2-(2-Aminothiazole-4-yl)-2-hydroxyiminoacetic acid

Product Name: 2-(2-Aminothiazole-4-yl)-2-hydroxyiminoacetic acid
CAS No.: 66338-96-3
Chemical Name: 2-(2-Aminothiazole-4-yl)-2-hydroxyiminoacetic acid
Synonyms: HATA;ATHAA;-2-(hydroxyimino);4-Thiazylacetic acid;Ceftazidime Impurity 21;(Z)-2-Hydroxyimino-2-(2-aminot;(2-AMINOTHIAZOL-4-YL)HYDROXYIMINO ACETIC ACID;2-(2-Amino-4-thiazolyl)-2-hydroxyiminoaceticacid;2-Amino-alpha-(hydroxyimino)-4-thiazoleaceticacid;2-(2-aminothiazole-4-yl)-z-hydroxyiminoaceticacid
CBNumber: CB7418271
Molecular Formula: C5H5N3O3S
Formula Weight: 187.18
MOL File: 66338-96-3.mol

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2-(2-Aminothiazole-4-yl)-2-hydroxyiminoacetic acid Property

Melting point:: 190-192°C
Boiling point:: 539.4±42.0 °C(Predicted)
Density: 1.92±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility: DMSO (Slightly, Heated)
form: Solid
pka: 10.37±0.70(Predicted)
color: Pale Beige
CAS DataBase Reference: 66338-96-3(CAS DataBase Reference)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: A630280
Product name: (Z)-2-(2-Aminothiazol-4-yl)-2-(hydroxyimino)aceticAcid
Packaging: 1g
Price: $45
Updated: 2021/12/16

Matrix Scientific

Product number: 118898
Product name: (Z)-2-(2-Aminothiazol-4-yl)-2-(hydroxyimino)acetic acid
Purity: 95+%
Packaging: 1g
Price: $36
Updated: 2021/12/16

Matrix Scientific

Product number: 118898
Product name: (Z)-2-(2-Aminothiazol-4-yl)-2-(hydroxyimino)acetic acid
Purity: 95+%
Packaging: 5g
Price: $108
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA140117
Product name: (Z)-2-(2-Aminothiazol-4-yl)-2-(hydroxyimino)acetic acid
Packaging: 10g
Price: $110
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: APN0000031
Product name: (Z)-2-HYDROXYIMINO-2-(2-AMINOTHIAZOL-4-YL)ACETIC ACID
Purity: 95.00%
Packaging: 1G
Price: $130.2
Updated: 2021/12/16

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2-(2-Aminothiazole-4-yl)-2-hydroxyiminoacetic acid Chemical Properties,Usage,Production

Uses

(Z)-2-(2-Aminothiazol-4-yl)-2-(hydroxyimino)acetic Acid?can be used to synthesize cephalosporin derivatives and β-lactam antibiotics.

Synthesis

68401-22-9

66338-96-3

GENERAL METHOD: NaOH (2.4 g, 0.06 mol) was dissolved in water (100 mL) and stirred under cooling in an ice bath. To this solution was added ethyl 2-(2-aminothiazol-4-yl)-2-(trans)-hydroxyiminoacetate or ethyl 2-(2-aminothiazol-4-yl)-2-(cis)-hydroxyiminoacetate (10.76 g, 0.05 mol). The reaction mixture was stirred at 15-20°C for 2-3 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The residual solid was dissolved in water (100 mL), decolorized by the addition of Norit (1.0 g) and filtered. Glacial acetic acid was slowly added dropwise to the filtrate under stirring until the pH reached neutral. The resulting precipitate was collected by filtration, washed with water and finally the product was purified by two ethanol recrystallizations.

References

[1] Polyhedron, 2015, vol. 85, p. 208 - 220

2-(2-Aminothiazole-4-yl)-2-hydroxyiminoacetic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-(2-Aminothiazole-4-yl)-2-hydroxyiminoacetic acid manufacturers

Career Henan Chemical Co

Product: 2-(2-Aminothiazole-4-yl)-2-hydroxyiminoacetic acid 66338-96-3
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2019-12-31

66338-96-3, 2-(2-Aminothiazole-4-yl)-2-hydroxyiminoacetic acidRelated Search:

2-Aminothiazole-4-acetic acid Molasses 2-(2-Aminothiazol-4-yl)glyoxylic acid Cefotaxime sodium Cefotaxime 2-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid Glycine Ethyl 2-(2-aminothiazole-4-yl)-2-hydroxyiminoacetate 2-(TRITYLAMINO)-ALPHA-(METHOXYIMINO)-4-THIAZOLEACETIC ACID HYDROCHLORIDE (Z)-2-(2-Aminothiazol-4-yl)-2-(1-carboxy-1-methyl)ethoxyiminoacetic acid (Z)-2-(2-Aminothiazol-4-yl)-2-(tert-butoxycarbonylmethoxyimino)acetic acid (Z)-2-(5-AMINO-1,2,4-THIADIAZOL-3-YL)-2-METHOXYIMINO ACETIC ACID Ethyl 2-(2-aminothiazole-4-yl)-2-(1-tert-butoxycarbonyl-1-methylethoxyimino)acetate Ethyl 2-(2-aminothiazol-4-yl)-2-methoxyiminoacetate 2-(2-Formamidothiazole-4-yl)-2-methoxyimino acetic acid (Z)-2-(Methoxycarbonylmethoxyimino)-2-(2-aminothiazol-4-yl)acetic acid 2-Aminothiazole (Z)-[2-(Chloroacetamido)thiazole-4-yl]methoxyiminoacetic acid

-2-(hydroxyimino)

2-(2-Amino-4-thiazolyl)-2-hydroxyiminoaceticacid

2-(2-aminothiazole-4-yl)-z-hydroxyiminoaceticacid

2-Amino-alpha-(hydroxyimino)-4-thiazoleaceticacid

2-(2-AMINOTHIAZOLE-4-YL)-2-HYDROXYIMINOACETIC ACID

(2-AMINOTHIAZOL-4-YL)HYDROXYIMINO ACETIC ACID

(Z)-2-HYDROXYIMINO-2-(2-AMINOTHIAZOL-4-YL)ACETIC ACID

(Z)-2-HYDROXYIMINO-2-(2-AMINOTHIAZOLE-4-YL)ACETIC ACID

(Z)-2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetic acid

2-(2-Aminothiazole-4-yl)-2-hydroxyiminoacetic acid(HATA)

(Z)-2-Hydroxyimino-2-(2-aminothiazol-4-yl)Acetic acid anhydrous

ATHA ( Z )-2-(2-Aminothiazol-4-yl)-2-hydroxyiminoacetic acid

(Z)-2-Hydroxyimino-2-(2-aminot

(Z)-2-HYDROXYIMINO-2-(2-AMINOTHIAZOL-4-YL) ACETIC ACID/HATA

HATA

ATHAA

(Z)-2-(2-Amino-4-thiazolyl)-2-hydroxyiminoacetic acid

(Z)-2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetic Acid (HATA)

2-(2-Aminothiazole-4-yl)-2-hydroxyiminoaceticacid,97%

(Z)-2-(2-Aminothiazole-4-yl)-2-hydroxyiminoacetic acid

2-(2-Aminothiazole-4-yl)-2-hydroxyiminoacetic acid ,98%

2-(2-aMino-1,3-thiazol-4-yl)-2-(N-hydroxyiMino)acetic acid

Ceftazidime Impurity 21

4-Thiazoleacetic acid, 2-amino-α-(hydroxyimino)-, (αZ)-

4-Thiazoleacetic acid, 2-amino-a-(hydroxyimino)-, (aZ)-

4-Thiazylacetic acid

(Z)-2-(2-Aminothiazol-4-yl)-2-(hydroxyimino)acetic acid - [A92221]

66338-96-3

C5H5N3O3S

Cephalosporins