4-(pyridine-2-yl) pyrimidin-2-amine

Product Name: 4-(pyridine-2-yl) pyrimidin-2-amine
CAS No.: 66521-65-1
Chemical Name: 4-(pyridine-2-yl) pyrimidin-2-amine
Synonyms: BUTTPARK 41\09-82;Nilotinib Impurity 9(N-Oxide);Nilotinib 2-Pyridinyl Impurity;2-Amino-4-(2-pyridyl)pyrimidine;4-(2-PYRIDINYL)-2-PYRIMIDINAMINE;4-(PYRIDIN-2-YL)PYRIMIDIN-2-AMINE;2-Pyrimidinamine, 4-(2-pyridinyl)-;4-(2-pyridinyl)-2-pyrimidinylamine;2-amino-4-(2-pyridinyl)-pyrimidine;4-(pyridine-2-yl) pyrimidin-2-amine
CBNumber: CB7364224
Molecular Formula: C9H8N4
Formula Weight: 172.19
MOL File: 66521-65-1.mol

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4-(pyridine-2-yl) pyrimidin-2-amine Property

Melting point:: 137-139°C
Boiling point:: 426.5±37.0 °C(Predicted)
Density: 1.259±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 3.34±0.10(Predicted)
form: Solid
color: Off-White to Pale Yellow

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Safety

Hazard Codes: Xn
Risk Statements: 22
HazardClass: IRRITANT
HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: P991695
Product name: 4-(2-Pyridinyl)-2-pyrimidinamine
Packaging: 50mg
Price: $80
Updated: 2021/12/16

TRC

Product number: P991695
Product name: 4-(2-Pyridinyl)-2-pyrimidinamine
Packaging: 100mg
Price: $120
Updated: 2021/12/16

TRC

Product number: P991695
Product name: 4-(2-Pyridinyl)-2-pyrimidinamine
Packaging: 250mg
Price: $275
Updated: 2021/12/16

Matrix Scientific

Product number: 042500
Product name: 4-(2-Pyridinyl)-2-pyrimidinamine
Purity: >95%
Packaging: 1g
Price: $288
Updated: 2021/12/16

AK Scientific

Product number: 0219AC
Product name: 4-(Pyridin-2-yl)pyrimidin-2-amine
Packaging: 1g
Price: $381
Updated: 2021/12/16

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4-(pyridine-2-yl) pyrimidin-2-amine Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

Intermediate in the preparation of Nilotinib.

Preparation

Synthesis of 4-(pyridine-2-yl) pyrimidin-2-amine (P2P). (0.5 g, 2.84 mmol) of (Z)-3- dimethylamino-1-(pyridine-2-yl)prop-2-en-1-one was suspended was suspended in 15ml of nbutanol. To the solution (0.346 g, 2.84 mmol) of guanidine nitrate added and followed by the addition of NaOH(0.114 g, 2.84 mmol) and reflux this mixture at 110℃ for 12h. After completion of the reaction the mixture was filtered, the clear yellow solution of filtrate kept for room temperature. After 20 min yellow crystal formed and dried in a vacuum under reduced pressure. Yield (0.296 g, 60%) IR (KBr): 3471, 3142, 1622, 1568, 1463, 1340, 1215, 1095, 993, 783, 650, 524.1H NMR (300 MHz, CDCl3) δ 8.69 (dd, J = 11.9, 10.0 Hz, 1H), 8.45 (dd, J = 5.1, 2.6 Hz, 1H), 8.40 – 8.20 (m, 1H), 7.85 (ddd, J = 17.9, 9.4, 7.3 Hz, 1H), 7.64 (dd, J = 5.1, 2.8 Hz, 1H), 7.53 – 7.30 (m, 1H), 5.30 (s, 2H). 13C NMR (75 MHz, CDCl3) δ 164.49 (s), 163.75 (s), 159.65 (s), 154.75 (s), 149.79 (s), 137.29 (s), 125.41 (s), 121.87 (s), 108.26 (s).

4-(pyridine-2-yl) pyrimidin-2-amine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-(pyridine-2-yl) pyrimidin-2-amine manufacturers

Dideu Industries Group Limited

Product: 4-(2-PYRIDINYL)-2-PYRIMIDINAMINE 66521-65-1
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons
Release date: 2022-02-10

66521-65-1, 4-(pyridine-2-yl) pyrimidin-2-amineRelated Search:

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4-(2-PYRIDINYL)-2-PYRIMIDINAMINE

4-(PYRIDIN-2-YL)PYRIMIDIN-2-AMINE

BUTTPARK 41\09-82

Nilotinib 2-Pyridinyl Impurity

Nilotinib Impurity 9(N-Oxide)

4-(2-pyridinyl)-2-pyrimidinylamine

4-(2-pyridinyl)-2-pyrimidinamine (en)

2-amino-4-(2-pyridinyl)-pyrimidine

2-Amino-4-(2-pyridyl)pyrimidine

2-Pyrimidinamine, 4-(2-pyridinyl)-

4-(2-PYRIDINYL)-2-PYRIMIDINAMINE ISO 9001：2015 REACH

4-(pyridine-2-yl) pyrimidin-2-amine

66521-65-1

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