions.

General Description

N-Boc-pyrrolidine is an N-substituted pyrrolidine. It is reported that the reactivity of N-Boc-pyrrolidine towards C-H insertion reaction is 2000 times more than cyclohexane. It undergoes α-arylation in the presence of a palladium catalyst with high enantioselectivity.

Synthesis

123-75-1

24424-99-5

86953-79-9

The general procedure for the synthesis of 1-Boc-tetrandrine from tetrandrine and di-tert-butyl dicarbonate is as follows: the synthesis was carried out by a modified literature method (omitting the Sparteine chiral ligand), as specified in J. Am. Chem. Soc. 1994, 116, 3231.The steps are as follows: A) Preparation of Boc-protected pyrrolidines Triethylamine (TEA, 15.6 g, 0.15 mol) was slowly added to a dichloromethane (DCM, 150 mL) solution of pyrrolidine (10.0 g, 0.14 mol) in stirring at 0 °C. Subsequently, di-tert-butyl dicarbonate ((Boc)2O, 30.6 g, 0.14 mol) was added, and the reaction mixture was stirred at room temperature for 1 hour. The progress of the reaction was monitored by thin layer chromatography (TLC) to confirm complete pyrrolidine consumption. Upon completion of the reaction, the reaction mixture was washed sequentially with 1 M aqueous hydrochloric acid (100 mL) and brine, and the organic phase was dried over anhydrous sodium sulfate (Na2SO4), filtered, and concentrated under reduced pressure to afford the colorless, oily product 1-Boc-tetrandrine (24.0 g, 100%), which could be used in the subsequent steps without further purification.

References

[1] Tetrahedron Letters, 2008, vol. 49, # 16, p. 2527 - 2532
[2] Patent: WO2013/102242, 2013, A1. Location in patent: Page/Page column 94; 95
[3] Tetrahedron Letters, 2007, vol. 48, # 47, p. 8318 - 8322
[4] Journal of the American Chemical Society, 2017, vol. 139, # 24, p. 8267 - 8276
[5] Synthesis, 2001, # 4, p. 550 - 552

1-Boc-Pyrrolidine Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Boc-Pyrrolidine Suppliers

Americas 1 Canada 2 China 167 Europe 2 France 1 Germany 7 India 8 Japan 2 Slovakia 1 Switzerland 1 The Netherlands 1 United Kingdom 9 United States 28 Global 230

Carbosynth

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Carbosynth Limited

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VWR International

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View Lastest Price from 1-Boc-Pyrrolidine manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 1-Boc-Pyrrolidine 86953-79-9
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-26

Shaanxi Dideu Medichem Co. Ltd

Product: 1-Boc-Pyrrolidine 86953-79-9
Price: US $0.10/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 1000Tons
Release date: 2024-08-04

Career Henan Chemical Co

Product: 1-Boc-Pyrrolidine 86953-79-9
Price: US $500.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2018-08-04

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86953-79-9

56953-79-9

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