3-CHLORO-2-FLUORONITROBENZENE
- Product Name
- 3-CHLORO-2-FLUORONITROBENZENE
- CAS No.
- 2106-49-2
- Chemical Name
- 3-CHLORO-2-FLUORONITROBENZENE
- Synonyms
- 5-Chloro-2-fluoroaniline;1-CHLORO-2-FLUORO-3-NITRO-BENZENE;3-chioro-2-fluoronitrobenzene;2-Fluoro-3-nitrochlorobenzene;3-CHLORO-2-FLUORONITROBENZENE;2-FLUORO-3-CHLORO-NITROBENZENE;3-Chloro-2-fluoro-1-nitrobenzene;3-CHLORO-2-FLUORONITROBENZENE,99%;Benzene, 1-chloro-2-fluoro-3-nitro-;1-Chloro-2-fluoro-3-nitrobenzene,97%
- CBNumber
- CB7384301
- Molecular Formula
- C6H3ClFNO2
- Formula Weight
- 175.54
- MOL File
- 2106-49-2.mol
3-CHLORO-2-FLUORONITROBENZENE Property
- Melting point:
- 36-40
- Boiling point:
- 106 °C(Press: 5 Torr)
- Density
- 1.494±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- form
- Liquid
- color
- Yellow
- Water Solubility
- Soluble in water.
- CAS DataBase Reference
- 2106-49-2(CAS DataBase Reference)
Safety
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 26-36/37/39
- RIDADR
- 2810
- Hazard Note
- Harmful
- HazardClass
- 6.1
- PackingGroup
- Ⅲ
- HS Code
- 2904990090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H331Toxic if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- C585060
- Product name
- 1-Chloro-2-fluoro-3-nitrobenzene
- Packaging
- 2.5g
- Price
- $65
- Updated
- 2021/12/16
- Product number
- C585060
- Product name
- 1-Chloro-2-fluoro-3-nitrobenzene
- Packaging
- 500mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- HCH0021502
- Product name
- 3-CHLORO-2-FLUORO-1-NITROBENZENE
- Purity
- 95.00%
- Packaging
- 25G
- Price
- $1819.13
- Updated
- 2021/12/16
- Product number
- HCH0021502
- Product name
- 3-CHLORO-2-FLUORO-1-NITROBENZENE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $664.13
- Updated
- 2021/12/16
- Product number
- HCH0021502
- Product name
- 3-CHLORO-2-FLUORO-1-NITROBENZENE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1010.63
- Updated
- 2021/12/16
3-CHLORO-2-FLUORONITROBENZENE Chemical Properties,Usage,Production
Uses
1-Chloro-2-fluoro-3-nitrobenzene is used as pharmaceutical intermediates, agrochemical intermediates, intermediates of medicine.
Synthesis
3209-22-1
2106-49-2
General procedure for the synthesis of 3-chloro-2-fluoronitrobenzene from 2,3-dichloronitrobenzene: 500 g (2.08 mol) of 2,3-dichloronitrobenzene was added to a four-necked flask fitted with a stirrer, a thermometer, and a condenser tube, and heated to 140 °C. Subsequently, 112 g (1.93 mol) of potassium fluoride (KF) was added to the reaction system, subjected to a decompression dehydration operation and held at 140-150 °C for 3 hours. After dehydration was completed, the temperature of the reaction system was raised to 140 °C, and then 6.6 g (0.06 mol) of tetramethylammonium chloride was slowly added between 150 and 160 °C. After the addition was completed, the reaction temperature was adjusted to 165±5°C and the reaction was continued for 8 hours. At the end of the reaction, the heating was stopped and the reaction mixture was allowed to cool to room temperature and washed with deionized water. The organic phase was separated and layered by distillation to recover 100 g of unreacted 2,3-dichloronitrobenzene, and finally 240 g of the target product 3-chloro-2-fluoronitrobenzene was obtained, which had a purity of 99.6% and a yield of 87.6%.
References
[1] Patent: CN102249881, 2016, B. Location in patent: Paragraph 0015; 0039-0040
[2] Journal of Medicinal Chemistry, 2001, vol. 44, # 10, p. 1516 - 1529
[3] Journal of the American Chemical Society, 1959, vol. 81, p. 94,95, 97
[4] Patent: US5476976, 1995, A
[5] Patent: US5545768, 1996, A
3-CHLORO-2-FLUORONITROBENZENE Preparation Products And Raw materials
Raw materials
Preparation Products
3-CHLORO-2-FLUORONITROBENZENE Suppliers
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View Lastest Price from 3-CHLORO-2-FLUORONITROBENZENE manufacturers
- Product
- 3-CHLORO-2-FLUORONITROBENZENE 2106-49-2
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100T
- Release date
- 2023-10-31
- Product
- 3-CHLORO-2-FLUORONITROBENZENE 2106-49-2
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
- Product
- 3-CHLORO-2-FLUORONITROBENZENE 2106-49-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2019-06-25