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2-Acetylphenothiazine

Product Name
2-Acetylphenothiazine
CAS No.
6631-94-3
Chemical Name
2-Acetylphenothiazine
Synonyms
2-APT;ML 171;2-Acetylphenothiazin;2-ACETYLPHENOTHIAZINE;NOX1 Inhibitor, ML171;LABOTEST-BB LT00012652;2-Acetyl-10H-phenothiazine;2-Acetylphenothiazine(ML171);methyl phenothiazin-2-yl ketone;Ethanone, 1-(10H-phenothiazin-2-yl)-
CBNumber
CB7368424
Molecular Formula
C14H11NOS
Formula Weight
241.31
MOL File
6631-94-3.mol
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2-Acetylphenothiazine Property

Melting point:
180-185 °C (lit.)
Boiling point:
455.7±34.0 °C(Predicted)
Density 
1.249±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly, Heated)
pka
-2.45±0.20(Predicted)
form 
Dark yellow-orange powder
color 
Yellow to Dark Orange
λmax
244nm(MeOH)(lit.)
CAS DataBase Reference
6631-94-3(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-52/53
Safety Statements 
60-61
WGK Germany 
3
HS Code 
2934309090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
175226
Product name
2-Acetylphenothiazine
Purity
95%
Packaging
25g
Price
$225
Updated
2024/03/01
Sigma-Aldrich
Product number
175226
Product name
2-Acetylphenothiazine
Purity
95%
Packaging
100g
Price
$319.2
Updated
2024/03/01
TCI Chemical
Product number
A2815
Product name
2-Acetylphenothiazine
Purity
>98.0%(GC)
Packaging
5g
Price
$197
Updated
2024/03/01
TCI Chemical
Product number
A2815
Product name
2-Acetylphenothiazine
Purity
>98.0%(GC)
Packaging
25g
Price
$572
Updated
2024/03/01
Cayman Chemical
Product number
19056
Product name
2-Acetylphenothiazine
Purity
≥98%
Packaging
10g
Price
$32
Updated
2024/03/01
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2-Acetylphenothiazine Chemical Properties,Usage,Production

Description

2-Acetylphenothiazine (2-APT) is a selective, cell-active inhibitor of NADPH oxidase 1 (NOX1) that blocks the generation of reactive oxygen species (ROS) in HT-29 cells with an IC50 value of 0.129 μM. It does not affect xanthine oxidase-dependent or mitochondrial ROS generation. 2-APT prevents ROS-dependent formation of ECM-degrading invadopodia in colon cancer cells. It also abolishes collagen-induced superoxide production by platelets (IC50 = 306 nM), preventing platelet aggregation and thrombus formation. 2-APT protects beta cells from cytokine-induced apoptosis by inhibiting NOX1. 2-APT can also activate the human transient receptor potential ankyrin 1 (TRPA1) nociceptor at 1-30 μM.

Chemical Properties

Yellow white or green crystalline powder

Uses

2-Acetylphenothiazine is a potent and selective NADPH oxidase 1 (NOX1) inhibitor that blocks NOX1-dependent ROS generation. 2-Acetylphenothiazine has been shown to inhibit SrcYF-induced invadopodia formation in human DLD1 colon cancer cells.

Uses

2-Acetylphenothiazine was used as a NADPH oxidase (NOX) inhibitor in human platelet functional responses and intracellular signaling pathways. It was also used in the synthesis of 2-phenothiazin-2′-yl-cinchoninic acid derivatives.

Definition

ChEBI: 1-(10H-phenothiazin-2-yl)ethanone is a member of phenothiazines.

2-Acetylphenothiazine Preparation Products And Raw materials

Raw materials

Preparation Products

ACETOPHENAZINE MALEATE (200 MG)
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2-Acetylphenothiazine Suppliers

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View Lastest Price from 2-Acetylphenothiazine manufacturers

Career Henan Chemical Co
Product
2-Acetylphenothiazine 6631-94-3
Price
US $1.00/ASSAYS
Min. Order
1ASSAYS
Purity
85.0-99.8%
Supply Ability
20tons
Release date
2020-01-08

6631-94-3, 2-Acetylphenothiazine Related Search:

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  • 2-ACETYLPHENOTHIAZINE
  • methyl phenothiazin-2-yl ketone
  • 2-Acetyl-10H-phenothiazine
  • 2-Acetylphenothiazin
  • 1-(10H-Phenothiazin-2-yl)ethan-1- one, 2-Ethanoyl-10H-phenothiazine
  • ML 171
  • LABOTEST-BB LT00012652
  • NOX1 Inhibitor, ML171
  • 2-Acetylphenothiazine(ML171)
  • NOX1 Inhibitor, ML171 - CAS 6631-94-3 - Calbiochem
  • 2-APT
  • Ethanone, 1-(10H-phenothiazin-2-yl)-
  • 6631-94-3
  • C14H11NOS
  • Thiazines
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