4-(pyridine-2-yl) pyrimidin-2-amine
- Product Name
- 4-(pyridine-2-yl) pyrimidin-2-amine
- CAS No.
- 66521-65-1
- Chemical Name
- 4-(pyridine-2-yl) pyrimidin-2-amine
- Synonyms
- BUTTPARK 41\09-82;Nilotinib Impurity 9(N-Oxide);Nilotinib 2-Pyridinyl Impurity;2-Amino-4-(2-pyridyl)pyrimidine;4-(2-PYRIDINYL)-2-PYRIMIDINAMINE;4-(PYRIDIN-2-YL)PYRIMIDIN-2-AMINE;2-Pyrimidinamine, 4-(2-pyridinyl)-;4-(2-pyridinyl)-2-pyrimidinylamine;2-amino-4-(2-pyridinyl)-pyrimidine;4-(pyridine-2-yl) pyrimidin-2-amine
- CBNumber
- CB7364224
- Molecular Formula
- C9H8N4
- Formula Weight
- 172.19
- MOL File
- 66521-65-1.mol
4-(pyridine-2-yl) pyrimidin-2-amine Property
- Melting point:
- 137-139°C
- Boiling point:
- 426.5±37.0 °C(Predicted)
- Density
- 1.259±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 3.34±0.10(Predicted)
- form
- Solid
- color
- Off-White to Pale Yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- P991695
- Product name
- 4-(2-Pyridinyl)-2-pyrimidinamine
- Packaging
- 50mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- P991695
- Product name
- 4-(2-Pyridinyl)-2-pyrimidinamine
- Packaging
- 100mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- P991695
- Product name
- 4-(2-Pyridinyl)-2-pyrimidinamine
- Packaging
- 250mg
- Price
- $275
- Updated
- 2021/12/16
- Product number
- 042500
- Product name
- 4-(2-Pyridinyl)-2-pyrimidinamine
- Purity
- >95%
- Packaging
- 1g
- Price
- $288
- Updated
- 2021/12/16
- Product number
- 0219AC
- Product name
- 4-(Pyridin-2-yl)pyrimidin-2-amine
- Packaging
- 1g
- Price
- $381
- Updated
- 2021/12/16
4-(pyridine-2-yl) pyrimidin-2-amine Chemical Properties,Usage,Production
Chemical Properties
Off-White Solid
Uses
Intermediate in the preparation of Nilotinib.
Preparation
Synthesis of 4-(pyridine-2-yl) pyrimidin-2-amine (P2P). (0.5 g, 2.84 mmol) of (Z)-3- dimethylamino-1-(pyridine-2-yl)prop-2-en-1-one was suspended was suspended in 15ml of nbutanol. To the solution (0.346 g, 2.84 mmol) of guanidine nitrate added and followed by the addition of NaOH(0.114 g, 2.84 mmol) and reflux this mixture at 110℃ for 12h. After completion of the reaction the mixture was filtered, the clear yellow solution of filtrate kept for room temperature. After 20 min yellow crystal formed and dried in a vacuum under reduced pressure. Yield (0.296 g, 60%) IR (KBr): 3471, 3142, 1622, 1568, 1463, 1340, 1215, 1095, 993, 783, 650, 524.1H NMR (300 MHz, CDCl3) δ 8.69 (dd, J = 11.9, 10.0 Hz, 1H), 8.45 (dd, J = 5.1, 2.6 Hz, 1H), 8.40 – 8.20 (m, 1H), 7.85 (ddd, J = 17.9, 9.4, 7.3 Hz, 1H), 7.64 (dd, J = 5.1, 2.8 Hz, 1H), 7.53 – 7.30 (m, 1H), 5.30 (s, 2H). 13C NMR (75 MHz, CDCl3) δ 164.49 (s), 163.75 (s), 159.65 (s), 154.75 (s), 149.79 (s), 137.29 (s), 125.41 (s), 121.87 (s), 108.26 (s).
4-(pyridine-2-yl) pyrimidin-2-amine Preparation Products And Raw materials
Raw materials
Preparation Products
4-(pyridine-2-yl) pyrimidin-2-amine Suppliers
- Tel
- --
- Fax
- --
- interchim@interchim.com
- Country
- France
- ProdList
- 6302
- Advantage
- 76
View Lastest Price from 4-(pyridine-2-yl) pyrimidin-2-amine manufacturers
- Product
- 4-(2-PYRIDINYL)-2-PYRIMIDINAMINE 66521-65-1
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons
- Release date
- 2022-02-10