17a-Ethynyl-1,3,5(10)-estratriene-3,17b-diol 3-methyl ether

Product Name: 17a-Ethynyl-1,3,5(10)-estratriene-3,17b-diol 3-methyl ether
CAS No.: 72-33-3
Chemical Name: 17a-Ethynyl-1,3,5(10)-estratriene-3,17b-diol 3-methyl ether
Synonyms: 33355;EE3ME;d-MVE;sc4725;RS 1044;Devocin;Norquen;Ovastol;SC 4725;MESTRANOL
CBNumber: CB7426942
Molecular Formula: C21H26O2
Formula Weight: 310.43
MOL File: 72-33-3.mol

More

Less

17a-Ethynyl-1,3,5(10)-estratriene-3,17b-diol 3-methyl ether Property

Melting point:: 153-155 °C(lit.)
Boiling point:: 390.58°C (rough estimate)
alpha: +2～+8°(D/20℃)(c=1, 1,4-dioxane)
Density: 1.0865 (rough estimate)
refractive index: 1.4900 (estimate)
storage temp.: Sealed in dry,2-8°C
solubility: Acetonitrile: 1 mg/ml; Ethanol: 1 mg/ml; Methanol: 1 mg/ml
form: Solid
pka: 13.10±0.40(Predicted)
color: White to off-white
optical activity: [α]15/D +3°, c = 2 in dioxane
Merck: 5917
BRN: 2625905
CAS DataBase Reference: 72-33-3(CAS DataBase Reference)
NIST Chemistry Reference: Mestranol(72-33-3)
EPA Substance Registry System: Mestranol (72-33-3)

More

Less

Safety

Hazard Codes: Xn
Risk Statements: 36/37/38-40-48-68
Safety Statements: 22-26-36/37/39-45-36/37
WGK Germany: 3
RTECS: RC8960000
HS Code: 29372900
Hazardous Substances Data: 72-33-3(Hazardous Substances Data)
Toxicity: LD50 oral in rat: > 10gm/kg

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H351Suspected of causing cancer

Precautionary statements

P201Obtain special instructions before use.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 855871
Product name: Mestranol
Purity: 99%
Packaging: 500mg
Price: $79
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1394008
Product name: Mestranol
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200mg
Price: $164.8
Updated: 2024/03/01

Cayman Chemical

Product number: 23822
Product name: Mestranol
Purity: ≥98%
Packaging: 10mg
Price: $26
Updated: 2024/03/01

Cayman Chemical

Product number: 23822
Product name: Mestranol
Purity: ≥98%
Packaging: 50mg
Price: $98
Updated: 2024/03/01

Sigma-Aldrich

Product number: M0600000
Product name: Mestranol
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: m0600000
Price: $60
Updated: 2024/03/01

More

Less

17a-Ethynyl-1,3,5(10)-estratriene-3,17b-diol 3-methyl ether Chemical Properties,Usage,Production

Chemical Properties

Crystalline Solid

Originator

Enovid ,Searle ,US ,1957

Uses

Pharmacological estrogen molecule

Uses

Mestranol is an orally active estrogenic steroid. It was the estrogen used in many of the first oral contraceptives

Uses

antiemetic

Definition

ChEBI: A terminal acetylenic compound that is (17alpha)-17-ethynylestra-1(10),2,4-triene substituted by a methoxy group at position 3 and a hydroxy group at position 17.

Manufacturing Process

A stirred solution of 120 parts of 3-methoxy-δ1,3,5-estratrien-17-one in 2,600 parts of anhydrous toluene and 4,300 parts of anhydrous ether is saturated with a slow stream of acetylene. In the course of 30 minutes there is added a solution of 120 parts of potassium tert-amylate in 2,800 parts of anhydrous tert-pentanol. The passage of acetylene and stirring are continued for an additional 5 hours after which the reaction mixture is washed 5 times with 3,000-part portions of saturated ammonium chloride solution and then with water. It is then dried over anhydrous sodium sulfate and concentrated to dryness under vacuum. The residue is recrystallized from methanol. The 3- methoxy-17-ethynyl-δ1,3,5 estratrien-17-ol thus obtained melts at about 143° to 146°C. A further recrystallization from acetone yields crystals melting at about 150° to 151°C.

Therapeutic Function

Estrogen

Safety Profile

Confirmed carcinogen with experimental. neoplastigenic, tumorigenic, and teratogenic data. Moderately toxic by subcutaneous route. Human reproductive effects by ingestion: changes in ovaries and fallopian tubes, ferthty effects. Experimental reproductive effects. Mutation data reported. An FDA proprietary drug. A steroid used in oral contraceptives. When heated to decomposition it emits acrid smoke and irritating fumes.

17a-Ethynyl-1,3,5(10)-estratriene-3,17b-diol 3-methyl ether Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

17a-Ethynyl-1,3,5(10)-estratriene-3,17b-diol 3-methyl ether Suppliers

Belgium 1 Canada 1 China 127 Europe 2 France 2 Germany 3 India 4 Japan 2 Russia 1 Switzerland 1 United Kingdom 11 United States 36 Global 191

Carbosynth

Tel: --
Fax: --
Email: sales@carbosynth.com
Country: United Kingdom
ProdList: 6005
Advantage: 58

Apin Chemicals Limited (UK)

Tel: --
Fax: --
Email: info@apinchemicals.com
Country: United Kingdom
ProdList: 6184
Advantage: 60

Whyte Chemicals

Tel: --
Fax: --
Email: sales@whytechemicals.co.uk
Country: United Kingdom
ProdList: 3748
Advantage: 50

Leancare Ltd.

Tel: --
Fax: --
Email: enquiry@leancare.co.uk
Country: United Kingdom
ProdList: 6446
Advantage: 42

CARBONE SCIENTIFIC CO.,LTD

Tel: --
Fax: --
Email: sales@carbonesci.com
Country: United Kingdom
ProdList: 6666
Advantage: 30

ETA SCIENTIFIC Co.,Ltd

Tel: --
Fax: --
Email: sales@etascientific.com
Country: United Kingdom
ProdList: 6090
Advantage: 34

UK GREEN SCIENTIFIC CO.,LIMITED

Tel: --
Fax: --
Email: sales@gs-chem.com
Country: United Kingdom
ProdList: 6098
Advantage: 47

Eurolabs Limited

Tel: --
Fax: --
Country: United Kingdom
ProdList: 6309
Advantage: 46

VWR International

Tel: --
Fax: --
Email: solutions@vwr.com
Country: United Kingdom
ProdList: 6548
Advantage: 82

Zerenex Molecular Limited

Tel: --
Fax: --
Email: sales@zerenex-molecular.com
Country: United Kingdom
ProdList: 6204
Advantage: 47

Sequoia Research Products Ltd.

Tel: --
Fax: --
Email: sales@seqchem.com
Country: United Kingdom
ProdList: 3113
Advantage: 69

More

Less

View Lastest Price from 17a-Ethynyl-1,3,5(10)-estratriene-3,17b-diol 3-methyl ether manufacturers

Wuhan Han Sheng New Material Technology Co.，Ltd

Product: mestranol 72-33-3
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50TONS
Release date: 2023-04-19

Guangzhou Biocar Biotechnology Co.,Ltd.

Product: mestranol 72-33-3
Price: US $1.00/g
Min. Order: 10g
Purity: 99.5%
Supply Ability: 1000kg
Release date: 2022-01-12

Shanghai Biolang Biotechnology Co., Ltd.

Product: mestranol 72-33-3
Price: US $9.90-7.70/g
Min. Order: 10g
Purity: 99.99%HPLC.USP42
Supply Ability: 1000kgs
Release date: 2022-02-22

72-33-3, 17a-Ethynyl-1,3,5(10)-estratriene-3,17b-diol 3-methyl etherRelated Search:

Tibolone EQUILIN Estradiol valerate Mifepristone Ethynyl estradiol NOR-1 EPIMESTROL Quinestrol 17a-Ethynyl-1,3,5(10)-estratriene-3,17b-diol 3-methyl ether Nilestriol Infecundin 17ALPHA-ETHYNYLESTRADIOL-2,4,16,16-D4 3-METHYL ETHER Noracycline Etamestrol 17ALPHA-ETHYNYLESTRADIOL-16,16-D2 3-METHYL ETHER 1,3,5(10)-ESTRATRIEN-17ALPHA-ETHYNYL-3,17BETA-DIOL 3-BENZOATE 1,3,5(10)-ESTRATRIEN-17-ALPHA-ETHYNYL-3,17-BETA-DIOL 3-GLUCOSIDURONATE, SODIUM SALT Norinyl

Ethynylestradiol 3-methyl ether,97%

17alpha-19-Norpregna-1,3,5(10)-trien-20-yn

MESTRANOL

19-Nor-17alpha-pregna-1,3,5(10)-trien-20-yn-17-ol, 3-methoxy-

19-nor-17α-pregna-1,3,5(10)-trien-20-yn-17-ol,3-methoxy-

19-Norpregna-1,3,5(10)-trien-20-yn-17-ol, 3-methoxy-, (17alpha)-

3,17-beta-Dihydroxy-17-alpha-ethynyl-1,3,5(10)-estratriene-3-methyl ether

3,17-beta-dihydroxy-17-alpha-ethynyl-1,3,5(10)-estratriene-3-methylether

33355

3-methoxy-17a-ethynyl-1,3,5(10)-estratriene-17b-ol

3-methoxy-17-alpha-19-norpregna-1,3,5(10)-trien-20-yn-17-ol

3-methoxy-17-alpha-ethinylestradiol

3-Methoxy-17alpha-ethinylestradiol

3-methoxy-17-alpha-ethinyloestradiol

3-Methoxy-17alpha-ethinyloestradiol

3-methoxy-19-nor-17α-pregna-1,2,5(10)-triene-20-yn-17-ol

3-Methoxyethynylestradiol

3-methoxyethynyloestradiol

3-Methylethynylestradiol

3-methylethynyloestradiol

3-O-Methylethynylestradiol

5(10)-trien-17-beta-ol,17-alpha-ethynyl-3-methoxy-estra-3

5(10)-trien-20-yn-17-ol,3-methoxy-17-alpha-19-norpregna-3

8027 C. B.

component of Norinyl

component of Norquen

component of Ortho-Novum

component of Ovulen

Compound 33355

compound33355

delta-MVE

sc4725

ETHYNYLESTRADIOL 3-METHYL ETHER

ETHINYLESTRADIOL METHYL ETHER

3-METHOXY-17ALPHA-ETHYNYLESTRADIOL

(8R,9S,13S,14S,17R)-17-ETHYNYL-3-METHOXY-13-METHYL-7,8,9,11,12,13,14,15,16,17-DECAHYDRO-6H-CYCLOPENTA[A]PHENANTHREN-17-OL

17a-ethynyl-1,3,5(10)-estratriene-3,17b-diol 3-methyl ether

17A-ETHYNYLESTRADIOL 3-METHYLTHER

(17A)-3-METHOXY-19-NORPREGMA-1,3,5(10)-TRIEN-20-YN-17-OL

17-ALPHA-ETHINYL-OESTRADIOL-3-METHYL ETHER

17ALPHA-ETHYNYL-1,3,5(10)-ESTRATRIENE-3,17BETA-DIOL 3-METHYL ETHER

17ALPHA-ETHYNYLESTRADIOL 3-METHYL ETHER

1,3,5(10)-ESTRATRIEN-17-ALPHA-ETHYNYL-3,17-BETA-DIOL 3-METHYL ETHER

3-Methoxy-19-nor-17α-pregna-1,3,5[10]-trien-20-yn-17-ol

17a-Ethynyl-3-methoxy-17b-hydroxy-1,3,5(10)-estratriene

3-Methoxy-17a-ethynylestradiol

(17a)-3-Methoxy-19-norpregna-1,3,5(10)-trien-20-yn-17-ol

Menophase

17α-ethynyl-1,3,5(10)-estratriene-3,17β-diol 3-methyl ether

17a-Ethinylestradiol 3-methyl ether

17a-Ethynyl-3-methoxy-1,3,5(10)-estratrien-17b-ol

17a-Ethynyl-3-methoxy-17b-hydroxy-D1,3,5(10)-estratriene

17a-Ethynylestradiol methyl ether

17-Ethynyl-3-methoxy-1,3,5(10)-estratrien-17b-o1

17-Ethynyl-3-methoxyestra-1,3,5(10)-trien-17b-ol

19-Nor-17a-pregna-1,3,5(10)-trien-20-yn-17-ol, 3-methoxy- (6CI, 8CI)

MESTRANOL, VETRANAL 100MG

MESTRANOL 98+%