1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHATIDYL-RAC-GLYCEROL, NA SALT
- Product Name
- 1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHATIDYL-RAC-GLYCEROL, NA SALT
- CAS No.
- 124011-52-5
- Chemical Name
- 1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHATIDYL-RAC-GLYCEROL, NA SALT
- Synonyms
- 1,2-Distearoyl-rac-glycero-3-PG (sodium salt);(Rac)-1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol sodium;1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHATIDYL-RAC-GLYCEROL, NA SALT;sodium 2,3-bis(stearoyloxy)propyl (2,3-dihydroxypropyl) phosphate;1,2-distearoyl-sn-glycero-3-phosphatidyl-rac-glycerol sodium salt;Octadecanoic acid,1-[[[(2,3-dihydroxypropoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl ester,sodium salt
- CBNumber
- CB7380181
- Molecular Formula
- C42H84NaO10P
- Formula Weight
- 803.09
- MOL File
- 124011-52-5.mol
1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHATIDYL-RAC-GLYCEROL, NA SALT Property
- solubility
- Chloroform:2.0(Max Conc. mg/mL);2.5(Max Conc. mM)
- form
- A crystalline solid
N-Bromosuccinimide Price
- Product number
- 15087
- Product name
- 1,2-Distearoyl-rac-glycero-3-PG (sodium salt)
- Purity
- ≥98%
- Packaging
- 100 mg
- Price
- $82
- Updated
- 2024/03/01
- Product number
- 15087
- Product name
- 1,2-Distearoyl-rac-glycero-3-PG (sodium salt)
- Purity
- ≥98%
- Packaging
- 250 mg
- Price
- $194
- Updated
- 2024/03/01
- Product number
- 15087
- Product name
- 1,2-Distearoyl-rac-glycero-3-PG (sodium salt)
- Purity
- ≥98%
- Packaging
- 500 mg
- Price
- $368
- Updated
- 2024/03/01
1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHATIDYL-RAC-GLYCEROL, NA SALT Chemical Properties,Usage,Production
Description
DSPG is used in FDA approved drugs. It is an anionic phospholipid derivative. DSPG has been used to form an ionic complex with amphotericin B and encapsulate it into small unilamellar liposomes with significantly reduced toxicity (AmBisome?). DSPG-Na is a lipid reagent, which is useful in drug formulation, DNA & RNA delivery.
in vitro
Three liposome formulations were investigated: HSPC:Chol (L-EPI; 5:4 molar ratio), HSPC:Chol:DSPG (D-EPI; 5:4:1 molar ratio), and HSPC:Chol:DSPG:DSPE-mPEG(2000) (S-EPI; 5:4:1:0.3 molar ratio). Small unilamellar liposomes were prepared by the modified thin-film hydration method with extrusion through polycarbonate filters, and EPI was remote loaded into liposomes by the transmembrane ammonium sulfate gradient method._x000D_ _x000D_ Reference: J Liposome Res. 2012 Mar;22(1):80-8. https://pubmed.ncbi.nlm.nih.gov/22022836/
in vivo
Vaccination of atherosclerotic mice on a western-type diet with DSPG-liposomes encapsulating an LDL-derived peptide antigen significantly reduced plaque formation by 50% and stabilized the plaques, and reduced serum cholesterol concentrations. These results indicate that DSPG-liposomes have potential as a delivery system in vaccination against atherosclerosis._x000D_ _x000D_ Reference: J Control Release. 2018 Dec 10;291:135-146. https://pubmed.ncbi.nlm.nih.gov/30365993/
target
A phospholipid.