Methyl 4-amino-3-iodobenzoate
- Product Name
- Methyl 4-amino-3-iodobenzoate
- CAS No.
- 19718-49-1
- Chemical Name
- Methyl 4-amino-3-iodobenzoate
- Synonyms
- Methyl 4-amino-3-;2-Iodo-4-carboMethoxyaniline;METHYL 4-AMINO-3-IODOBENZOATE;Methyl 4-amino-3-iodobenzozte;Methyle4-amino-3-iodobenzoate;Methyl 4-aMino-3-iodobenzoate 95% (GC);Benzoic acid, 4-amino-3-iodo-, methyl ester;Methyl 4-
aMino- 3- iodobenzoate;2-iodo-4-(methoxycarbonyl)aniline,methyl 4-amino-3-iodo-benzoate,4-methoxycarbonyl-2-iodoaniline,4-Amino-3-iodo-benzoic acid methyl ester - CBNumber
- CB7390649
- Molecular Formula
- C8H8INO2
- Formula Weight
- 277.06
- MOL File
- 19718-49-1.mol
Methyl 4-amino-3-iodobenzoate Property
- Melting point:
- 86-91 °C (lit.)
- Boiling point:
- 369.6±32.0 °C(Predicted)
- Density
- 1.826±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 0.41±0.10(Predicted)
- form
- Crystalline Powder
- color
- Beige
- InChI
- InChI=1S/C8H8INO2/c1-12-8(11)5-2-3-7(10)6(9)4-5/h2-4H,10H2,1H3
- InChIKey
- MRLVFVTVXSKAMX-UHFFFAOYSA-N
- SMILES
- C(OC)(=O)C1=CC=C(N)C(I)=C1
- CAS DataBase Reference
- 19718-49-1(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 515183
- Product name
- Methyl 4-amino-3-iodobenzoate
- Purity
- 95% (GC)
- Packaging
- 5g
- Price
- $215
- Updated
- 2023/01/07
- Product number
- 515183
- Product name
- Methyl 4-amino-3-iodobenzoate
- Purity
- 95% (GC)
- Packaging
- 25g
- Price
- $474
- Updated
- 2023/01/07
- Product number
- A3659
- Product name
- Methyl 4-Amino-3-iodobenzoate
- Purity
- min. 98.0 %
- Packaging
- 5G
- Price
- $90
- Updated
- 2025/07/31
- Product number
- A3659
- Product name
- Methyl 4-Amino-3-iodobenzoate
- Purity
- min. 98.0 %
- Packaging
- 25G
- Price
- $270
- Updated
- 2025/07/31
- Product number
- M331673
- Product name
- Methyl 4-amino-3-iodobenzoate
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
Methyl 4-amino-3-iodobenzoate Chemical Properties,Usage,Production
Definition
ChEBI: Methyl 4-amino-3-iodobenzoate is a benzoate ester.
Synthesis
619-45-4
19718-49-1
General procedure for the synthesis of methyl 4-amino-3-iodobenzoate from methyl 4-aminobenzoate: dissolve methyl 4-aminobenzoate (5.0 g, 0.033 mol), benzyltrimethylammonium dichloroiodonate (22.1 g, 0.056 mol), and calcium carbonate (5.0 g, 0.050 mol) in a solvent mixture of dichloromethane (200 ml) and methanol (100 g). . The reaction mixture was heated to reflux overnight with stirring. Upon completion of the reaction, the solution was cooled to room temperature, washed with saturated sodium bisulfate solution, and the organic phase was dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford the crude product methyl 4-amino-3-iodobenzoate (9.6 g, quantitative yield), which was used in the subsequent reaction without further purification. The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ 3.75 (s, 3H), 6.09 (s, 2H), 6.75 (d, J = 8.59 Hz, 1H), 7.66 (dd, J = 8.59, 2.02 Hz, 1H), 8.11 (d, J = 2.02 Hz, 1H).
References
[1] Patent: WO2007/38331, 2007, A2. Location in patent: Page/Page column 30-31
[2] Patent: WO2007/103759, 2007, A2. Location in patent: Page/Page column 48
[3] European Journal of Medicinal Chemistry, 2019, p. 234 - 248
[4] European Journal of Organic Chemistry, 2001, # 24, p. 4607 - 4613
[5] Synlett, 2014, vol. 25, # 3, p. 399 - 402
Methyl 4-amino-3-iodobenzoate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyl 4-amino-3-iodobenzoate manufacturers
- Product
- Methyl 4-amino-3-iodobenzoate 19718-49-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-12