KT5823

ChemicalBook > CAS DataBase List > KT5823

Product Name: KT5823
CAS No.: 126643-37-6
Chemical Name: KT5823
Synonyms: KT5823;KT 5283;KT5823;KT-5823;KT5823, inhibitor of PKG;PROTEIN KINASE INHIBITOR KT 5823;KT5823 - CAS 126643-37-6 - Calbiochem;9-Methoxy-9-methoxycarbonyl-8-methyl-2,3,9,10-tetrahydro-8,11-epxoy-1H,8H,11H-2,7B-11A-triazadibenzo(A,G)cycloocta(cde)-trinden-1-one;(9R)-2,3,9,10,11,12-Hexahydro-10β-methoxy-2,9-dimethyl-1-oxo-9α,12α-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid methyl ester;(9S,10R,12R)-2,3,9,10,11,12-Hexahydro-10-methoxy-2,9-dimethyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, methyl ester;(9S, 10R, 12R)-2,3,9,10,11,12-HEXAHYDRO-10-METHOXY-2,9-DIMETHYL-1-OXO-9,12-EPOXY-1H-DIINDOLO[1,2,3-FG:3',2',1'-KL]PYRROLO[3,4-I][1,6]BENZODIAZOCINE-10-CARBOXYLIC ACID, METHYL ESTER
CBNumber: CB7377637
Molecular Formula: C29H25N3O5
Formula Weight: 495.53
MOL File: 126643-37-6.mol

Less

KT5823 Property

Boiling point:: 629.2±55.0 °C(Predicted)
Density: 1.52±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: ethyl acetate: 5 mg/mL
form: lyophilized powder
pka: -1.01±0.60(Predicted)
color: white
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20° for up to 3 months.

Less

Safety

Hazard Codes: Xi
WGK Germany: 3
F: 10
HS Code: 29349990

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 420321
Product name: KT5823 - CAS 126643-37-6 - Calbiochem
Purity: Highly specific, cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase G (Ki = 234 nM).
Packaging: 50μg
Price: $159
Updated: 2024/03/01

Sigma-Aldrich

Product number: K1388
Product name: KT 5823
Purity: ≥85% (HPLC), lyophilized powder
Packaging: 100μg
Price: $219
Updated: 2024/03/01

Sigma-Aldrich

Product number: 420321
Product name: KT5823 - CAS 126643-37-6 - Calbiochem
Purity: Highly specific, cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase G (Ki = 234 nM).
Packaging: 100μg
Price: $259
Updated: 2024/03/01

Cayman Chemical

Product number: 10010965
Product name: KT 5823
Purity: ≥95%
Packaging: 25μg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 10010965
Product name: KT 5823
Purity: ≥95%
Packaging: 50μg
Price: $68
Updated: 2024/03/01

Less

KT5823 Chemical Properties,Usage,Production

Description

KT5823 (126643-37-6) is a selective protein kinase G inhibitor (K>i =0.23, 4 and >10 μM for PKG, PKC and PKA respectively.1?Arrests human skin fibroblast cell cycle after the G0/G1 boundary.2 KT5823 abolishes the cGMP-induced relaxation in smooth muscle cells (IC50=60 nM).3?Cell permeable.

Chemical Properties

Yellow powder

Uses

KT 5823 is a protein kinase inhibitor shown to increase TSH-induced NIS expression, and thus iodide uptake, in thyroid cells.

Uses

KT 5823 has been used as cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG) inhibitor in cortical cultures, cortical neurons and in mouse brain capillary endothelial cells.

Definition

ChEBI: KT 5823 is an organic heterooctacyclic compound that is 1H,1'H-2,2'-biindole in which the nitrogens have undergone formal oxidative coupling to positions 2 and 5 of methyl (3R)-3-methoxy-2-methyltetrahydrofuran-3-carboxylate (the 2S,3R,5R product), and in which the 3 and 3' positions of the biindole moiety have also undergone formal oxidative coupling to positions 3 and 4 of 1-methyl-1,5-dihydro-2H-pyrrol-2-one. It has a role as an EC 2.7.11.12 (cGMP-dependent protein kinase) inhibitor. It is a gamma-lactam, an organic heterooctacyclic compound, a methyl ester, a hemiaminal and an indolocarbazole.

General Description

Highly specific cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase G (K_i = 234 nM). Inhibits protein kinase C (K_i = 4.0 μM) and protein kinase A (K_i >10.0 μM) at higher concentrations.

Biological Activity

Selective inhibitor of protein kinase G (K i values are 0.23, 4 and > 10 μ M for inhibition of PKG, PKC and PKA respectively). Inhibits SNP-stimulated PKG activity with an IC 50 of 60 nM in dispersed smooth muscle cells and has little effect on PKA activity at concentrations of up to 10 μ M. Also available as part of the Mixed Kinase Inhibitor Tocriset™ .

Biochem/physiol Actions

Cell permeable: yes

storage

-20°C (desiccate)

References

1) Kase et al. (1987), K252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases; Biochem. Biophys. Res. Commun., 142 436 2) Gadbois et al. (1992), Multiple kinase arrest points in the G1 phase of nontransformed mammalian cells are absent in transformed cells; Proc. Natl. Acad. Sci. USA, 89 8626 3) Murthy et al. (1995), Interaction of cA-kinase and cG-kinase in mediating relaxation of dispersed smooth muscle cells; Am. J. Physiol., 268 C171

KT5823 Preparation Products And Raw materials

Raw materials

Preparation Products

Less

KT5823 Suppliers

China 81 Europe 1 Germany 6 Japan 3 Switzerland 3 United Kingdom 6 United States 21 Global 121

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 13675144456
Fax: 025-85563444
Email: sean.lv@synzest.com
Country: China
ProdList: 11438
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15402
Advantage: 60

Hunan Hui Bai Shi Biotechnology Co., Ltd.

Tel: 0731-85526065 13308475853
Email: ivy@hnhbsj.com
Country: China
ProdList: 4554
Advantage: 62

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-400-6206333 18521732826
Fax: 021-50323701
Email: market@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3466
Advantage: 58

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51456
Advantage: 80

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 27313
Advantage: 60

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12306
Advantage: 58

Shandong Ono Chemical Co., Ltd.

Tel: 0539-6362799 20）
Fax: 0539-6362799（To 20）
Country: China
ProdList: 9998
Advantage: 58

DC Chemicals

Tel: 021-58447131 13564518121
Email: sales@dcchemicals.com
Country: China
ProdList: 9409
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: 029-81024372 15029046529
Fax: 029-88380327
Email: 1027@dideu.com
Country: China
ProdList: 10010
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44806
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
Advantage: 58

Lingyuan Bebiansen Biological Technology Co., Ltd

Tel: 18642120371
Email: 2837458851@qq.com
Country: China
ProdList: 7995
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29774
Advantage: 58

Hebei Zhentian Food Additives Co., Ltd.

Tel: 0319-5925599 13373390591
Fax: 0319 5925599
Email: 13933732699@163.com
Country: China
ProdList: 12185
Advantage: 58

Shanghai Universal Biotech Co.,Ltd

Tel: 13774214275
Email: zhouzz@univ-bio.com
Country: China
ProdList: 24995
Advantage: 58

Shangqiu Ladybug Network Technology Co., LTD

Tel: 17550092151
Fax: 03702782809
Email: 3628320093@qq.com
Country: China
ProdList: 4206
Advantage: 58

Hebei Zhentian food additives Co., LTD

Tel: 0319-5925599 13373390591
Email: 13933732699@163.com
Country: China
ProdList: 12269
Advantage: 58

bioleaper

Tel: 4000880777 17585207275
Email: guojing@bioleaper.com
Country: China
ProdList: 5616
Advantage: 58

Hubei Danding Pharmaceutical Technology Co., Ltd

Tel: 18917019315 18917019315
Email: 18917019315@163.cn
Country: China
ProdList: 9159
Advantage: 58

ZHEJIANG JIUZHOU CHEM CO., LTD

Tel: +86-0576225566889 +86-13454675544
Email: admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com
Country: China
ProdList: 12272
Advantage: 58

Shanghai Xiyuan Biotechnology Co., Ltd

Tel: --
Fax: --
Email: shxiyuanbio@163.com
Country: CHINA
ProdList: 6934
Advantage: 58

Shanghai Hao Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: shxiyuanbio@163.com
Country: CHINA
ProdList: 6906
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6650
Advantage: 58

Beijing Sizhengbai Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: marketing@4abio.com
Country: CHINA
ProdList: 6401
Advantage: 58

Changzhou Beiyuanxin Biological Technology Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 4375
Advantage: 58

Beijing Luyuan Bird Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 15810802415@139.com
Country: CHINA
ProdList: 6750
Advantage: 58

Jiangxi Jianglan Pure Biological Reagent Co., Ltd.

Tel: --
Fax: --
Email: 3245176082@qq.com
Country: CHINA
ProdList: 6134
Advantage: 58

Beijing Taize Jiaye Technology Development Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 6050
Advantage: 58

Dongguan Biaobiao Experimental Equipment Technology Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 6672
Advantage: 58

Beijing Dongge Boye Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 1861586486@qq.com
Country: CHINA
ProdList: 6648
Advantage: 58

Shanghai Haoran Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 470003480@QQ.COM
Country: CHINA
ProdList: 6955
Advantage: 58

Annuol (Beijing) Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: inquiry@annoron.com
Country: CHINA
ProdList: 6434
Advantage: 58

Beijing Baiao Innovation Technology Co., Ltd.

Tel: --
Fax: --
Email: 3007606172@qq.com
Country: CHINA
ProdList: 6002
Advantage: 58

Beijing Fubo Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: info@f-biology.com
Country: CHINA
ProdList: 6025
Advantage: 58

Shanghai Weiwei Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: sales@wheybio.com
Country: CHINA
ProdList: 4398
Advantage: 58

Beijing baierdi biotechnology co. LTD

Tel: --
Fax: --
Email: biodee2012@126.com
Country: CHINA
ProdList: 1773
Advantage: 58

Beijing Dakco is Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: bj_info@dakewe.net
Country: CHINA
ProdList: 6348
Advantage: 58

Shanghai Haoyang Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: 596799915@QQ.COM
Country: CHINA
ProdList: 2905
Advantage: 58

Beijing Shengke Boyuan Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 978560024@qq.com
Country: CHINA
ProdList: 6005
Advantage: 58

Shanghai Yubo Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 344843571@qq.com
Country: CHINA
ProdList: 6318
Advantage: 58

Shenzhen Branch Science and Technology Co., Ltd.

Tel: --
Fax: --
Email: zikerbio@163.com
Country: CHINA
ProdList: 6478
Advantage: 58

Beijing Bai Ao Si Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: yangmei@bioneeds.net
Country: CHINA
ProdList: 6999
Advantage: 58

Beijing Chief-East Tech Co.,Ltd (Qwbio)

Tel: --
Fax: --
Email: info@qwbio.com
Country: China
ProdList: 6912
Advantage: 50

Shanghai Weiwei Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: tech@chinabiovision.com
Country: CHINA
ProdList: 2731
Advantage: 58

126643-37-6, KT5823Related Search:

ZM 336372 STO-609 (acetate) Sunitinib Malate GW5074 ANTI-ANDROGEN RECEPTOR KT5823 (semi-synthetic derivative of K525a), Selective PKG Inhibitor, 0.4955kD KT5823 (Selective PKG Inhibitor) 11,12-Dihydroindolo[2,3-a]carbazole Lestaurtinib 9-CARBAZOLEPROPIONIC ACID K-252C KT5823 1-(1-METHYL-1H-INDOL-4-YL)METHYLAMINE 97 9-ISOPROPYLCARBAZOLE K-252A CARBAZOL-9-YL-METHANOL

PROTEIN KINASE INHIBITOR KT 5823

9,12-Epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-methoxy-2,9-dimethyl-1-oxo-, methyl ester, (9S,10R,12R)-

(9S, 10R, 12R)-2,3,9,10,11,12-HEXAHYDRO-10-METHOXY-2,9-DIMETHYL-1-OXO-9,12-EPOXY-1H-DIINDOLO[1,2,3-FG:3',2',1'-KL]PYRROLO[3,4-I][1,6]BENZODIAZOCINE-10-CARBOXYLIC ACID, METHYL ESTER

KT5823

(9S,10R,12R)-2,3,9,10,11,12-Hexahydro-10-methoxy-2,9-dimethyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, methyl ester

(9R)-2,3,9,10,11,12-Hexahydro-10β-methoxy-2,9-dimethyl-1-oxo-9α,12α-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid methyl ester

9,12-Epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-I)(1,6)benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-methoxy-2,9-dimethyl-1-oxo-, methyl ester, (9R-(9alpha,10beta,12alpha))-

9,12-Epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-I)(1,6)benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-methoxy-2,9-dimethyl-1-oxo-, methyl ester, (9R,10R,12R)-

9-Methoxy-9-methoxycarbonyl-8-methyl-2,3,9,10-tetrahydro-8,11-epxoy-1H,8H,11H-2,7B-11A-triazadibenzo(A,G)cycloocta(cde)-trinden-1-one

KT 5283

KT5823;KT-5823

KT5823 - CAS 126643-37-6 - Calbiochem

KT5823, inhibitor of PKG

126643-37-6

C29H25N3O5

BioChemical

Cell Biology

Cell Signaling and Neuroscience

Serine/Threonine Kinase Inhibitors

Kinase/Phosphatase Biology

Protein Kinase G (PKG)

Cyclic Nucleotide related

antibiotic

Protein Kinase G (PKG)Cell Signaling and Neuroscience

Enzyme Inhibitors by Enzyme

Kinase/Phosphatase Biology

P to

Protein kinase CSerine/Threonine Kinase Biology

Protein Kinase Inhibitors

Serine/Threonine Kinase Inhibitors