2-Phenylquinoline
- Product Name
- 2-Phenylquinoline
- CAS No.
- 612-96-4
- Chemical Name
- 2-Phenylquinoline
- Synonyms
- 830g;2-Phenylquinoline;a-Phenylquinoline;Phenylquinoline,99%;2-Phenylquinoline>Phenylquinoline, 99%;Quinoline, 2-phenyl-;2-Phenylquinoline 99%;alpha-Phenylquinoline;2-Phenylquinoline, 99+%
- CBNumber
- CB7408748
- Molecular Formula
- C15H11N
- Formula Weight
- 205.25
- MOL File
- 612-96-4.mol
2-Phenylquinoline Property
- Melting point:
- 84-85 °C (lit.)
- Boiling point:
- 363 °C
- Density
- 1.1155 (rough estimate)
- refractive index
- 1.6550 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 4.52±0.10(Predicted)
- form
- Crystalline Powder
- color
- White to light yellow
- Water Solubility
- SLIGHTLY SOLUBLE
- λmax
- 258nm(lit.)
- CAS DataBase Reference
- 612-96-4(CAS DataBase Reference)
- NIST Chemistry Reference
- Quinoline, 2-phenyl-(612-96-4)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 299650
- Product name
- 2-Phenylquinoline
- Purity
- 99%
- Packaging
- 1g
- Price
- $80.9
- Updated
- 2024/03/01
- Product number
- 299650
- Product name
- 2-Phenylquinoline
- Purity
- 99%
- Packaging
- 5g
- Price
- $384
- Updated
- 2024/03/01
- Product number
- P2057
- Product name
- 2-Phenylquinoline
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $66
- Updated
- 2024/03/01
- Product number
- P2057
- Product name
- 2-Phenylquinoline
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $223
- Updated
- 2024/03/01
- Product number
- H31920
- Product name
- 2-Phenylquinoline, 99+%
- Packaging
- 1g
- Price
- $70.65
- Updated
- 2024/03/01
2-Phenylquinoline Chemical Properties,Usage,Production
Description
2-Phenylquinoline is the major quinoline alkaloid of Galipea iongiflora, a Bolivian plant used as treatment for cutaneous leishmaniasis. Antinociceptive properties of 2-phenylquinoline isolated from the bark of Galipea iongiflora against different models of pain in mice were evaluated.
Chemical Properties
white to light yellow crystalline powder
Uses
2-Phenylquinoline was used in quantitative structure-activity relationship (QSAR) analyses of estrogen receptor β-selective ligands.
Preparation
Synthesis of 2-phenylquinoline: Quinoline (1.0 g, 7.742 mmol) and phenyl lithium (2.30 mL, 2 M, 23.22 mmol) were reacted according to general procedure. Purification of the residue by silica gel column chromatography (EtOAc:MeOH:Et3N; 10-30:1:1 or PhMe:MeOH:Et3N; 10:1:1) gave 2-phenylquinoline (0.66 g, 42%) as an orange solid.
Aniline (0.140 g, 1.50 mmol) and cinnamaldehyde (0.132 g, 1.00 mmol) were dissolved in toluene in a reaction vial equipped with a magnetic stirrer bar, followed by the addition of K10 (0.50 g). The reaction mixture was heated at a temperature of 110 ?C for 3 hours. After completion of the reaction, the crude product was purified by column chromatography over silica gel eluting with a mixture of Hexane : Ethyl acetate (20:1) to produce 2-Phenylquinoline as a yellow solid (0.044 g, 21%); (m.p. 82-84 ?C) (lit. 84-85 °C); Rf 0.67 (20:1 hexane:ethyl acetate);
1H NMR (400 MHz, CDCl3) δH 7.46-7.51 (1H, m, H-4’), 7.53-7.56 (3H, m, H-6, 3’, 5’), 7.73- 7.77 (1H, m, H-7), 7.85 (1H, d, J = 8.31 Hz, H-5), 7.88-7.91 (1H, d, J = 8.31 Hz, H-3), 8.18- 8.27 (4H, m, H-4, 8, 2’, 6’)
13C NMR(400 MHz, CDCl3) δC 119.2 (C-3), 126.7 (C-6), 127.2 (C-4a), 127.5 (C-2’, 6’), 127.9 (C-5), 128.4 (C-3’, 5’), 128.7 (C-4’), 128.9 (C-7, 8), 129.8 (C-4), 130.3 (C-1’), 137.9 (C-8a), 157.2 (C-2)
Synthesis Reference(s)
Synthetic Communications, 23, p. 1959, 1993 DOI: 10.1080/00397919308009854
Chemical and Pharmaceutical Bulletin, 26, p. 3485, 1978 DOI: 10.1248/cpb.26.3485
Journal of the American Chemical Society, 71, p. 2327, 1949 DOI: 10.1021/ja01175a017
2-Phenylquinoline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Phenylquinoline manufacturers
- Product
- 2-Phenylquinoline 612-96-4
- Price
- US $188.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%, 99.5% Sublimated
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-01-05
- Product
- 2-Phenylquinoline 612-96-4
- Price
- US $8.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10TON
- Release date
- 2018-12-18