2-Phenylquinoline

Product Name: 2-Phenylquinoline
CAS No.: 612-96-4
Chemical Name: 2-Phenylquinoline
Synonyms: 830g;2-Phenylquinoline;a-Phenylquinoline;Phenylquinoline,99%;2-Phenylquinoline>Phenylquinoline, 99%;Quinoline, 2-phenyl-;2-Phenylquinoline 99%;alpha-Phenylquinoline;2-Phenylquinoline, 99+%
CBNumber: CB7408748
Molecular Formula: C15H11N
Formula Weight: 205.25
MOL File: 612-96-4.mol

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2-Phenylquinoline Property

Melting point:: 84-85 °C (lit.)
Boiling point:: 363 °C
Density: 1.1155 (rough estimate)
refractive index: 1.6550 (estimate)
storage temp.: Sealed in dry,Room Temperature
pka: 4.52±0.10(Predicted)
form: Crystalline Powder
color: White to light yellow
Water Solubility: SLIGHTLY SOLUBLE
λmax: 258nm(lit.)
InChI: 1S/C15H11N/c1-2-6-12(7-3-1)15-11-10-13-8-4-5-9-14(13)16-15/h1-11H
InChIKey: FSEXLNMNADBYJU-UHFFFAOYSA-N
SMILES: c1ccc(cc1)-c2ccc3ccccc3n2
CAS DataBase Reference: 612-96-4(CAS DataBase Reference)
NIST Chemistry Reference: Quinoline, 2-phenyl-(612-96-4)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39
WGK Germany: 3
HS Code: 29334900
Storage Class: 11 - Combustible Solids
Hazard Classifications: Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 299650
Product name: 2-Phenylquinoline
Purity: 99%
Packaging: 1g
Price: $83.4
Updated: 2025/07/31

Sigma-Aldrich

Product number: 299650
Product name: 2-Phenylquinoline
Purity: 99%
Packaging: 5g
Price: $396
Updated: 2025/07/31

TCI Chemical

Product number: P2057
Product name: 2-Phenylquinoline
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $61
Updated: 2025/07/31

TCI Chemical

Product number: P2057
Product name: 2-Phenylquinoline
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $206
Updated: 2025/07/31

TRC

Product number: P321030
Product name: 2-Phenylquinoline
Packaging: 50mg
Price: $60
Updated: 2021/12/16

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2-Phenylquinoline Chemical Properties,Usage,Production

Description

2-Phenylquinoline is the major quinoline alkaloid of Galipea iongiflora, a Bolivian plant used as treatment for cutaneous leishmaniasis. Antinociceptive properties of 2-phenylquinoline isolated from the bark of Galipea iongiflora against different models of pain in mice were evaluated.

Chemical Properties

white to light yellow crystalline powder

Uses

2-Phenylquinoline was used in quantitative structure-activity relationship (QSAR) analyses of estrogen receptor β-selective ligands.

Preparation

Synthesis of 2-phenylquinoline: Quinoline (1.0 g, 7.742 mmol) and phenyl lithium (2.30 mL, 2 M, 23.22 mmol) were reacted according to general procedure. Purification of the residue by silica gel column chromatography (EtOAc:MeOH:Et3N; 10-30:1:1 or PhMe:MeOH:Et3N; 10:1:1) gave 2-phenylquinoline (0.66 g, 42%) as an orange solid.
Aniline (0.140 g, 1.50 mmol) and cinnamaldehyde (0.132 g, 1.00 mmol) were dissolved in toluene in a reaction vial equipped with a magnetic stirrer bar, followed by the addition of K10 (0.50 g). The reaction mixture was heated at a temperature of 110 ?C for 3 hours. After completion of the reaction, the crude product was purified by column chromatography over silica gel eluting with a mixture of Hexane : Ethyl acetate (20:1) to produce 2-Phenylquinoline as a yellow solid (0.044 g, 21%); (m.p. 82-84 ?C) (lit. 84-85 °C); Rf 0.67 (20:1 hexane:ethyl acetate);
1H NMR (400 MHz, CDCl3) δH 7.46-7.51 (1H, m, H-4’), 7.53-7.56 (3H, m, H-6, 3’, 5’), 7.73- 7.77 (1H, m, H-7), 7.85 (1H, d, J = 8.31 Hz, H-5), 7.88-7.91 (1H, d, J = 8.31 Hz, H-3), 8.18- 8.27 (4H, m, H-4, 8, 2’, 6’)
13C NMR(400 MHz, CDCl3) δC 119.2 (C-3), 126.7 (C-6), 127.2 (C-4a), 127.5 (C-2’, 6’), 127.9 (C-5), 128.4 (C-3’, 5’), 128.7 (C-4’), 128.9 (C-7, 8), 129.8 (C-4), 130.3 (C-1’), 137.9 (C-8a), 157.2 (C-2)

Synthesis Reference(s)

Synthetic Communications, 23, p. 1959, 1993 DOI: 10.1080/00397919308009854
Chemical and Pharmaceutical Bulletin, 26, p. 3485, 1978 DOI: 10.1248/cpb.26.3485
Journal of the American Chemical Society, 71, p. 2327, 1949 DOI: 10.1021/ja01175a017

2-Phenylquinoline Preparation Products And Raw materials

Raw materials

Phenylmagnesium bromide Quinoline Phenyllithium Bromobenzene 1,4-Dioxane

Preparation Products

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2-Phenylquinoline Suppliers

Belgium 1 China 162 Germany 3 India 4 Japan 3 Switzerland 1 United Kingdom 5 United States 18 Global 197

J & K SCIENTIFIC LTD.

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INTATRADE GmbH

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Energy Chemical

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JinYan Chemicals(ShangHai) Co.,Ltd.

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Nanjing Habo Medical Technology Co., Ltd.

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View Lastest Price from 2-Phenylquinoline manufacturers

Henan Fengda Chemical Co., Ltd

Product: 2-Phenylquinoline 612-96-4
Price: US $188.00-1.00/KG
Min. Order: 1KG
Purity: 99%, 99.5% Sublimated
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-01-05

Career Henan Chemical Co

Product: 2-Phenylquinoline 612-96-4
Price: US $8.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10TON
Release date: 2018-12-18

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2-Phenylquinoline ISO 9001：2015 REACH

612-96-4

C6H5C9H6N

C15H11N

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