5-AMINO-1-ETHYLPYRAZOLE

Product Name: 5-AMINO-1-ETHYLPYRAZOLE
CAS No.: 3528-58-3
Chemical Name: 5-AMINO-1-ETHYLPYRAZOLE
Synonyms: AKOS B024267;ART-CHEM-BB B024267;TIMTEC-BB SBB005554;5-Amino-1-ethylpyrazol;1-ethy-pyrazol-5-aMine;2-ethyl-3-pyrazolamine;2-ethylpyrazol-3-amine;2-Amino-1-ethylpyrazole;5-AMINO-1-ETHYLPYRAZOLE;2-Ethyl-3-aMinopyrazole
CBNumber: CB7401714
Molecular Formula: C5H9N3
Formula Weight: 111.15
MOL File: 3528-58-3.mol

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5-AMINO-1-ETHYLPYRAZOLE Property

Melting point:: 52-57 °C (lit.)
Boiling point:: 92-94 °C/0.01 mmHg (lit.)
Density: 1.0671 (rough estimate)
refractive index: 1.5340 (estimate)
Flash point:: >230 °F
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
form: solid
pka: 4.18±0.10(Predicted)
Appearance: Off-white to light yellow Solid
CAS DataBase Reference: 3528-58-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 295760
Product name: 5-Amino-1-ethylpyrazole
Purity: 99%
Packaging: 1g
Price: $83
Updated: 2023/06/20

Sigma-Aldrich

Product number: 295760
Product name: 5-Amino-1-ethylpyrazole
Purity: 99%
Packaging: 5g
Price: $253
Updated: 2022/05/15

TCI Chemical

Product number: A3482
Product name: 1-Ethyl-1H-pyrazol-5-amine
Purity: min. 98.0 %
Packaging: 1G
Price: $89
Updated: 2025/07/31

TCI Chemical

Product number: A3482
Product name: 1-Ethyl-1H-pyrazol-5-amine
Purity: min. 98.0 %
Packaging: 5G
Price: $267
Updated: 2025/07/31

TRC

Product number: B124855
Product name: 1-Ethyl-1H-pyrazol-5-amine
Packaging: 50mg
Price: $60
Updated: 2021/12/16

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5-AMINO-1-ETHYLPYRAZOLE Chemical Properties,Usage,Production

Uses

5-Amino-1-ethylpyrazole is a heterocyclic building block, has been used in the preparation of 1-protected-1H-pyrazolo[3,4-b]pyridines.

Synthesis

75-07-0

107-13-1

3528-58-3

1. Hydrazine hydrate (98.7 g, 1.97 mol) was slowly added dropwise to a solution of 2-acrylonitrile (100 g, 1.88 mol) in tetrahydrofuran (350 ml) at 0-5 °C. 2. The reaction mixture was stirred at room temperature for 3 h. 3. Acetaldehyde (86.9 g, 1.9 mol) was slowly added dropwise to the above mixture, and stirring was continued for 3 h at room temperature. 4. The solvent was removed by distillation under reduced pressure to give a yellow oil. 5. The oil was dissolved in n-butanol (100 ml), followed by addition of a solution of n-butanol (250 ml) containing potassium tert-butanolate (221 g, 1.9 mol). 6. The reaction mixture was gradually heated from room temperature to 120 °C and maintained at this temperature for 3 h. 7. After completion of the reaction, the reaction was cooled to room temperature, and diluted with water (500 ml). 8. ) for dilution. 8. The reaction mixture was extracted with ethyl acetate (3 x 500 ml). 9. The organic layers were combined and dried over anhydrous sodium sulfate, followed by concentration in vacuo. 10. Purification was carried out by column chromatography using silica gel saturated with triethylamine (100-200 mesh), with 20% ethyl acetate in hexane as eluent. 11. The target fractions were collected to afford 1-ethyl-1H-pyrazol-5-amine, Yield: 66.0 g (1.0 g). 12. , Yield: 66.0 g (15% yield), mass spectrum (m/z): (M+H)+ 111.98.

References

[1] Patent: WO2010/46791, 2010, A1. Location in patent: Page/Page column 30-31

5-AMINO-1-ETHYLPYRAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-AMINO-1-ETHYLPYRAZOLE Suppliers

China 84 Germany 2 India 2 Russia 1 Switzerland 1 Ukraine 2 United Kingdom 7 United States 19 Global 118

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View Lastest Price from 5-AMINO-1-ETHYLPYRAZOLE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 5-Amino-1-ethylpyrazol 3528-58-3
Price: US $1.00/Kg
Min. Order: 1Kg
Purity: 98%
Supply Ability: 20T
Release date: 2024-07-19

Career Henan Chemical Co

Product: 5-AMINO-1-ETHYLPYRAZOLE 3528-58-3
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2019-12-25

3528-58-3, 5-AMINO-1-ETHYLPYRAZOLERelated Search:

4,7-DIMETHYLPYRAZOLO(1,5-A)PYRIMIDINE-3-CARBOXYLIC ACID 5-AMINO-4-CYANO-1-(2-HYDROXYETHYL)PYRAZOLE 4,7-DIMETHYLPYRAZOLO[5,1-C][1,2,4]TRIAZINE-3-CARBOXYLIC ACID 5-AMINO-1-ETHYLPYRAZOLE 3-Amino-4-ethylpyrazole 3-AMINO-4-ETHYLPYRAZOLE OXALATE 1-Ethylpyrazole ETHYL 7-METHYL-2-(2-THIENYL)PYRAZOLO[1,5-A]PYRIMIDINE-6-CARBOXYLATE ETHYL 2-METHYL-7-OXO-4,7-DIHYDROPYRAZOLO[1,5-A]PYRIMIDINE-6-CARBOXYLATE 1-(4,7-DIMETHYLPYRAZOLO[5,1-C][1,2,4]TRIAZIN-3-YL)ETHAN-1-ONE 5,7-BIS(TRIFLUOROMETHYL)-3-CYANOPYRAZOLO[1,5-A]PYRIMIDINE 2,3-dihydro-1H-imidazo[1,2-b]pyrazole ETHYL 7-METHYL-2-PHENYLPYRAZOLO[1,5-A]PYRIMIDINE-6-CARBOXYLATE ETHYL 2,7-DIMETHYLPYRAZOLO[1,5-A]PYRIMIDINE-6-CARBOXYLATE 5,7-dimethylpyrazolo[1,5-a]pyrimidine-3-carbonitrile ALLOPURINOL RIBOSIDE 1-[2-(4-CHLOROPHENYL)-7-METHYLPYRAZOLO[1,5-A]PYRIMIDIN-6-YL]ETHAN-1-ONE 1-(2,7-DIMETHYLPYRAZOLO[1,5-A]PYRIMIDIN-6-YL)ETHAN-1-ONE

TIMTEC-BB SBB005554

ART-CHEM-BB B024267

1-ETHYL-1H-PYRAZOL-5-AMINE

2-ETHYL-2H-PYRAZOL-3-YLAMINE

AKOS B024267

5-AMINO-1-ETHYLPYRAZOLE

2-Amino-1-ethylpyrazole

5-Amino-1-ethylpyrazol

5-Amino-1-ethyl-1H-pyrazole

2-Ethyl-3-aMinopyrazole

1H-Pyrazol-5-aMine, 1-ethyl-

1-ethy-pyrazol-5-aMine

1-Ethyl-5-aMinopyrazole

(2-ethylpyrazol-3-yl)amine

2-ethyl-3-pyrazolamine

2-ethylpyrazol-3-amine

1-Ethylpyrazol-5-ylamine

1-Ethyl-1H-pyrazol-5-ylamine

3528-58-3

Pyrazoles

AMINO

Building Blocks

Heterocyclic Building Blocks

Pyrazoles