2,4-Dihydroxy-3-nitropyridine

Uses

Product Name: 2,4-Dihydroxy-3-nitropyridine
CAS No.: 89282-12-2
Chemical Name: 2,4-Dihydroxy-3-nitropyridine
Synonyms: 3-NITRO-2,4-PYRIDINEDIOL;Dihydroxy-3-nitropyridine;4-Dihydroxy-3-nitropyridine;2,4-Dihyroxy-3-nitropyridine;2,4-Hydroxy-3-nitropyridine.;4-Hydroxy-3-nitro-2-pyridone;2,4-Diydroxy-3-nitropyridine;2,4-DIHYDROXY-3-NITROPYRIDINE;4,6-DIHYDROXY-5-NITRO PYRIDINE;2,4-Dihydroxy-3-nitropyridine-1
CBNumber: CB7405853
Molecular Formula: C5H4N2O4
Formula Weight: 156.1
MOL File: 89282-12-2.mol

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2,4-Dihydroxy-3-nitropyridine Property

Melting point:: 265°C (dec.)
Boiling point:: 305.6±42.0 °C(Predicted)
Density: 1.65±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
form: powder to crystal
pka: 4.50±1.00(Predicted)
color: Light yellow to Yellow to Green
BRN: 149558
InChI: InChI=1S/C5H4N2O4/c8-3-1-2-6-5(9)4(3)7(10)11/h1-2H,(H2,6,8,9)
InChIKey: BKYGVGWYPFVKTK-UHFFFAOYSA-N
SMILES: C1(=O)NC=CC(O)=C1[N+]([O-])=O
CAS DataBase Reference: 89282-12-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37/39-37
RIDADR: 3335
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: R436798
Product name: 2,4-DIHYDROXY-3-NITROPYRIDINE
Purity: Aldrich<sup>CPR</sup>
Packaging: 1 unit
Price: $30.7
Updated: 2025/07/31

Sigma-Aldrich

Product number: R436798
Product name: 2,4-DIHYDROXY-3-NITROPYRIDINE
Purity: AldrichCPR
Packaging: 1G
Price: $29.8
Updated: 2024/03/01

TCI Chemical

Product number: D4002
Product name: 2,4-Dihydroxy-3-nitropyridine
Purity: >98.0%(GC)
Packaging: 5g
Price: $45
Updated: 2025/07/31

TCI Chemical

Product number: D4002
Product name: 2,4-Dihydroxy-3-nitropyridine
Purity: >98.0%(GC)
Packaging: 25g
Price: $133
Updated: 2025/07/31

TRC

Product number: B506300
Product name: 3-Nitropyridine-2,4-diol
Packaging: 10g
Price: $75
Updated: 2021/12/16

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2,4-Dihydroxy-3-nitropyridine Chemical Properties,Usage,Production

Uses

2,4-Dihydroxy-3-nitropyridine can be used as a material additive, pharmaceutical chemical, and organic synthesis intermediate. During synthetic transformation, the hydroxyl groups in the structure can be easily converted into halogen atoms due to the influence of the pyridine ring and nitro group. It should be noted that by changing the reaction conditions, one of the two hydroxyl groups can be selectively halogenated, or both can be converted simultaneously. Furthermore, under acidic conditions, a bromine atom can be introduced at the 5-position of the pyridine using liquid bromine.

Chemical Properties

Yellow powder

Reactions

2,4-Dihydroxy-3-nitropyridine could be quickly transformed into 5-bromo-2,4-dihydroxy-3-nitropyridine by the action of a solution of bromine. 3.5 g of 2,4-Dihydroxy-3-nitropyridine were heated with a mixture of 1.15 ml of bromine and 30 ml of acetic acid at 70℃ for 15 minutes. When the reaction mixture was cooled with ice, 3.7 g of 5-bromo-2,4-dihydroxy-3-nitropyridine separated out[1]. Yield: 70 %

Synthesis

626-03-9

89282-12-2

Step 59a. Synthesis of 2,4-dihydroxy-3-nitropyridine (compound 0108): fuming nitric acid (90 mL) was slowly added to a stirring solution of 2,4-dihydroxypyridine (0601) (100 g, 0.9 mol) dissolved in ethyl acetate (300 mL) at 0 °C. After 45 minutes of reaction, the reaction solution was carefully poured into crushed ice and the mixture was cooled in a refrigerator. The resulting precipitate was collected by filtration, washed with cold water and dried to give 4-hydroxy-3-nitropyridin-2(1H)-one (0108) (135 g, 96% yield) as a light yellow solid.LCMS: 157 [M + 1]+; 1H NMR (DMSO-d6) δ 6.05 (d, 1H, J = 7.2 Hz), 7.47 (d, 1H, J = 7.2 Hz), 11.91 (s, 1H), 12.47 (s, 1H).

References

[1] Kolder, C. R. , and H. J. D. Hertog . Migration of halogen atoms in halogeno-derivatives of 2,4-dihydroxypyridine (II). Recueil des Travaux Chimiques des Pays-Bas 72.10(2010):853-858.

2,4-Dihydroxy-3-nitropyridine Preparation Products And Raw materials

Raw materials

NITRIC ACID 2,4-Dihydroxypyridine Nitric acid Sulfuric acid

Preparation Products

2,4-Dichloro-3-nitropyridine

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2,4-Dihydroxy-3-nitropyridine Suppliers

Americas 1 Belgium 1 China 208 Europe 1 France 3 Germany 7 India 16 Japan 2 Switzerland 2 The Netherlands 3 United Kingdom 11 United States 40 Global 295

J & K SCIENTIFIC LTD.

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View Lastest Price from 2,4-Dihydroxy-3-nitropyridine manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 2,4-Dihydroxy-3-nitropyridine 89282-12-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-27

Dideu Industries Group Limited

Product: 2,4-Dihydroxy-3-nitropyridine 89282-12-2
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-09-24

Career Henan Chemical Co

Product: 2,4-Dihydroxy-3-nitropyridine 89282-12-2
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: Customized
Release date: 2018-12-22

89282-12-2, 2,4-Dihydroxy-3-nitropyridineRelated Search:

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4,6-DIHYDROXY-5-NITRO PYRIDINE

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2(1H)-Pyridinone, 4-hydroxy-3-nitro-

2,4-Dihydroxy-3-nitropyridine ,99%

4-Dihydroxy-3-nitropyridine

3-Nitro-2,4-pyridinediol 4-Hydroxy-3-nitro-2-pyridone 4-Hydroxy-3-nitro-2(1H)-pyridinone

2,4-Dihyroxy-3-nitropyridine

2-hydroxy-3-nitro-1H-pyridin-4-one

Dihydroxy-3-nitropyridine

4-hydroxy-3-nitro-2(1H)-pyridone

2,4-Diydroxy-3-nitropyridine

2,4-Dihydroxy-3-nitropyridine-1

2,4-Dihydroxy-3-nitropyridine&gt

4-Hydroxy-3-nitro-2(1H)-pyridinone

2,4-Dihydroxy-3-nitropyridine ISO 9001：2015 REACH

4-Hydroxy-3-nitropyridin-2(1H)-one

4-hydroxy-3-nitro-1H-pyridin-2-one

89282-12-2

Pyridine Series

Heterocycle-Pyridine series

Pyridine

Heterocycles