Minoxidil

ChemicalBook > CAS DataBase List > Minoxidil

an antihypertensive vasodilator medication Indications and Usage Mechanisms of Action Adverse reactions Contradictions

Product Name: Minoxidil
CAS No.: 38304-91-5
Chemical Name: Minoxidil
Synonyms: Minoxidil Base;pdp;Minoxidil powder;2,4-diamino-6-piperidinopyrimidine3-n-oxide;rogaine;minoxidi;Minoxidil CRS;4-pyrimidinediamine;Minoxidil for system suitability;Minoxidil for system suitability CRS
CBNumber: CB7383531
Molecular Formula: C9H15N5O
Formula Weight: 209.25
MOL File: 38304-91-5.mol

Less

Minoxidil Property

Melting point:: 272-274 °C (dec.) (lit.)
Boiling point:: 348.61°C (rough estimate)
Density: 1.1651 (rough estimate)
refractive index: 1.7610 (estimate)
storage temp.: 2-8°C
solubility: Slightly soluble in water, soluble in methanol and in propylene glycol.
pka: 4.61(at 25℃)
form: Solid
color: White
Water Solubility: Soluble in water (2.2 mg/ml), 100% ethanol (29 mg/ml), propylene glycol, acetone, DMSO (6.5 mg/ml), and methanol.
Merck: 14,6203
BCS Class: 3
Stability:: Stable for 2 years from date of purchase as supplied. Protect from moisture. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChIKey: ZFMITUMMTDLWHR-UHFFFAOYSA-N
CAS DataBase Reference: 38304-91-5(CAS DataBase Reference)
NIST Chemistry Reference: Minoxidil(38304-91-5)

Less

Safety

Hazard Codes: Xn,T+
Risk Statements: 22-36/37/38-26/27/28
Safety Statements: 26-36-45-36/37/39-22
WGK Germany: 3
RTECS: UV8200000
HS Code: 29335990
Hazardous Substances Data: 38304-91-5(Hazardous Substances Data)
Toxicity: LD50 in rats, mice (mg/kg): 49, 51 i.v. (Carlson, Feenstra)

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: M4145
Product name: Minoxidil
Purity: ≥99% (TLC)
Packaging: 25mg
Price: $88.8
Updated: 2024/03/01

Sigma-Aldrich

Product number: PHR2123
Product name: Minoxidil
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 200MG
Price: $186
Updated: 2024/03/01

Sigma-Aldrich

Product number: BP637
Product name: Minoxidil
Purity: British Pharmacopoeia (BP) Reference Standard
Packaging: 100MG
Price: $262
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1444208
Product name: Minoxidil
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 125mg
Price: $358
Updated: 2024/03/01

TCI Chemical

Product number: M1389
Product name: Minoxidil
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $33
Updated: 2024/03/01

Less

Minoxidil Chemical Properties,Usage,Production

an antihypertensive vasodilator medication

Minoxidil is an antihypertensive vasodilator medication also claiming to slow or stop hair loss and promote hair regrowth. It is available over the counter for treatment of androgenic alopecia, among other baldness treatments, but measurable changes, if experienced, disappear within months after discontinuation of treatment.
Minoxidil was first sold as a drug for high blood pressure and was noted to have the interesting side-effect of increased body hair-growth, or in some cases, significant hair loss. Treatments for baldness and hair loss usually include a 5% concentration solution that is designed for men, whereas the 2% concentration solutions are designed for women.

Indications and Usage

Minoxidil is a type of oral drug that is clinically used to lower blood pressure, and it is also called Loniten and piperidine diamine. Minoxidil is an antihypertensive drug that is clinically used to treat intractable, primary or renal hypertension. It can also be used to treat severe hypertension that does not respond well to other antihypertensive drugs, but it needs to be used in combination with diuretic drugs to prevent water and sodium retention, and combined use with beta receptor blockers may increase its curative effects and reduce adverse effects. Minoxidil is also used to prevent grease-type alopecia and on livestock.

Mechanisms of Action

Minoxidil is a type of potassium channel opener and can directly relax smooth vascular muscles and has a strong small artery dilating effect. It can reduce peripheral resistance, dilate blood vessels, and lower blood pressure while having no effect on blood volume, thus promoting venous return. In addition, due to reflective regulation and positive frequency effects, it can increase cardiac output and heart rate, but will not cause orthostatic hypotension.

Adverse reactions

Long term use of Minoxidil may have the side effect of increased body hair, such as arm hair.
Adverse reactions to oral intake mainly include: weight gain and lower body swelling due to water and sodium retention, heart palpitations and arrhythmia due to reflexive sympathetic nervous excitement, and hirsuitism.
Adverse reactions to external use mainly include: skin irritation, red spots in applied areas, itching, and other skin inflammation reactions. Although only a small amount is absorbed, but there is also a slight possibility of causing a recurrence in patients with a history or heart disease. Use with caution if suffering from cerebrovascular disease, non-hypertensive heart failure, coronary heart disease, angina pectoris, myocardial infarction, pericardial effusion, renal dysfunction and other diseases.

Contradictions

Do not use if allergic to Minoxidil or suffering from pheochromocytoma.

Description

Minoxidil is a peripheral vasodilator that directly relaxes vascular smooth musculature, thus, lowering systolic and diastolic pressure. Its action is linked to the activation of calcium channels. Open calcium channels cause hyperpolarization of smooth muscle cells, which in turn, reduces the flow of calcium ions into the cell, which is necessary for supporting vascular tonicity. However, when taking minoxidil, tachycardia, elevated renin secretion, and water and sodium ion retention all appear simultaneously with hypotension.

Chemical Properties

White Crystalline Solid

Originator

Loniten ,Upjohn ,US ,1979

Uses

Used as an antihypertensive and antialopecia agent. Minoxidil activates ATP-activated K+ channels

Uses

A selective ATP dependent K+ (Kir6) channel activator

Definition

ChEBI: Minoxidil is a pyrimidine N-oxide that is pyrimidine-2,4-diamine 3-oxide substituted by a piperidin-1-yl group at position 6. It has a role as a vasodilator agent and an antihypertensive agent. It is a pyrimidine N-oxide, a member of piperidines and an aminopyrimidine.

Manufacturing Process

Barbituric acid is reacted with phosphorus oxychloride then with 2,4,6-trichloropyrimidine and that product with ammonia to give 4-chloro-2,6-diaminopyritnidine.
A 30 g (0.15 mol) quantity of 4-chloro-2,6-diaminopyrimidine is dissolved in600 ml of hot 3A alcohol, the solution cooled to 0°C to 10°C and 41.8 g (0.24mol) of m-chloroperbenzoic acid is added. The mixture is held at 0°C to 10°Cfor 4 hours and filtered. The solid is shaken for 2 hours in 0.24 mol of 10%sodium hydroxide and filtered. The solid is washed with water and dried toyield 193 g of crude product. This product is extracted for 1 hour with 900 mlof boiling acetonitrile to yield 14.8 g (44.7% yield) of 6-amino-4-chloro-1,2-dihydro-1-hydroxy-2-iminopyrimidine, melting point 193°C.
A mixture of 3.0 g (0.019 mol) of 6-amino-4-chloro-1,2-dihydro-1-hydroxy-2-iminopyrimidine and 35 ml of piperidine is refluxed for 1.5 hours, cooled andfiltered. The solid is shaken for 20 minutes in a solution of 0.8 g of sodiumhydroxide in 30 ml of water and filtered. The solid is washed with water andextracted with 800 ml of boiling acetonitrile and filtered to yield 3.5 g (89%)yield of 6-amino-4-chloro-1,2-dihydro-1-hydroxy-2-iminopyrimidine, meltingpoint 248°C, decomposition at 259°C to 261°C.

brand name

Loniten (Pharmacia & Upjohn); Rogaine (Pharmacia & Upjohn); Minodyl (Quantum Pharmics).

Therapeutic Function

Antihypertensive

General Description

Minoxidil, 2,4-diamino-6-piperidinopyrimidine-3-oxide . It is converted to minoxidil sulfate in the liver bya sulfotransferase enzyme.
The antihypertensive properties of minoxidil are similarto those of hydralazine hydrochloride, in that minoxidil candecrease arteriolar vascular resistance. Minoxidil exerts itsvasodilatory action by a direct effect on arteriolar smoothmuscle and appears to have no effect on the CNS or on theadrenergic nervous system in animals. The serum half-lifeis 4.5 hours, and the antihypertensive effect may last up to24 hours.

Biological Activity

Antihypertensive. Antialopecia agent. K + channel (K ATP ) activator.

Biochem/physiol Actions

Activates ATP-activated K+ channels; vasodilator; slow or stop hair loss and promote hair regrowth.

Mechanism of action

Potassium channel openers are drugs that activate (i.e., open) ATP-sensitive K+ channels in the VSM. By opening these potassium channels, there is increased efflux of potassium ions from the cells, causing hyperpolarization of VSM, which closes the voltage-gated calcium channels and, thereby, decreases intracellular calcium. With less calcium available to combine with calmodulin, there is less activation of MLCK and phosphorylation of myosin light chains. This leads to relaxation and vasodilation. Because small arteries and arterioles normally have a high degree of smooth muscle tone, these drugs are particularly effective in dilating these resistance vessels, decreasing systemic vascular resistance, and lowering arterial pressure. The fall in arterial pressure leads to reflex cardiac stimulation (baroreceptor-mediated tachycardia).
Minoxidil, as its active metabolite minoxidil O-sulfate, prolongs the opening of the potassium channel, sustaining greater vasodilation on arterioles than on veins. The drug decreases blood pressure in both the supine and standing positions, and there is no orthostatic hypotension. Associated with the decrease in peripheral resistance and blood pressure is a reflex response that is accompanied by increased heart rate, cardiac output, and stroke volume, which can be attenuated by the coadministration of a β-blocker. Along with this decrease in peripheral resistance is increased plasma renin activity and sodium and water retention, which can result in expansion of fluid volume, edema, and congestive heart failure. The sodium- and water-retaining effects of minoxidil can be reversed by coadministration of a diuretic. When minoxidil is used in conjunction with a β-adrenergic blocker, pulmonary artery pressure remains essentially unchanged.

Pharmacokinetics

Minoxidil is absorbed from the GI tract and is metabolized to its active sulfate metabolite. Plasma concentrations for minoxidil sulfate peak within 1 hour and then decline rapidly. Following an oral dose of minoxidil, its hypotensive effect begins in 30 minutes, is maximal in 2 to 8 hours, and persists for approximately 2 to 5 days. The delayed onset of the hypotensive effect for minoxidil is attributed to its metabolism to its active metabolite. The drug is not bound to plasma proteins. The major metabolite for minoxidil is its N-O-glucuronide, which unlike the sulfate metabolite is inactive as a hypotensive agent. Approximately 10 to 20% of an oral dose of minoxidil is metabolized to its active metabolite, minoxidil O-sulfate, and approximately 20% of minoxidil is excreted unchanged.

Clinical Use

Minoxidil is used for severe hypertension that is difficultto control with other antihypertensive agents. The drug hassome of the characteristic side effects of direct vasodilatorydrugs. It causes sodium and water retention and may requirecoadministration of a diuretic. Minoxidil also causes reflextachycardia, which can be controlled by use of a -adrenergicblocking agent.
Minoxidil topical solution is used to treat alopecia androgenitica(male-pattern baldness). Although the mechanismis not clearly understood, topical minoxidil is believed to increasecutaneous blood flow, which may stimulate hairgrowth. The stimulation of hair growth is attributed to vasodilationin the vicinity of application of the drug, resultingin better nourishment of the local hair follicles.

Side effects

Adverse reactions include local irritation and contact dermatitis. If the treatment is discontinued, clinical regression occurs within 3 months to the state of hair thinning that would have occurred had the treatment not been started. Twice-daily treatment is more efficacious than once-daily application. Women who use the5%concentrationmay note the development of facial hair, which is reversible on discontinuation of the medication. The 5% concentration can be more irritating than the 2% solution.

Synthesis

Minoxidil, 6-amino-1,2-dihydro-1-hydroxy-2-imino-4-piperidinopyrimidine (22.8.5), is synthesized from barbituric acid, the reaction of which with phosphorous oxychloride gives 2,4,6-trichloropyrimidine (22.8.1). Upon reaction with ammonium, this turns into 2,4-diamino-6-chloropyrimidine (22.8.2). Next, the resulting 2,4-diamino-6- chloropyrimidine (22.8.2) undergoes reaction with 2,4-dichlorophenol in the presence of potassium hydroxide, giving 2,4-diamino-6-(2,4-dichlorophenoxy)-pyrimidine (22.8.3). Oxidation of this product with 3-chloroperbenzoic acid gives 2,4-diamino-6-(2,4- dichlorophenoxy)pyrimidine-3-oxide (22.8.4), the 2,4-dichlorophenoxyl group of which is replaced with a piperidine group at high temperature, giving minoxidil (22.8.5).

Drug interactions

When minoxidil is administered with diuretics or other hypotensive drugs, the hypotensive effect of minoxidil increases, and concurrent use may cause profound orthostatic hypotensive effects.

Metabolism

Extensively metabolised by the liver. It requires sulphation to become active, but the major metabolite is a glucuronide conjugate. Excreted mainly in the urine in the form of metabolites. Minoxidil and its metabolites are dialysable, although the pharmacological effect is not reversed.

storage

Room temperature

References

1) Meisheri et al. (1988), Mechanism of action of minoxidil sulfate-induced vasodilation: a role for increased K+ permeability; J. Pharmacol. Exp. Ther., 245 7 2) Messenger and Rundegren (2004) Minoxidil:mechanisms of action on hair growth; Br. J. Dermatol., 150 186

Minoxidil Preparation Products And Raw materials

Raw materials

2,6-Diaminopyridine Perbenzoic acid Piperidine 4-Chloropyrimidine Methyl cyanoacetate

Preparation Products

Less

Minoxidil Suppliers

Americas 1 Australia 1 Canada 4 China 630 Europe 4 France 1 Germany 5 India 45 Italy 4 Japan 3 Singapore 1 South Korea 1 Spain 1 Switzerland 4 United Kingdom 12 United States 62 Global 779

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
Email: sales@chemreagents.com
Country: United States
ProdList: 10186
Advantage: 62

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2782
Advantage: 58

HBCChem, Inc.

Tel: +1-510-219-6317
Fax: +1-650-486-1361
Email: sales@hbcchem.com
Country: United States
ProdList: 10648
Advantage: 60

Alfa Chemistry

Tel: 1-516-6625404
Fax: 1-516-927-0118
Email: support@alfa-chemistry.com
Country: United States
ProdList: 9171
Advantage: 60

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8447
Advantage: 60

Alfa Chemistry

Tel
Fax: 1-516-927-0118
Email: Info@alfa-chemistry.com
Country: United States
ProdList: 24072
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

Cato Research Chemicals Inc.

Tel: 020-81215950 4000-868-328
Email: customer@uwalab.com
Country: United States
ProdList: 10404
Advantage: 58

Protheragen-ING

Tel: +16313385890
Email: info@protheragen-ing.com
Country: United States
ProdList: 3868
Advantage: 58

TargetMol Chemicals Inc.

Tel: +8613564774135
Email: zijue.cai@tsbiochem.com
Country: United States
ProdList: 19885
Advantage: 58

TargetMol Chemicals Inc.

Tel
Email: support@targetmol.com
Country: United States
ProdList: 38631
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

United States Biological

Tel: --
Fax: --
Email: sales@advtechind.com
Country: United States
ProdList: 6075
Advantage: 58

ApexBio Technology

Tel: --
Fax: --
Email: sales@apexbt.com
Country: United States
ProdList: 6251
Advantage: 58

Alfa Chemistry

Tel: --
Fax: --
Email: info@Alfa-Chemistry.com
Country: United States
ProdList: 6814
Advantage: 0

CarboMer, Inc.

Tel: --
Fax: --
Email: sales@carbomer.com
Country: United States
ProdList: 4026
Advantage: 67

Focus Biomolecules

Tel: --
Fax: --
Email: sales@focusbiomolecules.com
Country: United States
ProdList: 1284
Advantage: 58

Wintersun International Inc.

Tel: --
Fax: --
Email: orders@wintersunchem.com
Country: United States
ProdList: 191
Advantage: 58

Cayman Chemical Company

Tel: --
Fax: --
Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
Advantage: 81

MedChemExpress

Tel: --
Fax: --
Email: sales@medchemexpress.com
Country: United States
ProdList: 6398
Advantage: 58

Combi-Blocks Inc.

Tel: --
Fax: --
Email: sales@combi-blocks.com
Country: United States
ProdList: 6618
Advantage: 69

Riedel-de Haen AG

Tel: --
Fax: --
Country: United States
ProdList: 6773
Advantage: 87

TCI America

Tel: --
Fax: --
Email: sales@tciamerica.com
Country: United States
ProdList: 6909
Advantage: 75

Frontier Scientific, Inc.

Tel: --
Fax: --
Email: sales@frontiersci.com
Country: United States
ProdList: 6222
Advantage: 86

Matrix Scientific

Tel: --
Fax: --
Email: sales@matrixscientific.com
Country: United States
ProdList: 6632
Advantage: 80

Olinax Inc.

Tel: --
Fax: --
Email: info@olinax.com
Country: United States
ProdList: 404
Advantage: 50

EJY Tech, Inc.

Tel: --
Fax: --
Country: United States
ProdList: 448
Advantage: 30

Selleck Chemicals LLC

Tel: --
Fax: --
Email: info@selleckchem.com
Country: United States
ProdList: 824
Advantage: 60

Bosgen Chemical Inc.

Tel: --
Fax: --
Email: sale@chemapi.com
Country: United States
ProdList: 609
Advantage: 30

Santa Cruz Biotechnology, Inc.

Tel: --
Fax: --
Email: scbt@scbt.com
Country: United States
ProdList: 3597
Advantage: 60

RnD SciChem, LLC

Tel: --
Fax: --
Email: rndscichem@gmail.com
Country: United States
ProdList: 569
Advantage: 0

Ivy Fine Chemicals

Tel: --
Fax: --
Email: sales@ivychem.com
Country: United States
ProdList: 6493
Advantage: 58

HBCChem Inc.

Tel: --
Fax: --
Email: sales@hbcchem-inc.com
Country: United States
ProdList: 4569
Advantage: 30

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6962
Advantage: 56

AlliChem, LLC

Tel: --
Fax: --
Email: sales@allichemllc.com
Country: United States
ProdList: 6516
Advantage: 60

Medical Isotopes

Tel: --
Fax: --
Email: stohler@medicalisotopes.com
Country: United States
ProdList: 6181
Advantage: 68

ACIC Fine Chemicals Inc.

Tel: --
Fax: --
Email: sales@acic.com
Country: United States
ProdList: 492
Advantage: 48

Waterstone Technology, LLC

Tel: --
Fax: --
Email: sales@waterstonetech.com
Country: United States
ProdList: 6786
Advantage: 30

2A PharmaChem USA

Tel: --
Fax: --
Email: sales@2apharmachem.com
Country: United States
ProdList: 6137
Advantage: 39

Fine Chem Trading LTD

Tel: --
Fax: --
Email: chemfinder@chemfinder.co.uk
Country: United States
ProdList: 1609
Advantage: 64

Hawkins, Inc.

Tel: --
Fax: --
Email: ir@hawkinsinc.com
Country: United States
ProdList: 235
Advantage: 68

Hawkins, Inc.

Tel: --
Fax: --
Email: ir@hawkinsinc.com
Country: United States
ProdList: 212
Advantage: 30

Altan Corporation

Tel: --
Fax: --
Email: OrderingService@AltanBiochemicals.com
Country: United States
ProdList: 1161
Advantage: 30

HONEST JOY HOLDINGS LIMITED

Tel: --
Fax: --
Email: sales@honestjoy.cn
Country: United States
ProdList: 6675
Advantage: 54

Advance Scientific & Chemical

Tel: --
Fax: --
Email: sales@advance-scientific.com
Country: United States
ProdList: 6419
Advantage: 71

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6718
Advantage: 47

APAC Pharmaceutical, LLC

Tel: --
Fax: --
Email: sales@apacpharma.com
Country: United States
ProdList: 6322
Advantage: 38

Wintersun Chemical

Tel: --
Fax: --
Email: purchasing@wintersunchem.com
Country: United States
ProdList: 776
Advantage: 68

NetQem

Tel: --
Fax: --
Email: sales@netqem.us
Country: United States
ProdList: 1641
Advantage: 38

Parchem Trading Ltd.

Tel: --
Fax: --
Email: info@parchem.com
Country: United States
ProdList: 794
Advantage: 76

Less

View Lastest Price from Minoxidil manufacturers

Dorne Chemical Technology co. LTD

Product: Minoxidil 38304-91-5
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 1000kg
Release date: 2024-03-26

Sinoway Industrial co., ltd.

Product: Minoxidil 38304-91-5
Price: US $0.00-0.00/Kg/Bag
Min. Order: 1Kg/Bag
Purity: USP / GMP
Supply Ability: 20 tons
Release date: 2024-06-27

Jinan Million Pharmaceutical Co., Ltd

Product: Minoxidil 38304-91-5
Price: US $1.00/kg
Min. Order: 0.10000000kg
Purity: 99%
Supply Ability: 200KG
Release date: 2024-07-19

38304-91-5, MinoxidilRelated Search:

Zinc oxide Iron oxide Pyrimidine NITRIC OXIDE ETHYLENE OXIDE Iron oxide black Triacetonediamine Magnesium oxide Haloperidol Rutile Finasteride (Diethoxymethyl)diphenylphosphine oxide MINOXIDIL-D10 (PIPERIDINE-D10),MINOXIDIL-D10 NITROUS OXIDE PYRIMITHAMINE 2,4-DIAMINO-6-PIPERIDINOPYRIMIDINE 1-ALLYLPIPERIDINE 2,4-DIAMINO-6-CHLOROPYRIMIDINE/ MINOXIDIL

2,4-diamino-6-piperidinopyrimidine3-n-oxide

4-pyrimidinediamine,6-(1-piperidinyl)-3-oxide

6-amino-1,2-dihydro-1-hydroxy-2-imino-4-piperidinopyrimidine

6-piperidino-2,4-diaminopyrimidine3-oxide

alopexil

2,6-diamino-4-(piperidin-1-yl)pyrimidin-1-ium-1-olate

alostil

lonolox

minossidile

minoximen

pdp

prexidil

regaine

tricoxidil

2,6-diaMino-4-(piperidin-1-yl)-1$l^{5},3-pyriMidin-1-one

Minoxidil (U-10858)

Minoxidil/2,4-DiaMino-6-piperidino-pyriMidine-3-oxide

2,6-Diamino-4-(piperidin-1-yl)pyrimidine 1-oxide

2,3-dihydro-3-hydroxy-2-imino-6-(1-piperidinyl)-4-pyrimidinamine

2,4-diamino-6-piperidinilpirimidina-3-ossido

Minoxidil for system suitability

[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial

ANTI-PDP1 (CENTER) antibody produced in rabbit

PPM2C

Minoxidil, Loniten,Lonolox,Lonoten,Minona

inoxidil

Minoxidil CRS

regain

rogaine

MONOXIDIL

MINOXIDIL

U-10858

2,4-DIAMINO-6-PIPERIDINOPYRIMIDINE 3-OXIDE

6-(1-PIPERIDINYL)-2,4-PYRIMIDINEDIAMINE 3-OXIDE

6-(1-PIPERIDINYL)PYRIMIDINE-2,4-DIAMINE 3-OXIDE

loniten

Minoidil

MINOXIDIL EP, BP, USP

MINOXIDIL K+ CHANNEL ACTIVATOR,

MethylPhosphateEster

2,4-Pyrimidinediamine, 6-(1-piperidinyl)-, 3-oxide

MINOXIDIL,POWDER,USP

TRICLOSAN (IRGASAN)

Minoxidil (Subject To Patent Free)

Minoxidil Base

6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide, 6-(1-Piperidinyl)pyrimidine-2,4-diamine 3-oxide

Minoxidil,6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide, 6-(1-Piperidinyl)pyrimidine-2,4-diamine 3-oxide

Minoxidil (125 mg)

Aalopexil

2,4-diamino-6-piperidino-pyrimidin3-oxide

Minoxidil, 98%, vasodilator agent

minoxidi

LONTEN

Minoxidil&gt

Minoxidil for system suitability CRS

Minoxidil powder/Minoxidil

Minoxidil powder

6-(piperidin-1-yl)pyrimidine-2,4-diamine 3-oxide