3-BROMO-2-CHLOROQUINOLINE

Product Name: 3-BROMO-2-CHLOROQUINOLINE
CAS No.: 101870-60-4
Chemical Name: 3-BROMO-2-CHLOROQUINOLINE
Synonyms: 3-BROMO-2-CHLOROQUINOLINE;Quinoline, 3-bromo-2-chloro-
CBNumber: CB7374601
Molecular Formula: C9H5BrClN
Formula Weight: 242.5
MOL File: 101870-60-4.mol

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3-BROMO-2-CHLOROQUINOLINE Property

Melting point:: 96-98 °C
Boiling point:: 311.2±22.0 °C(Predicted)
Density: 1.673±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
pka: -2.14±0.50(Predicted)
Appearance: Light yellow to yellow Solid

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Safety

HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B415475
Product name: 3-Bromo-2-chloroquinoline
Packaging: 500mg
Price: $130
Updated: 2021/12/16

TRC

Product number: B415475
Product name: 3-Bromo-2-chloroquinoline
Packaging: 100mg
Price: $60
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-D-39
Product name: 3-Bromo-2-chloroquinoline
Packaging: 5G
Price: $450
Updated: 2021/12/16

AK Scientific

Product number: Y6812
Product name: 3-Bromo-2-chloroquinoline
Packaging: 1g
Price: $131
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-D-39
Product name: 3-Bromo-2-chloroquinoline
Packaging: 1g
Price: $140
Updated: 2021/12/16

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3-BROMO-2-CHLOROQUINOLINE Chemical Properties,Usage,Production

Synthesis

939-16-2

101870-60-4

General procedure for the synthesis of 3-bromo-2-chloroquinoline from 3-bromoquinolin-2(1H)-one: Phosphorus trichloride (3.42 g, 22.28 mmol) was slowly added dropwise to a stirred suspension of 3-bromo-1H-quinolin-2-one (4.16 g, 18.57 mmol) in acetonitrile (30 mL) at room temperature. The reaction mixture was heated to reflux for 3 hours. Upon completion of the reaction, it was cooled to room temperature, the reaction solution was carefully poured into crushed ice (70 mL) and the pH was adjusted to 9 with 10% potassium carbonate solution (40 mL).The resulting precipitate was collected by filtration, washed with water and dried under vacuum to afford 3-bromo-2-chloroquinoline as a white solid (4.00 g, 89% yield) with a melting point of 101-103 °C (literature value: 96-98 °C). The product was confirmed by 1H NMR (DMSO-d6, 400 MHz): δ 8.95 (s, 1H), 8.03 (d, 1H, J = 8.0 Hz), 7.98 (d, 1H, J = 8.8 Hz), 7.90-7.84 (m, 1H), 7.74-7.69 (m, 1H); 13C NMR (DMSO-d6, 400 MHz ) confirmed: δ 148.1, 145.4, 142.1, 131.3, 128.1, 127.8, 127.6, 127.2, 115.6. Elemental analysis (C9H5BrClN, Mr = 242.50): calculated values C 44.58, H 2.08, N 5.78; measured values C 44.46, H 2.07, N 5.79. LCMS (ESI+) m/z 242, 244 [M+H]+.

References

[1] Tetrahedron, 2013, vol. 69, # 45, p. 9512 - 9519
[2] Organic and Biomolecular Chemistry, 2016, vol. 14, # 40, p. 9622 - 9628

3-BROMO-2-CHLOROQUINOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-BROMO-2-CHLOROQUINOLINE Suppliers

China 52 Germany 2 India 1 United States 9 Global 64

J & K SCIENTIFIC LTD.

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View Lastest Price from 3-BROMO-2-CHLOROQUINOLINE manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 3-BROMO-2-CHLOROQUINOLINE 101870-60-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-27

101870-60-4, 3-BROMO-2-CHLOROQUINOLINERelated Search:

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3-BROMO-2-CHLOROQUINOLINE

Quinoline, 3-bromo-2-chloro-

101870-60-4