(ACETYLMETHYLENE)TRIPHENYLPHOSPHORANE

Product Name: (ACETYLMETHYLENE)TRIPHENYLPHOSPHORANE
CAS No.: 1439-36-7
Chemical Name: (ACETYLMETHYLENE)TRIPHENYLPHOSPHORANE
Synonyms: 1-(TRIPHENYLPHOSPHORANYLIDENE)-2-PROPANONE;(2-Oxopropylidene)triphenylphosphorane;NSC 407394;1-(TriphenyL;phosphoranyL;AURORA KA-1177;idene)-2-propanone;Triphenyl(acetylMethylene)phospho;(Acetonylidene)triphenylphosphorane;(Triphenylphosphoranylidene)acetone
CBNumber: CB7371857
Molecular Formula: C21H19OP
Formula Weight: 318.35
MOL File: 1439-36-7.mol

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(ACETYLMETHYLENE)TRIPHENYLPHOSPHORANE Property

Melting point:: 203-205 °C (lit.)
Boiling point:: 478.5±28.0 °C(Predicted)
Density: 1.14
storage temp.: Inert atmosphere,Room Temperature
solubility: Soluble in chloroform. Slightly soluble in methanol.
form: Powder
color: White to off-white
Sensitive: Air Sensitive
BRN: 750077
Stability:: Stable. Combustible. Incompatible with strong oxidizing agents.
CAS DataBase Reference: 1439-36-7(CAS DataBase Reference)

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Safety

Risk Statements: 22-36/37/38
Safety Statements: 22-24/25
WGK Germany: 3
RTECS: UC3900000
HS Code: 29319090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 158755
Product name: 1-(Triphenylphosphoranylidene)-2-propanone
Purity: 99%
Packaging: 25g
Price: $197
Updated: 2024/03/01

Sigma-Aldrich

Product number: 158755
Product name: 1-(Triphenylphosphoranylidene)-2-propanone
Purity: 99%
Packaging: 100g
Price: $444.6
Updated: 2024/03/01

TCI Chemical

Product number: A1439
Product name: (Acetylmethylene)triphenylphosphorane
Purity: >98.0%(GC)
Packaging: 25g
Price: $89
Updated: 2024/03/01

Alfa Aesar

Product number: A11410
Product name: (Acetylmethylene)triphenylphosphorane, 99%
Packaging: 10g
Price: $45.65
Updated: 2024/03/01

Alfa Aesar

Product number: A11410
Product name: (Acetylmethylene)triphenylphosphorane, 99%
Packaging: 50g
Price: $153.65
Updated: 2024/03/01

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(ACETYLMETHYLENE)TRIPHENYLPHOSPHORANE Chemical Properties,Usage,Production

Chemical Properties

white to light beige crystalline powder

Uses

(Acetylmethylene)triphenylphosphorane is used as a Wittig reagent in synthetic chemistry, especially for the synthesis of functionalized pyrrolidines and cyclobutanones. It plays as a vital role in asymmetric allylboration for enantioselective synthesis of (+)-awajanomycin.It is also employed as a reactant in the preparation of 1,2-dioxanes with antitrypanosomal activity. Further, it is used in the preparation of amphibian pyrrolizidine alkaloids through allylic aminations and silicon-containing acyclic dienone musk odorants. In addition to this, it is involved in Domino Suzuki/Heck coupling reactions to prepare fluorenylidenes.

Synthesis

The preparative method of (Acetylmethylene)triphenylphosphorane: treatment of Triphenylphosphine with chloro- or Bromoacetone provides the phosphonium salt (eq 1). Deprotonation with a weak base such as bicarbonate in cold water provides the crude ylide which may by isolated by filtration.

storage

Handling, Storage, and Precautions: may be handled in atmosphere for short periods; will decompose in water at pH > 9.

(ACETYLMETHYLENE)TRIPHENYLPHOSPHORANE Preparation Products And Raw materials

Raw materials

Preparation Products

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(ACETYLMETHYLENE)TRIPHENYLPHOSPHORANE Suppliers

Americas 1 Austria 1 Belgium 3 Canada 2 China 153 Europe 2 France 4 Germany 7 India 12 Japan 4 Switzerland 2 The Netherlands 2 Ukraine 1 United Kingdom 14 United States 29 Global 237

Integrity（Anhui）Biopharma Co., Ltd.

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Shanghai Carlow Chemicals Co., Ltd.

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Creasyn Finechem(Tianjin) Co., Ltd.

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Qingxian Creasyn Pharmaceutical Technology Co., Ltd.

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J & K SCIENTIFIC LTD.

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Meryer (Shanghai) Chemical Technology Co., Ltd.

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Beijing Donghualituo Techonlogy Development Co.,Ltd.

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Alfa Aesar

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TCI (Shanghai) Development Co., Ltd.

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Ark Pharm, Inc.

Tel: 847-367-3680
Fax: 847-367-3681
Email: sales@arkpharminc.com
Country: United States
ProdList: 1670
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View Lastest Price from (ACETYLMETHYLENE)TRIPHENYLPHOSPHORANE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: (AcetylMethylene)triphenylphosphorane 1439-36-7
Price: US $1.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 tons
Release date: 2020-01-15

Career Henan Chemical Co

Product: (ACETYLMETHYLENE)TRIPHENYLPHOSPHORANE 1439-36-7
Price: US $3.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2019-07-09

1439-36-7, (ACETYLMETHYLENE)TRIPHENYLPHOSPHORANERelated Search:

6-broMo-8-cyclopentyl-5-Methyl-2-(5-(piperazin-1-yl)pyridin-2-ylaMino)pyrido[2,3-d]pyriMidin-7(8H)-one PalBociclib Impurity 17 PalBociclib Impurity 24 Palbociclib Impurity 15 Pyrido[2,3-d]pyriMidin-7(8H)-one, 2,6-dibroMo-8-cyclopentyl-5-Methyl- 2-chloro-4-(cyclopentylamino)-5-pyrimidinyl ethanone PalBociclib Impurity 23 Palbociclib-012 PalBociclib Impurity 25 Pyrido[2,3-d]pyriMidin-7(8H)-one, 8-cyclopentyl-5-Methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]aMino]- PalBociclib Impurity 14 8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-6-vinylpyrido[2,3-d]pyrimidin-7(8H)-one tert-Butyl 4-(6-((6-(1-butoxyvinyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate PalBociclib Impurity 22 Palbociclib Impurity 20 Palbociclib Impurity 10 Palbociclib Impurity 2 PalBociclib Impurity 11

(METHYLCARBONYLMETHYLENE)TRIPHENYLPHOSPHORANE

(ACETYLMETHYLENE)TRIPHENYLPHOSPHORANE

1-TRIPHENYLPHOSPHANYLIDENE-PROPAN-2-ONE

1-(TRIPHENYLPHOSPHORANYLIDENE)-2-PROPANONE

triphenylphosphoranylidene-2-propanon

AURORA KA-1177

(Triphenylphosphoranylidene)acetone 98%

triphenylphosphoranylidene-2-propanone

1-(triphenylphosphoranylidene)acetone

2-Propanone, 1-(triphenylphosphoranylidene)-

(Acetylylmethylene)triphenylphosphorane, 99 %

2-Propanone, triphenylphosphoranylidene.

(2-Oxopropylidene)triphenylphosphorane

Triphenyl(2-oxopropylidene)phosphorane

1-Triphenylphosphoranylidene-2-propanone,99%

(Acetonylidene)triphenylphosphorane

Methyl (Triphenylphosphoranylidene)Methyl Ketone

NSC 407394

Triphenyl(acetylMethylene)phospho

1-(Triphenylphosphoranylidene)propan-2-one

ACETYLMETHYLENETRIPHENYLPHOSPHORANE FOR

(Acetylmethylene)triphenylphosphorane, 1-(Triphenylphosphoranylidene)propan-2-one

(Triphenylphosphoranylidene)acetone

(Acetylylmethylene)triphenylphosphorane

1-Triphenylphosphoranylidene-2-propanone, 99% 25GR

Acetyl Methylene triphenylphosphine

1-Triphenylphosphoranylidine-2-propanone

1-(TriphenyL

idene)-2-propanone

phosphoranyL

1-(Triphenylphosphoranylidene)-2-propanone 99%

Acetylmethylenetriphenylphosphorane for synthesis

(Acetylmethylene)triphenylphosphorane &gt

1-Triphenylphosphoranylidene-2-propanone, 98%, for synthesis

1-(Triphenylphosphoranyliden)aceton

1439-36-7

C21H19OP

C21H19PO

CH3COCHPC6H53

Olefination

Synthetic Reagents

Wittig Reagents

C-C Bond Formation

Wittig & Horner-Emmons Reaction

Wittig Reaction

Wittig Reagents

Synthetic Organic Chemistry

Wittig & Horner-Emmons Reaction

Wittig Reaction