2-Amino-4,5-dimethoxybenzoic acid
- Product Name
- 2-Amino-4,5-dimethoxybenzoic acid
- CAS No.
- 5653-40-7
- Chemical Name
- 2-Amino-4,5-dimethoxybenzoic acid
- Synonyms
- LR-79;TIMTEC-BB SBB007800;RARECHEM AL BO 1315;6-AMINOVERATRIC ACID;LABOTEST-BB LT00080709;4,5-DimethoxyanthraniL;5-diMethoxybenzoic acid;4,5-Dimethoxyanthranilic;2-Amino-4,5-dimethoxybenzoic;4,5-Dimethoxyanthanilic acid
- CBNumber
- CB7420531
- Molecular Formula
- C9H11NO4
- Formula Weight
- 197.19
- MOL File
- 5653-40-7.mol
2-Amino-4,5-dimethoxybenzoic acid Property
- Melting point:
- 169-173 °C (dec.) (lit.)
- Boiling point:
- 334.28°C (rough estimate)
- Density
- 1.3075 (rough estimate)
- refractive index
- 1.5270 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Acetontrile (Slightly), DMSO (Slightly), Methanol (Slightly)
- form
- Crystalline Powder
- pka
- 2.35±0.10(Predicted)
- color
- White, beige, or gray to brown
- Water Solubility
- Soluble in Methanol and Water
- BRN
- 782814
- Stability:
- May be Sensitive To Air Oxidation, Light Sensitive
- InChI
- InChI=1S/C9H11NO4/c1-13-7-3-5(9(11)12)6(10)4-8(7)14-2/h3-4H,10H2,1-2H3,(H,11,12)
- InChIKey
- HJVAVGOPTDJYOJ-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C1=CC(OC)=C(OC)C=C1N
- CAS DataBase Reference
- 5653-40-7(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 37/39-26-36
- WGK Germany
- 3
- HS Code
- 29225090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 252042
- Product name
- 2-Amino-4,5-dimethoxybenzoic acid
- Purity
- 98%
- Packaging
- 5g
- Price
- $35.42
- Updated
- 2025/07/31
- Product number
- D2013
- Product name
- 4,5-Dimethoxyanthranilic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 10g
- Price
- $41
- Updated
- 2025/07/31
- Product number
- A604940
- Product name
- 2-Amino-4,5-dimethoxybenzoic acid
- Packaging
- 50g
- Price
- $110
- Updated
- 2021/12/16
- Product number
- FA17551
- Product name
- 2-Amino-4,5-dimethoxybenzoic acid
- Packaging
- 100g
- Price
- $120
- Updated
- 2021/12/16
- Product number
- 4657-1-43
- Product name
- 2-Amino-4,5-dimethoxybenzoic acid
- Packaging
- 100g
- Price
- $164
- Updated
- 2021/12/16
2-Amino-4,5-dimethoxybenzoic acid Chemical Properties,Usage,Production
Chemical Properties
Brown Solid
Uses
2-Amino-4,5-dimethoxybenzoic acid is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
4998-07-6
5653-40-7
General procedure for the synthesis of 2-amino-4,5-dimethoxybenzoic acid from 6-nitroveratric acid: first, 48.13 g (0.729 mol) of KOH pellets (85% purity) were dissolved in 250 ml of ice water. Subsequently, 50 g (0.207 mol) of methyl-4,5-dimethoxy-2-nitrobenzoate (1) was added to this clarified solution, and the resulting green suspension was heated to 70 °C. During heating, the color of the solution shifted to dark red. The progress of the reaction was monitored by HPLC and upon completion of the reaction, the solution was cooled to room temperature and the pH was adjusted to 6.6 with 34.6 g (0.570 mol) of glacial acetic acid.The obtained red suspension was hydrogenated at 50 °C and 3.5 bar pressure using 1 g of 10% Pd/C catalyst until the reaction was terminated. Upon completion of hydrogenation, the solution was filtered and the pH was adjusted to 5.1 with 31.82 g (0.525 mol) of glacial acetic acid under the protection of an inert gas.The light green suspension formed was stirred at room temperature for 30 min, followed by cooling to 5 °C and continued stirring for 30 min. The product (2) was obtained by filtration, washed in two batches with a total of 250 ml of ice water and finally dried in a vacuum oven at 55°C for 12 hrs. This process yielded 35.18 g (0.173 mol, 83% yield) of light gray crystalline product.
References
[1] Organic and Biomolecular Chemistry, 2018, vol. 16, # 28, p. 5119 - 5135
[2] Chemistry - An Asian Journal, 2017, vol. 12, # 7, p. 785 - 791
[3] Patent: US2008/319194, 2008, A1. Location in patent: Page/Page column 4
[4] Molecules, 2018, vol. 23, # 1,
[5] RSC Advances, 2016, vol. 6, # 81, p. 77717 - 77734
2-Amino-4,5-dimethoxybenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
2-Amino-4,5-dimethoxybenzoic acid Suppliers
- Tel
- --
- Fax
- --
- chemcontrol@nextra.sk
- Country
- Slovakia
- ProdList
- 6700
- Advantage
- 60
View Lastest Price from 2-Amino-4,5-dimethoxybenzoic acid manufacturers
- Product
- 2-Amino-4,5-dimethoxybenzoic acid 5653-40-7
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 30tons/month
- Release date
- 2023-01-18
- Product
- 2-Amino-4,5-dimethoxybenzoic acid 5653-40-7
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 ton
- Release date
- 2024-12-24
- Product
- 2-Amino-4,5-dimethoxybenzoic acid 5653-40-7
- Price
- US $60.00/KG
- Min. Order
- 1KG
- Purity
- 99.9%
- Supply Ability
- 100000kg
- Release date
- 2024-08-13