tert-Butyl 4'-(bromomethyl)biphenyl-2-carboxylate

Product Name: tert-Butyl 4'-(bromomethyl)biphenyl-2-carboxylate
CAS No.: 114772-40-6
Chemical Name: tert-Butyl 4'-(bromomethyl)biphenyl-2-carboxylate
Synonyms: tert-Butyl 4'-(broMoMethyl)-[1,1'-biphenyl]-2-carboxylate;Tert-Buthyl;Telmisartan EP Impurity H;Telmisatran EP impurity H;Telmisartan Impurity H（EP）;2-Bromo-7-methoxybenzoicacid;2-Boc-4'-(broMoMethyl)biphenyl;Telmisartan Bromo t-Butyl Ester;1,1-Dimethylethyl Esterbiphenyl;2'-(tert-Butoxylcarbonyl)bipheny
CBNumber: CB7395215
Molecular Formula: C18H19BrO2
Formula Weight: 347.25
MOL File: 114772-40-6.mol

More

Less

tert-Butyl 4'-(bromomethyl)biphenyl-2-carboxylate Property

Melting point:: 108-110°C
Boiling point:: 437.0±38.0 °C(Predicted)
Density: 1.278±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Soluble in chloroform, ethyl acetate, and DMSO.
form: Solid
color: White to Pale Yellow
CAS DataBase Reference: 114772-40-6(CAS DataBase Reference)

More

Less

Safety

Risk Statements: 43-53
Safety Statements: 22-24-37-61
HS Code: 29163990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P321Specific treatment (see … on this label).

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

More

Less

N-Bromosuccinimide Price

TRC

Product number: B685385
Product name: 4’-(Bromomethyl)biphenyl-2-carboxylicAcidtert-ButylEster
Packaging: 250mg
Price: $85
Updated: 2021/12/16

TRC

Product number: B685385
Product name: 4’-(Bromomethyl)biphenyl-2-carboxylicAcidtert-ButylEster
Packaging: 5g
Price: $255
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB140353
Product name: tert-Butyl 4'-(bromomethyl)-[1,1'-biphenyl]-2-carboxylate
Packaging: 2g
Price: $51
Updated: 2021/12/16

Matrix Scientific

Product number: 090158
Product name: 2-Boc-4'-(Bromomethyl)biphenyl
Purity: 97%
Packaging: 1g
Price: $76
Updated: 2021/12/16

AK Scientific

Product number: 4128CR
Product name: Tert-butyl4'-(bromomethyl)biphenyl-2-carboxylate
Packaging: 5g
Price: $96
Updated: 2021/12/16

More

Less

tert-Butyl 4'-(bromomethyl)biphenyl-2-carboxylate Chemical Properties,Usage,Production

Chemical Properties

Solid

Uses

1,1-Dimethylethyl Esterbiphenyl is used in the preparation of angiotensin II receptor antagonists.

Uses

tert-Butyl 4'-(bromomethyl)biphenyl-2-carboxylate is a biphenyl derivative used in the preparation of angiotensin II receptor antagonists. T017000

Synthesis

114772-36-0

114772-40-6

The general procedure for the synthesis of tert-butyl 4'-bromomethylbiphenyl-2-carboxylate from tert-butyl 4'-methyl-[1,1'-biphenyl]-2-carboxylate was as follows: in a 1200-liter enameled stirring apparatus, 268.0 kg of tert-butyl 4'-methyl-[1,1'-biphenyl]-2-carboxylate, 157.3 kg of N-bromosuccinimide (DDH), 1.6 kg of azo diisobutyronitrile (AIBN), and 572 liters of methyl acetate. The mixture was heated to 60 °C until the solution became almost colorless. Subsequently, 458 liters of solvent were distilled at atmospheric pressure, followed by the addition of 530 liters of isopropanol, 148 liters of water and 16.4 kg of anhydrous sodium acetate. The resulting mixture was cooled to 15 °C to 25 °C and stirring was continued for 1 hour. The precipitated product was separated by centrifugation, washed with a mixture of 530 liters of acetone and 148 liters of water and finally dried. 295 kg of tert-butyl 4'-bromomethylbiphenyl-2-carboxylate was obtained in a yield of 85% of the theoretical value.

References

[1] Patent: US2002/95042, 2002, A1
[2] Journal of Medicinal Chemistry, 1994, vol. 37, # 7, p. 897 - 906
[3] Patent: US2002/95042, 2002, A1
[4] Patent: US2002/95042, 2002, A1
[5] Patent: WO2013/78237, 2013, A1. Location in patent: Page/Page column 78

tert-Butyl 4'-(bromomethyl)biphenyl-2-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

tert-Butyl 4'-(bromomethyl)biphenyl-2-carboxylate Suppliers

Canada 1 China 167 China Hong Kong 1 Europe 2 Germany 2 India 7 United Kingdom 6 United States 23 Global 209

HBCChem, Inc.

Tel: +1-510-219-6317
Fax: +1-650-486-1361
Email: sales@hbcchem.com
Country: United States
ProdList: 10648
Advantage: 60

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9923
Advantage: 65

AbaChemScene

Tel: 732-484-9848
Fax: 888-484-5008
Email: sales@chemscene.com
Country: United States
ProdList: 3982
Advantage: 60

Standardpharm Co. Ltd.

Tel: 86-714-3992388
Email: overseasales1@yongstandards.com
Country: United States
ProdList: 14332
Advantage: 58

Cato Research Chemicals Inc.

Tel: +86-020-81960175-877 4000-868-328
Email: tianwen.zhan@cato-chem.com
Country: United States
ProdList: 10404
Advantage: 58

Alchem Pharmtech,Inc.

Tel: 8485655694
Email: sales@alchempharmtech.com
Country: United States
ProdList: 63687
Advantage: 58

Aceschem Inc.

Tel: +1-817863-6948 +1-（817）863-6948
Email: sales@aceschem.com
Country: United States
ProdList: 19632
Advantage: 58

Synthonix Inc

Tel: --
Fax: --
Email: info@synthonix.com
Country: United States
ProdList: 6872
Advantage: 58

Small Molecules, Inc.

Tel: --
Fax: --
Email: sales@small-molecules.com
Country: United States
ProdList: 1218
Advantage: 30

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6962
Advantage: 56

Combi-Blocks Inc.

Tel: --
Fax: --
Email: sales@combi-blocks.com
Country: United States
ProdList: 6618
Advantage: 69

Matrix Scientific

Tel: --
Fax: --
Email: sales@matrixscientific.com
Country: United States
ProdList: 6632
Advantage: 80

CacheSyn Inc.

Tel: --
Fax: --
Email: info@cachesyn.com
Country: United States
ProdList: 695
Advantage: 50

American Custom Chemicals Corporation

Tel: --
Fax: --
Email: sales@acccorporation.com
Country: United States
ProdList: 6820
Advantage: 51

Small Molecules, Inc.

Tel: --
Fax: --
Email: sales@small-molecules.com
Country: United States
ProdList: 990
Advantage: 50

Waterstone Technology, LLC

Tel: --
Fax: --
Email: sales@waterstonetech.com
Country: United States
ProdList: 6786
Advantage: 30

2A PharmaChem USA

Tel: --
Fax: --
Email: sales@2apharmachem.com
Country: United States
ProdList: 6137
Advantage: 39

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6718
Advantage: 47

HONEST JOY HOLDINGS LIMITED

Tel: --
Fax: --
Email: sales@honestjoy.cn
Country: United States
ProdList: 6675
Advantage: 54

AK Scientific, Inc.

Tel: --
Fax: --
Email: sales@aksci.com
Country: United States
ProdList: 6347
Advantage: 65

APAC Pharmaceutical, LLC

Tel: --
Fax: --
Email: sales@apacpharma.com
Country: United States
ProdList: 6322
Advantage: 38

BOSCHE SCIENTIFIC, LLC

Tel: --
Fax: --
Email: Sales@BoscheSci.com
Country: United States
ProdList: 6477
Advantage: 55

Beta Pharma, Inc.

Tel: --
Fax: --
Email: sales@betapharma.com
Country: United States
ProdList: 6226
Advantage: 60

More

Less

View Lastest Price from tert-Butyl 4'-(bromomethyl)biphenyl-2-carboxylate manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: tert-Butyl 4'-(bromomethyl)biphenyl-2-carboxylate 114772-40-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-10-25

Qingdao RENAS Polymer Material Co., Ltd.

Product: 4'-Bromomethyl Biphenyl-2-Carboxylic Acid tert-butyl ester 114772-40-6
Price: US $0.00/kg
Min. Order: 20kg
Purity: 99%
Supply Ability: 20 tons
Release date: 2024-11-01

Career Henan Chemical Co

Product: tert-Butyl 4'-(bromomethyl)biphenyl-2-carboxylate 114772-40-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2018-12-25

114772-40-6, tert-Butyl 4'-(bromomethyl)biphenyl-2-carboxylateRelated Search:

FIREMASTER BP-6 4-Bromomethylbenzoic acid tert-Butyl peroxyacetate 2-Bromobiphenyl RESMETHRIN BUTYL OLEATE Cyhalofop-butyl Diphenic acid Biphenyl-4,4'-dicarboxylic acid tert-Butyl acetate Biphenyl Butyl acetate Buprofezin Methyl 4'-bromomethyl biphenyl-2-carboxylate Tris(trimethylsilyl)phosphate tert-Butanol Butyl acrylate Decabromodiphenyl oxide

4'-BROMOMETHYL-BIPHENYL-2-CARBOXYLIC ACID TERT-BUTYL ESTER

4-BROMOMETHYL BIPHENYL-2-CARBOXYLATE-t-BUTYL ESTER

Tert-Butyl-4'-Bromometilbiphenil-2-Carboxilate

tert-Butyl 4'-bromomethyl-2-biphenylcarboxylate

alpha-Bromo-2-(p-tolyl)benzoicacidtert-butylester

Tert-Buthyl

4'-BROMOMETHYLBIPHENYL-2-CARBOXYLIC

Telmisartan Bromo t-Butyl Ester

Telmisartan Impurity 8(Telmisartan EP Impurity H)

2-(4-BroMoMethylphenyl)benzoic Acid tert-Butyl Ester

2'-(tert-Butoxylcarbonyl)bipheny

tert-Butyl 4'-(broMoMethyl)-[1,1'-biphenyl]-2-carboxylate

2-Boc-4'-(broMoMethyl)biphenyl

[1,1'-Biphenyl]-2-carboxylic acid, 4'-(broMoMethyl)-, 1,1-diMethylethyl ester

Telmisartan EP Impurity H

-(bromomethyl)biphenyl-2-carboxylate

TERT-BUTYL 4'-(BROMOMETHYL)BIPHENYL-2-CARBOXYLATE CAS 114772-40-6

Telmisartan EP Impurity H (Telmisartan Bromo t-Butyl Ester)

Telmisatran EP impurity H

Tertiary Butyl-4-(Bromo Methyl )-2-Bi Phenyl Carboxylate

Telmisartan Impurity H（EP）

2-Bromo-7-methoxybenzoicacid

4'-Bromomethyl Biphenyl-2-Carboxyli Acid tert-butyl ester

tert-Butyl 4'-(bromomethyl)biphenyl-2-carboxylate

tert-Butyl 4'-(bromomethyl)-1,1'-biphenyl-2-carboxylate

4’-(Bromomethyl)biphenyl-2-carboxylic Acid tert-Butyl Ester

1,1-dimethylethyl 4'-(bromomethyl)biphenyl-2-carboxylate

1,1-Dimethylethyl Esterbiphenyl

tert-Butyl4-(bromomethyl)biphenyl-2-carboxylate

1,1-Dimethylethyl 4'-(Bromomethyl)biphenyl-2-carboxylate

Telmisartan Imp. H (EP): 1,1-Dimethylethyl 4’-(bromomethyl)biphenyl-2-carboxylate

114772-40-6

C18H19BrO2

Pharmaceutical intermediate

Biphenyl & Diphenyl ether