ChemicalBook > CAS DataBase List > 2,3-Dichloro-5-(trifluoromethyl)pyridine

2,3-Dichloro-5-(trifluoromethyl)pyridine

Product Name
2,3-Dichloro-5-(trifluoromethyl)pyridine
CAS No.
69045-84-7
Chemical Name
2,3-Dichloro-5-(trifluoromethyl)pyridine
Synonyms
DCTF;2,3,5-DCTF;5-DCTF;BUTTPARK 45\10-37;AKOS BBS-00006992;TIMTEC-BB SBB006729;2,3-Dichloro-5-(trif;2,3-Dichloro-5-(Trifluoromethy;Gingerol Impurity 3 (8-Gingerol);3-Dichloro-5-trifluoroMethylpyridine
CBNumber
CB7421992
Molecular Formula
C6H2Cl2F3N
Formula Weight
215.99
MOL File
69045-84-7.mol
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2,3-Dichloro-5-(trifluoromethyl)pyridine Property

Melting point:
8-9 °C
Boiling point:
80 °C20 mm Hg(lit.)
Density 
1.549 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.475(lit.)
Flash point:
175 °F
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
soluble in Chloroform, Methanol
pka
-3.34±0.10(Predicted)
form 
Liquid
Specific Gravity
1.549
color 
Clear colorless to yellow
InChI
InChI=1S/C6H2Cl2F3N/c7-4-1-3(6(9,10)11)2-12-5(4)8/h1-2H
InChIKey
ABNQGNFVSFKJGI-UHFFFAOYSA-N
SMILES
C1(Cl)=NC=C(C(F)(F)F)C=C1Cl
CAS DataBase Reference
69045-84-7(CAS DataBase Reference)
EPA Substance Registry System
2,3-Dichloro-5-(trifluoromethyl)pyridine (69045-84-7)
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Safety

Hazard Codes 
Xn,N,Xi
Risk Statements 
20/22-41-43-51/53-36/37/38
Safety Statements 
24-26-37/39-61-36
RIDADR 
UN 3082 9/PG 3
WGK Germany 
2
Hazard Note 
Irritant
TSCA 
Yes
HazardClass 
9
PackingGroup 
III
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H317May cause an allergic skin reaction

H318Causes serious eye damage

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
366145
Product name
2,3-Dichloro-5-(trifluoromethyl)pyridine
Purity
97%
Packaging
25g
Price
$32.1
Updated
2023/06/20
TCI Chemical
Product number
D2214
Product name
2,3-Dichloro-5-(trifluoromethyl)pyridine
Purity
>95.0%(GC)
Packaging
25g
Price
$30
Updated
2025/07/31
TRC
Product number
D436370
Product name
2,3-Dichloro-5-(trifluoromethyl)pyridine
Packaging
100g
Price
$250
Updated
2021/12/16
Oakwood
Product number
004746
Product name
2,3-Dichloro-5-(trifluoromethyl)pyridine
Purity
99%
Packaging
5g
Price
$10
Updated
2021/12/16
AK Scientific
Product number
A510
Product name
2,3-Dichloro-5-trifluoromethylpyridine
Packaging
5g
Price
$13
Updated
2021/12/16
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2,3-Dichloro-5-(trifluoromethyl)pyridine Chemical Properties,Usage,Production

Chemical Properties

Light yellow liquid

Uses

2,3-Dichloro-5-(trifluoromethyl)pyridine is a reactant that has been used in the synthesis of a 17b-HSD1 inhibitor.

General Description

2,3-Dichloro-5-(trifluoromethyl)pyridine is reported as an intermediate of herbicide. Synthesis of 2,3-dichloro-5-(trifluoromethyl)pyridine has been reported. Palladium-catalyzed monoalkoxycarbonylation of 2,3-dichloro-5-(trifluoromethyl)pyridine has been reported.

Synthesis

69045-83-6

69045-84-7

General procedure for the synthesis of 2,3-dichloro-5-trichloromethylpyridine from 2,3-dichloro-5-trichloromethylpyridine: 26.5 g (0.1 mol) of 2,3-dichloro-5-trichloromethylpyridine and 0.2 g of tungsten hexachloride were added to a reactor, which was heated to 170 °C under atmospheric pressure. Subsequently, about 20 g of hydrogen fluoride was slowly added. The reaction was terminated when the composition of the reaction product no longer changed. The unreacted hydrogen fluoride was recovered by condensation and the generated hydrogen chloride was removed by absorption. The reaction solution was cooled to room temperature and then transferred to an autoclave, heated to 180°C, maintained at a pressure of 0.2 MPa, and reacted for 5 hours. After completion of the reaction, the reaction mixture was cooled and sampled for analysis. The results showed that the product contained 94% of 2,3-dichloro-5-trifluoromethylpyridine and 92% purity.

References

[1] Patent: CN106397309, 2017, A. Location in patent: Paragraph 0023; 0024; 0025; 0025; 0026-0030
[2] Heterocycles, 1984, vol. 22, # 1, p. 117 - 124
[3] Patent: WO2014/198278, 2014, A1. Location in patent: Page/Page column 8; 9; 12
[4] Patent: CN104557683, 2016, B. Location in patent: Paragraph 0021; 0022
[5] Patent: US4590279, 1986, A

2,3-Dichloro-5-(trifluoromethyl)pyridine Preparation Products And Raw materials

Raw materials

2-Amino-5-methylpyridine 2,3-Dichloro-5-(trichloromethyl)pyridine 2-Chloro-5-trichloromethylpyridine Hydrogen fluoride 2-Chloro-5-methylpyridine

Preparation Products

3-CHLORO-2-HYDROXY-5-(TRIFLUOROMETHYL)PYRIDINE
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View Lastest Price from 2,3-Dichloro-5-(trifluoromethyl)pyridine manufacturers

Shandong Jihui Chemical Co., Ltd.
Product
2,3-Dichloro-5-(trifluoromethyl)pyridine 69045-84-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
Purity: 99.5%
Supply Ability
1000tons
Release date
2025-07-18
Shaanxi Dideu New Materials Co. Ltd
Product
2,3-Dichloro-5-(trifluoromethyl)pyridine 69045-84-7
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1000kg
Release date
2025-06-11
Hebei Chuanghai Biotechnology Co., Ltd
Product
2,3-Dichloro-5-(trifluoromethyl)pyridine 69045-84-7
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-29

69045-84-7, 2,3-Dichloro-5-(trifluoromethyl)pyridineRelated Search:

2,3-Dichloropropene Ferric chloride 2-Chloro-4-(trifluoromethyl)pyridine 2-Chloro-5-trifluoromethylpyridine 3-Trifluoromethylpyridine 3-AMINO-2,6-DICHLORO-4-(TRIFLUOROMETHYL)PYRIDINE,3-Amino-2,6-dichloro-4-(trifluoromethyl)pyridine 98%,3-Amino-2,6-dichloro-4-(trifluoromethyl)pyridine98% 2,6-DICHLORO-4-(TRIFLUOROMETHYL)PYRIDINE 3-CYANO-2,6-DICHLORO-4-(TRIFLUOROMETHYL)PYRIDINE,3-Cyano-2,6-dichloro-4-(trifluoromethyl)pyridine98%,3-Cyano-2,6-dichloro-4-(trifluoromethyl)pyridine 98% 2,6-DICHLORO-3-(TRIFLUOROMETHYL)PYRIDINE, PURISS, 98%,2,6-DICHLORO-3-(TRIFLUOROMETHYL)PYRIDINE,2,6-DICHLORO-3-[TRIFLUOROMETHYL]-PYRIDINE 99+% 2,4-dichloro-6-(trifluoromethyl)pyrimidine 2,6-DICHLORO-4-(TRIFLUOROMETHYL)NICOTINAMIDE 2,5-DICHLORO-3-(TRIFLUOROMETHYL)PYRIDINE 2,5-Dichloro-4-(trifluoromethyl)pyridine 2,3-Dichloro-6-(trifluoromethyl)pyridine 2,6-DICHLORO-4-(TRIFLUOROMETHYL)PYRIDINE-3-METHYLAMINE 3,5-Dichloro-2-(trifluoromethyl)pyridine 2,6-DICHLORO-4-(TRIFLUOROMETHYL)PYRIDINE-3- 2,6-DICHLORO-4-(TRIFLUOROMETHYL)PYRIDINE-3-METHYLAMIN

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  • 69045-84-7
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