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Diflucortolone valerate

Product Name
Diflucortolone valerate
CAS No.
59198-70-8
Chemical Name
Diflucortolone valerate
Synonyms
DFV;Temetex;Afusona;Texmeten;Nerisone;Nerisona;Neriforte;21-Valerate;Nerisone Forte;DIFLUCORTOLONE VALERATE
CBNumber
CB7420627
Molecular Formula
C27H36F2O5
Formula Weight
478.57
MOL File
59198-70-8.mol
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Diflucortolone valerate Property

Melting point:
220°C
alpha 
D22 +100.8° (dioxane)
Boiling point:
578.5±50.0 °C(Predicted)
Density 
1.1227 (estimate)
storage temp. 
-20°C Freezer, Under inert atmosphere
solubility 
Chloroform (Slightly), Dioxane (Slightly), Methanol (Slightly)
form 
Solid
pka
12.89±0.70(Predicted)
color 
White to Off-White
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Safety

Toxicity
Approx LD50 in mice, rats: >4, 3.1 g/kg orally; 180, 13 mg/kg s.c.; 450, 98 mg/kg i.p. (Gunzel).
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H360May damage fertility or the unborn child

H372Causes damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P314Get medical advice/attention if you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
BP401
Product name
Diflucortolone valerate
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
100MG
Price
$266
Updated
2024/03/01
TRC
Product number
D445620
Product name
Diflucortolone21-Valerate
Packaging
50mg
Price
$820
Updated
2021/12/16
TRC
Product number
D445620
Product name
Diflucortolone21-Valerate
Packaging
2.5mg
Price
$95
Updated
2021/12/16
TRC
Product number
D445620
Product name
Diflucortolone21-Valerate
Packaging
10mg
Price
$185
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD65004
Product name
Diflucortolone valerate
Packaging
10mg
Price
$60
Updated
2021/12/16
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Diflucortolone valerate Chemical Properties,Usage,Production

Originator

Nerisone,Schering,UK,1976

Uses

The 9α-fluoro derivative of Fluocortolone (F500500). Anti-inflammmatory.

Definition

ChEBI: Diflucortolone valerate is a corticosteroid hormone.

Manufacturing Process

16α-Methyl-6α,9α-difluoro-δ4-pregnene-11α,21-diol-3,20-dione-21-acetate (MP = 229°/232°-234°C (with decomposition) is dehydrogenated in 1.2- position by means of Bacillus lentus, Mutant MB 284, whereby the 21-acetate group is simultaneously saponified. (It is possible under the same conditions to start with the free 21-hydroxyl compound.)
For this purpose a fermenter made of stainless steel having a 50 liter capacity is charged with 30 liters of a nutrient solution of 0.1% yeast extract, 0.5% cornsteep and 0.2% glucose, heated for one-half hour at 120°C for sterilization purposes, and after cooling, inoculated with a bacterial suspension of Bacillus lentus MB 284.
After 24 hours of growth at 28°C under stirring (220 revolutions per minute) and aeration (1.65 m3/hr), 1.8 liters of the obtained culture is removed under sterile conditions and transferred with 28 liters of the same sterilized nutrient medium into a fermenter of the same size.
Simultaneously, 6 g of 16α-methyl-6α,9α-difluoro-δ4-pregnene-11β,21-diol3,20-dione-21-acetate in 200 cc of dimethylformamide are added and the fermentation is continued for 50 hours under the same conditions.
The course of the fermentation is tested by removal of samples which are extracted with methyl isobutyl ketone. The extracts are analyzed by thin layer chromatography using a system of benzene/ethyl acetate (4:1).
After further working up there is obtained an oily crystalline residue which is subjected to chromatography on silica gel. The 16α-methyl-6α,9α-difluoroδ1,4-pregnadien-11β,21-diol-3,20-dione is eluated with ethyl acetatechloroform (1:2), it is recrystallized from ethyl acetate/ether and then formed to melt at 240°/242°-244°C. The yield is 60% of the theoretical. The product is reacted with valeric acid chloride to give the valerate ester.

Therapeutic Function

Antiinflammatory

Diflucortolone valerate Preparation Products And Raw materials

Raw materials

Preparation Products

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Diflucortolone valerate Suppliers

GUANGZHOU TOPWORK CHEMISTRY CO.,LTD.
Tel
020-87317062 13048089691
Email
852378519@qq.com
Country
China
ProdList
160
Advantage
58
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810
Fax
025-57019371
Email
sales@sunlidabio.com
Country
China
ProdList
3239
Advantage
55
Shanghai ChuangYan Chemical Technology Co., Ltd.
Tel
021-11111111 11111111111
Fax
qq:546919421
Email
546919421@qq.com
Country
China
ProdList
3216
Advantage
55
Shanghai Kewel Chemical Co., Ltd.
Tel
021-64609169 18901607656
Fax
021-64609160
Email
greensnown@163.com
Country
China
ProdList
9906
Advantage
50
Alta Scientific Co., Ltd.
Tel
022-6537-8550 15522853686
Fax
022-2532-9655
Email
sales@altasci.com.cn
Country
China
ProdList
4511
Advantage
55
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
Chengdu HuaNa Chemicals Co., Ltd.
Tel
028-86612776; 13699069380
Fax
-
Email
515238037@qq.com
Country
China
ProdList
965
Advantage
55
Raw material medicin reagent co.,Ltd
Tel
Email
sales@njromanme.com
Country
China
ProdList
4529
Advantage
58
Wellman Pharmaceutical Group Limited
Tel
027-83778875 15807197853
Fax
027-83991220
Email
15807197853@163.com
Country
China
ProdList
4027
Advantage
58
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View Lastest Price from Diflucortolone valerate manufacturers

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Product
Diflucortolone Valerate 59198-70-8
Price
US $0.00/g
Min. Order
1g
Purity
More Than 99%
Supply Ability
100kg/Month
Release date
2024-09-06
Shaanxi TNJONE Pharmaceutical Co., Ltd
Product
Diflucortolone valerate 59198-70-8
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20tons
Release date
2024-04-01
Longyan Tianhua Biological Technology Co., Ltd
Product
Diflucortolone valerate 59198-70-8
Price
US $85.00/KG
Min. Order
1KG
Purity
99
Supply Ability
1000KG
Release date
2020-11-12

59198-70-8, Diflucortolone valerateRelated Search:


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  • valeric acid [2-[(6S,8S,9R,10S,11S,13S,14S,16R,17S)-6,9-difluoro-11-hydroxy-3-keto-10,13,16-trimethyl-7,8,11,12,14,15,16,17-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-keto-ethyl] ester
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  • C27H36F2O5
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