ChemicalBook > CAS DataBase List > Sodium Butyrate

Sodium Butyrate

Product Name: Sodium Butyrate
CAS No.: 156-54-7
Chemical Name: Sodium Butyrate
Synonyms: NAB;SODIUM BUTANOATE;SODIUM N-BUTYRATE;BUTYRIC ACID SODIUM SALT;N-BUTYRIC ACID SODIUM SALT;Sodium Butyrate - CAS 156-54-7 - Calbiochem;Natriumbutyrat;butyratesodium;SODIUM BUTYRATE;BUTYRIC ACID NA
CBNumber: CB7391358
Molecular Formula: C4H7NaO2
Formula Weight: 110.09
MOL File: 156-54-7.mol

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Sodium Butyrate Property

Melting point:: 250-253 °C (lit.)
Density: 1.324 g/cm3 (30℃)
storage temp.: Store below +30°C.
solubility: Methanol (Slightly), Water (Slightly)
form: Amorphous Powder
color: White
biological source: synthetic (organic)
Water Solubility: soluble
Sensitive: Hygroscopic
BRN: 3629439
Stability:: Stable. Incompatible with strong acids.
InChI: InChI=1S/C4H8O2.Na/c1-2-3-4(5)6;/h2-3H2,1H3,(H,5,6);/q;+1/p-1
InChIKey: MFBOGIVSZKQAPD-UHFFFAOYSA-M
SMILES: C(CC)C([O-])=O.[Na+]
LogP: 0.777 (est)
CAS DataBase Reference: 156-54-7(CAS DataBase Reference)
NIST Chemistry Reference: Sodium butyrate(156-54-7)
EPA Substance Registry System: Butanoic acid, sodium salt (156-54-7)

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Safety

Hazard Codes: Xn
Risk Statements: 36/37/38-68
Safety Statements: 37/39-26-24/25-36/37
RTECS: ET6400000
F: 3-10
HS Code: 29156000
Hazardous Substances Data: 156-54-7(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.20236
Product name: Sodium butyrate
Purity: for synthesis
Packaging: 250g
Price: $152
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.20236
Product name: Sodium butyrate
Purity: for synthesis
Packaging: 1kg
Price: $533
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.17500
Product name: Sodium butyrate
Purity: special quality
Packaging: 100g
Price: $65.7
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1613600
Product name: Sodium butyrate
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 25mg
Price: $455
Updated: 2025/07/31

Sigma-Aldrich

Product number: 07596
Product name: Sodium butyrate
Purity: certified reference material, TraceCERT
Packaging: 100mg
Price: $131
Updated: 2025/07/31

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Sodium Butyrate Chemical Properties,Usage,Production

Chemical Properties

Sodium butyrate is a white crystalline solid with an unpleasant smell that occurs in butter and animal fat as the glycerol ester. It is the sodium salt of butyric acid. It has various effects on cultured mammalian cells including inhibition of proliferation, induction of differentiation and induction or repression of gene expre.

Uses

Sodium butyrate has been used:
as a component in homogenization and immunoprecipitation buffer for HDAC inhibition in fly embryos and insect s2 cells.
as histone deacetylase inhibitor in breast cancer cell line MDA-MB-231, analysed by cell viability assay and viral replication assay.
to enhance the production of recombinant tissue-plasminogen activator (t-PA) in Chinese hamster ovary (CHO) cells in a bioreactor.

Uses

Sodium Butyrate is an inhibitor of histone deacetylase activity (HDAC) resulting in improvement of physiological disorders such as Duchenne muscular dystropy. In addition it is a possible antitumor agent when used in conjunction with other cytotoxic agents as they have been shown to treat carcinomas.

Definition

ChEBI: Sodium butyrate is an organic sodium salt resulting from the replacement of the proton from the carboxy group of butyric acid by a sodium ion. It has a role as an EC 3.5.1.98 (histone deacetylase) inhibitor and a geroprotector. It contains a butyrate.

benefits

Sodium butyrate, a butyrate, is used in supplements. The benefits of butyrate begin in the gut and extend to a host of other important body systems. It could fuel the gut lining, support healthy gut permeability. promote a healthy inflammation response in the gut, may fight colonic diseases and cancers, promote healthy blood sugar levels, supports normal proliferation of healthy yeast levels, promote cell differentiation, regulate the immune system , combat brain fog and improve sleep, and supports healthy blood pressure levels.

Biological Activity

Histone deacetylase inhibitor. Restores contextual memory in a transgenic mouse model of Alzheimer's disease. Shown to induce pancreatic progenitor formation. Directs the differentiation of mouse embryonic stem cells into hepatocytes when used in combination with the cytokine Activin A.

Biochem/physiol Actions

Sodium butyrate is a short-chain fatty acid that inhibits histone deacetylase (HDAC) in the millimolar range. Decreases Ca2+ release from intracellular stores. Induces apoptosis in several cell lines. Sodium butyrate induces the production of recombinant protein in Chinese hamster ovary (CHO) cells and other human cell lines. Sodium butyrate affects the proteome and gene expression pathways in the cells. It represses cell cycle related genes and modifies the genes involved in cell metabolism and apoptosis.

Synthesis

106-31-0

156-54-7

The general procedure for the synthesis of sodium butyrate from butyric anhydride was as follows: the composition of Example 1b (25 mg, 0.16 mmol) was transferred from an Eppendorf tube to a sample cup and the sample cup was placed in a DNP polarizer. The composition was hyperpolarized using microwave (93.915 GHz) irradiation under a 3.35 T magnetic field and 1.2 K DNP for 75 minutes. Subsequently, the hyperpolarized sample was dissolved in 4 mL of water and NaOH (50 μL, 12 M solution) was added to adjust the pH of the dissolved sample to 12. The solution was transferred directly into a 10 mm NMR tube and placed in a 14.1 T magnetic field, and the time series of 1D 13C-NMR spectra at 5°C were recorded with a total delay of 1 s between pulses.After 10 s, butyric anhydride was quantitatively hydrolyzed (hydrolysis rate up to 95%). The butyric anhydride was well polarized and easily hydrolyzed to produce sodium butyrate.

storage

Room temperature

Purification Methods

Sodium butyrate [156-54-7] M 110.1. Prepare it by neutralising the acid with Na2CO3, and recrystallising it from EtOH. [Beilstein 2 IV 779.]

References

[1] Patent: US9694090, 2017, B2. Location in patent: Page/Page column 26; 27

Sodium Butyrate Preparation Products And Raw materials

Raw materials

Preparation Products

Benzyl butyrate Iopanoic acid Butyric anhydride 2-(4-isobutylphenyl)propionaldehyde 2-(4-isobutylphenyl)propionaldehyde oxime 2-(m-aminobenzyl)butyric acid ALLYL 2-ETHYLBUTYRATE ACETOACETIC ACID N-BUTYL ESTER

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View Lastest Price from Sodium Butyrate manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: Sodium Butyrate 156-54-7
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-29

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

Product: Sodium Butyrate 156-54-7
Price: US $999.00-666.00/ton
Min. Order: 1ton
Purity: 99%
Supply Ability: 5000
Release date: 2024-08-13

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Sodium Butyrate 156-54-7
Price: US $120.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-05-07

156-54-7, Sodium ButyrateRelated Search:

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Sodium Butyrate - CAS 156-54-7 - Calbiochem

SODIUM BUTANOATE

SODIUM BUTYRATE

N-BUTYRIC ACID SODIUM SALT

NAB

N-BUTYRIC ACID, SODIUM

SODIUMBUTYRATE,USP

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Sodium butyrate, 98+%

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Sodium Butyrate (25 mg)

Butyric acid sodiuM salt / sodiuM butanoate

Sodium Butyrate “F” Grade

SODIUM BUTYRATE SPECIAL QUALITY

Sodium butyrate, Butanoic acid, sodium salt

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BUTYRIC ACID NA

SODIUM N-BUTYLATE

SODIUM N-BUTYRATE

SodiumButyrate&gt

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Sodium Butyrate ISO 9001：2015 REACH

Sodium Butyrate CAS 156-54-7

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Sodium Butyrate for cell culture, 99%

Sodium butyrate solution (10mM/L in water)

Sodium butyrate, Histone deacetylase inhibitor

156-54-7

C4H7NaO2

CH3CH22CO2Na

CH3CH2CH2COONa

Organic Building Blocks

Building Blocks

Carbonyl Compounds

Carboxylic Acid Salts

Butyric acid sodium salt

Pharmaceutical Intermediates