Agmatine sulfate

ChemicalBook > CAS DataBase List > Agmatine sulfate

General Uses

Product Name: Agmatine sulfate
CAS No.: 2482-00-0
Chemical Name: Agmatine sulfate
Synonyms: AGMATINE SULPHATE;2-(4-aminobutyl)guanidine,sulfuric acid;gmatine sulfate;agmatine sulfate salt;1-AMINO-4-GUANIDINOBUTANE SULFATE SALT;ARGAMINE;matine SuL;Agmatine SuL;Agmatine sulfat;AGMATINE SULFATE
CBNumber: CB7421831
Molecular Formula: C5H16N4O4S
Formula Weight: 228.27
MOL File: 2482-00-0.mol

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Agmatine sulfate Property

Melting point:: 234-238 °C(lit.)
RTECS: ME8413000
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: H₂O: 50 mg/mL
form: powder
color: white to off-white
Water Solubility: Soluble in water, nearly insoluble in alcohol
Merck: 14,188
BRN: 3918807
InChI: InChI=1S/C5H14N4.H2O4S/c6-3-1-2-4-9-5(7)8;1-5(2,3)4/h1-4,6H2,(H4,7,8,9);(H2,1,2,3,4)
InChIKey: PTAYFGHRDOMJGC-UHFFFAOYSA-N
SMILES: C(CCCN)NC(N)=N.S(O)(O)(=O)=O
CAS DataBase Reference: 2482-00-0(CAS DataBase Reference)

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
F: 10
HS Code: 29252900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A7127
Product name: Agmatine sulfate salt
Purity: ≥97%, powder
Packaging: 1g
Price: $89
Updated: 2024/03/01

TCI Chemical

Product number: A0310
Product name: Agmatine Sulfate
Purity: >98.0%(T)
Packaging: 1g
Price: $48
Updated: 2024/03/01

TCI Chemical

Product number: A0310
Product name: Agmatine Sulfate
Purity: >98.0%(T)
Packaging: 100mg
Price: $17
Updated: 2024/03/01

Alfa Aesar

Product number: H55363
Product name: Agmatine sulfate, 97%
Packaging: 1g
Price: $61.7
Updated: 2024/03/01

Alfa Aesar

Product number: H55363
Product name: Agmatine sulfate, 97%
Packaging: 5g
Price: $216
Updated: 2024/03/01

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Agmatine sulfate Chemical Properties,Usage,Production

General Uses

Neuroprotective, CNS studies, Autism and depression research
Description: Agmatine Sulfate is a polyamine derived from L-arginine decarboxylation and is a known putative endogenous neurotransmitter at imidazoline receptors. Agmatine sulfate displaces clonidine at α2-adrenergic and at imidazoline receptors and was recently shown to exert some neuroprotective effects. It blocks NMDA-receptor associated cation channels. Acts as a competitive inhibitor of nitric oxide synthase (NOS). It functions as neurotransmitter since it is stored in synaptic vesicles and is related from axon terminals by depolarization(1). Protects autistic behavior in rats and reverses depressive like behavior in mice.

Description

Agmatine sulfate is the sulfate of the Agmatine. Agmatine is an aninoguanidine that is naturally derived from the arginine. It can exert modulatory effect on many molecular targets such as neurotransmitter systems, opioid analgesia, ion channels, and nitric oxide (NO) synthesis and polyamine metabolism. It has been also found that it can reverse the pain induced from inflammation, neuropathy, and spinal cord injury. Those effects make it a potential candidate for multiple pharmacological applications in the future.

Chemical Properties

White to off-white powder

Uses

Agmatine Sulfate is a a polyamine derived from L-arginine (A769500) decarboxylation and is a known putative endogenous neurotransmitter at imidazoline receptors. Agmatine sulfate displaces clonidine a t α2-adrenergic and at imidazoline receptors and was recently shown to exert some neuroprotective effects.

Uses

Agmatine is an intermediate in the biosynthesis of the polyamines putrescine and spermine. Agmatine binds with high affinity to α2-adrenergic receptors and imidazoline binding sites and produces blockade of the NMDA-receptor associated cation channels. Agmatine is a competitive inhibitor of nitric oxide synthase activity owing to mimicry of the natural NOS substrate arginine.

Biological Activity

Arginine metabolite that is synthesized within bovine brain and exhibits clonidine-displacing substance (CDS) activity. Putative endogenous ligand for the imidazoline binding site.

Biochem/physiol Actions

Putative endogenous neurotransmitter at imidazoline receptors; displaces clonidine at α2-adrenergic and at imidazoline receptors; blocks NMDA-activated ion channels in hippocampal neurons.

Purification Methods

Crystallise the salt from aqueous MeOH. The free base has m 101.5-103o, the gold chloride hydrochloride crystallises from H2O with m 223o(dec), and the picrate has m 236-238o. [Odo J Chem Soc Jpn 67 132 1946, Beilstein 4 I 420, 4 II 703, 4 III 575, 4 IV 1291.]

References

Fairbanks, C. A., et al. "Agmatine reverses pain induced by inflammation, neuropathy, and spinal cord injury." Proceedings of the National Academy of Sciences of the United States of America97.19(2000):10584.
Kolesnikov, Yuri, S. Jain, and G. W. Pasternak. "Modulation of opioid analgesia by agmatine." European Journal of Pharmacology296.1(1996):17-22.
Su, R. B., J. Li, and B. Y. Qin. "A biphasic opioid function modulator: agmatine. "Acta Pharmacologica Sinica24.7(2003):631.
Galea, Elena, et al. "Inhibition of mammalian nitric oxide synthases by agmatine, an endogenous polyamine formed by decarboxylation of arginine." Biochemical Journal 316 ( Pt 1).1(1996):247.
https://en.wikipedia.org/wiki/Agmatine

Agmatine sulfate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Agmatine sulfate manufacturers

Wuhan Haorong Biotechnology Co.,Ltd

Product: Agmatine sulfate 2482-00-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 5000
Release date: 2023-08-07

Shaanxi TNJONE Pharmaceutical Co., Ltd

Product: 1-Amino-4-Guanidinobutane Sulfate Salt; Agmatine sulfate; Agmatine Sulphate 2482-00-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000kg
Release date: 2024-05-15

Hebei Shengyang Water Conservancy Engineering Co., Ltd.

Product: Agmatine sulfate 2482-00-0
Price: US $18.00-18.00/kg
Min. Order: 1kg
Purity: 99.9
Supply Ability: 5000
Release date: 2024-05-09

2482-00-0, Agmatine sulfate Related Search:

Ferrous sulfate monohydrate SODIUM SULFATE Colistin sulfate Magnesium sulfate Amikacin Disulfate Copper(II) sulfate Zinc sulphate Atropine sulfate DOBUTAMINE D-Glucosamine sulfate FERROUS SULFATE Neomycin sulfate SULFATE STANDARD Sodium sulfate Salbutamol Magnesium sulfate heptahydrate Ammonium sulfate calcium sulfate Agmatine Sulfate Salt

N-(4-AMINOBUTYL)GUANIDINE SULFATE

N-(4-Aminobutyl)guanidine sulfate salt

1-AMINO-4-GUANIDINOBUTANE SULFATE

1-AMINO-4-GUANIDINOBUTANE SULFATE SALT

1-AMINO-4-GUANIDOBUTANE SULFATE

4-GUANIDINOBUTANE SULFATE

4-GUANIDINO-BUTYLAMINE SULFATE

4-GUANIDINO-BUTYLAMINE SULFATE SALT

(4-AMINOBUTYL)GUANIDINE SULFATE

(4-aminobutyl)guanidinium sulphate

AGMATINE SULFATE

AGMATINE SULPHATE

ARGAMINE

ARGAMINE SULFATE

agmatine sulfate salt

AGMATINESULFATE,POWDER

(4-Aminobutyl)guanidinium sulfate.

AGMATINE SULFATE PRACTICAL GRADE

AGMATINE SULFATE((4-AMINOBUTYL)GUANIDINE)

matine SuL

2-(4-aminobutyl)guanidine,sulfuric acid

4minobutyl)guanidinium sulphate

Agmatine sulfate price

gmatine sulfate

AGARICUSBLAZTIP.E

1-Amino-4-guanidinobutane sulfate salt, 4-Guanidinobutylamine sulfate salt, N-(4-Aminobutyl)guanidine sulfate salt

1-(4-aMinobutyl)guanidine sulfate

Agmatine sulfate,99%

Agmatine sulfate,85+%

Agmatine sulfate,70%

ArgaMine · sulfate, 4-Guanidino-butylaMine · sulfate

AGMATINE SULFATE SALT(P)

4-Guanidinobutylamine sulphate salt

guanidinobutane sulfate salt

N-(4-Aminobutyl)guanidine sulfate sal

Agmatine sulfate≥ 93% (HPLC)

1-Amino-4-guanidinobutane sulfate salt, 97% White to off-white powder

Agmatine Sulfate &gt

Guanidine, N-(4-aminobutyl)-, sulfate (1:1)

Agmatine SuL

2-(4-aminobutyl)guanidine,sulfuricaci

High Quality Factory Supply Bulk Agmatine Sulfate

AGMATINE SULFATE /CAS 2482-00-0

1-(4-Aminobutyl)guanidine sulfate(Chunks or pellets)

Agmatine sulftae（Fermented）

Guanidine butylamine sulfate

Agmatine sulfate(Fermented)

Agmatine sulfat

Prinomastat Impurity 9

2482-00-0

2428-00-0

2482-00-1

2842-00-0

C5H16N4O4S

H2NCH24NHCNHNH2H2SO4

C5H14N4H2SO4C5H16N4O4S

C5H14N4H2SO4

Putative endogenous neurotransmitter at imidazoline receptors; displaces clonidine at alpha2-adrenergic and at imidazoline receptors; blocks NMDA-activated ion channels in hippocampal neurons.