2-Phenylquinoline

Product Name: 2-Phenylquinoline
CAS No.: 612-96-4
Chemical Name: 2-Phenylquinoline
Synonyms: 830g;2-Phenylquinoline;a-Phenylquinoline;Phenylquinoline,99%;2-Phenylquinoline>Phenylquinoline, 99%;Quinoline, 2-phenyl-;2-Phenylquinoline 99%;alpha-Phenylquinoline;2-Phenylquinoline, 99+%
CBNumber: CB7408748
Molecular Formula: C15H11N
Formula Weight: 205.25
MOL File: 612-96-4.mol

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2-Phenylquinoline Property

Melting point:: 84-85 °C (lit.)
Boiling point:: 363 °C
Density: 1.1155 (rough estimate)
refractive index: 1.6550 (estimate)
storage temp.: Sealed in dry,Room Temperature
pka: 4.52±0.10(Predicted)
form: Crystalline Powder
color: White to light yellow
Water Solubility: SLIGHTLY SOLUBLE
λmax: 258nm(lit.)
CAS DataBase Reference: 612-96-4(CAS DataBase Reference)
NIST Chemistry Reference: Quinoline, 2-phenyl-(612-96-4)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39
WGK Germany: 3
HS Code: 29334900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 299650
Product name: 2-Phenylquinoline
Purity: 99%
Packaging: 1g
Price: $80.9
Updated: 2024/03/01

Sigma-Aldrich

Product number: 299650
Product name: 2-Phenylquinoline
Purity: 99%
Packaging: 5g
Price: $384
Updated: 2024/03/01

TCI Chemical

Product number: P2057
Product name: 2-Phenylquinoline
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $66
Updated: 2024/03/01

TCI Chemical

Product number: P2057
Product name: 2-Phenylquinoline
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $223
Updated: 2024/03/01

Alfa Aesar

Product number: H31920
Product name: 2-Phenylquinoline, 99+%
Packaging: 1g
Price: $70.65
Updated: 2024/03/01

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2-Phenylquinoline Chemical Properties,Usage,Production

Description

2-Phenylquinoline is the major quinoline alkaloid of Galipea iongiflora, a Bolivian plant used as treatment for cutaneous leishmaniasis. Antinociceptive properties of 2-phenylquinoline isolated from the bark of Galipea iongiflora against different models of pain in mice were evaluated.

Chemical Properties

white to light yellow crystalline powder

Uses

2-Phenylquinoline was used in quantitative structure-activity relationship (QSAR) analyses of estrogen receptor β-selective ligands.

Preparation

Synthesis of 2-phenylquinoline: Quinoline (1.0 g, 7.742 mmol) and phenyl lithium (2.30 mL, 2 M, 23.22 mmol) were reacted according to general procedure. Purification of the residue by silica gel column chromatography (EtOAc:MeOH:Et3N; 10-30:1:1 or PhMe:MeOH:Et3N; 10:1:1) gave 2-phenylquinoline (0.66 g, 42%) as an orange solid.
Aniline (0.140 g, 1.50 mmol) and cinnamaldehyde (0.132 g, 1.00 mmol) were dissolved in toluene in a reaction vial equipped with a magnetic stirrer bar, followed by the addition of K10 (0.50 g). The reaction mixture was heated at a temperature of 110 ?C for 3 hours. After completion of the reaction, the crude product was purified by column chromatography over silica gel eluting with a mixture of Hexane : Ethyl acetate (20:1) to produce 2-Phenylquinoline as a yellow solid (0.044 g, 21%); (m.p. 82-84 ?C) (lit. 84-85 °C); Rf 0.67 (20:1 hexane:ethyl acetate);
1H NMR (400 MHz, CDCl3) δH 7.46-7.51 (1H, m, H-4’), 7.53-7.56 (3H, m, H-6, 3’, 5’), 7.73- 7.77 (1H, m, H-7), 7.85 (1H, d, J = 8.31 Hz, H-5), 7.88-7.91 (1H, d, J = 8.31 Hz, H-3), 8.18- 8.27 (4H, m, H-4, 8, 2’, 6’)
13C NMR(400 MHz, CDCl3) δC 119.2 (C-3), 126.7 (C-6), 127.2 (C-4a), 127.5 (C-2’, 6’), 127.9 (C-5), 128.4 (C-3’, 5’), 128.7 (C-4’), 128.9 (C-7, 8), 129.8 (C-4), 130.3 (C-1’), 137.9 (C-8a), 157.2 (C-2)

Synthesis Reference(s)

Synthetic Communications, 23, p. 1959, 1993 DOI: 10.1080/00397919308009854
Chemical and Pharmaceutical Bulletin, 26, p. 3485, 1978 DOI: 10.1248/cpb.26.3485
Journal of the American Chemical Society, 71, p. 2327, 1949 DOI: 10.1021/ja01175a017

2-Phenylquinoline Preparation Products And Raw materials

Raw materials

PHENYLMAGNESIUM BROMIDE Quinoline Phenyllithium Bromobenzene 1,4-Dioxane

Preparation Products

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2-Phenylquinoline Suppliers

Belgium 1 China 160 Germany 3 India 4 Japan 3 Switzerland 1 United Kingdom 5 United States 18 Global 195

Nanjing Asfam Pharmaceutical Technology Co., Ltd.

Tel: 025-58867862 18751812725
Fax: 02558867862
Email: sales@ace-pharm.com
Country: China
ProdList: 1994
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J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
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Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 021-61259108 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

INTATRADE GmbH

Tel: +49 3493/605464
Fax: +49 3493/605470
Email: sales@intatrade.de
Country: Germany
ProdList: 3572
Advantage: 66

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
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TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
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Email: Sales-CN@TCIchemicals.com
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ProdList: 24529
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Energy Chemical

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Email: sales8178@energy-chemical.com
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Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
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ProdList: 18207
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JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
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ProdList: 9976
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Nanjing Habo Medical Technology Co., Ltd.

Tel: 025-85760892 13376090521
Fax: 025-85766769
Email: sales@habotech.com
Country: China
ProdList: 979
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View Lastest Price from 2-Phenylquinoline manufacturers

Henan Fengda Chemical Co., Ltd

Product: 2-Phenylquinoline 612-96-4
Price: US $188.00-1.00/KG
Min. Order: 1KG
Purity: 99%, 99.5% Sublimated
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-01-05

Career Henan Chemical Co

Product: 2-Phenylquinoline 612-96-4
Price: US $8.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10TON
Release date: 2018-12-18

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2-Phenylquinoline ISO 9001：2015 REACH

612-96-4

C6H5C9H6N

C15H11N

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