3-(T-BUTYLDIMETHYLSILOXY)PROPANOL

Product Name: 3-(T-BUTYLDIMETHYLSILOXY)PROPANOL
CAS No.: 73842-99-6
Chemical Name: 3-(T-BUTYLDIMETHYLSILOXY)PROPANOL
Synonyms: 3-((tert-ButyldiMethylsilyl)oxy)propan-1-ol;3-[(TERT-BUTYLDIMETHYLSILYL)OXY]-1-PROPANOL;DK879;DKSI028;AKOS 90371;DKFELEX0233;TBDMS-Pr-OH;3-(T-BUTYLDIMETHYLSILOXY)PROPANOL;3-(t-butyldimethylsilyloxy)propanol;3-(T-Butyldimethylsiloxy)propan-1-ol
CBNumber: CB7443927
Molecular Formula: C9H22O2Si
Formula Weight: 190.36
MOL File: 73842-99-6.mol

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3-(T-BUTYLDIMETHYLSILOXY)PROPANOL Property

Boiling point:: 110 °C6 mm Hg(lit.)
Density: 0.892 g/mL at 25 °C(lit.)
refractive index: n20/D 1.4350(lit.)
Flash point:: 199 °F
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Dichloromethane, Ether, Ethyl Acetate, Hexane, Methanol
form: Clear Colourless Liquid
pka: 14.87±0.10(Predicted)
Specific Gravity: 0.892
color: Colorless to Almost colorless
Hydrolytic Sensitivity: 7: reacts slowly with moisture/water
InChI: InChI=1S/C9H22O2Si/c1-9(2,3)12(4,5)11-8-6-7-10/h10H,6-8H2,1-5H3
InChIKey: NETUFVYVNJNFMU-UHFFFAOYSA-N
SMILES: C(O)CCO[Si](C(C)(C)C)(C)C

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Safety

WGK Germany: 3
TSCA: No
HS Code: 2931900090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 555886
Product name: 3-((tert-Butyldimethylsilyl)oxy)-propanol
Purity: 97%
Packaging: 5ml
Price: $82.6
Updated: 2025/07/31

Sigma-Aldrich

Product number: 555886
Product name: 3-((tert-Butyldimethylsilyl)oxy)-propanol
Purity: 97%
Packaging: 25ml
Price: $196.5
Updated: 2025/07/31

TCI Chemical

Product number: B5555
Product name: 3-[[tert-Butyl(dimethyl)silyl]oxy]-1-propanol
Purity: >96.0%(GC)
Packaging: 1mL
Price: $54
Updated: 2025/07/31

TCI Chemical

Product number: B5555
Product name: 3-[[tert-Butyl(dimethyl)silyl]oxy]-1-propanol
Purity: >96.0%(GC)
Packaging: 5mL
Price: $158
Updated: 2025/07/31

TRC

Product number: B691575
Product name: 3-[(tert-Butyldimethylsilyl)oxy]-1-propanol
Packaging: 500mg
Price: $50
Updated: 2021/12/16

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3-(T-BUTYLDIMETHYLSILOXY)PROPANOL Chemical Properties,Usage,Production

Chemical Properties

Clear Colourless Liquid

Uses

3-(T-butyldimethylsiloxy)propanol is primarily used as a protective group in organic synthesis, specifically for protecting alcohol or phenol functional groups. It can also act as a coupling agent, adhesion promoter, and forms periodic mesoporous silicas.

General Description

3-((tert-Butyldimethylsilyl)oxy)-propanol (3-[(tert-butyldimethylsilyl)oxy]-1-propanol) is formed as an intermediate during the synthesis of 3-(tert-butyldimethylsilyl)oxy]propanal.

Synthesis

18162-48-6

504-63-2

73842-99-6

The general procedure for the synthesis of 3-(tert-butyldimethylsilyloxy)propanol from tert-butyldimethylchlorosilane and 1,3-propanediol is as follows: this synthesis has been reported in the literature as part of the exemplary "bottom fragment "15 for the preparation of dictyostatin and its analogs. Specifically, 1,3-propanediol is converted in nine steps to the known bis-TBS-protected Homer-Wadsworth-Emmons product by an Evans chirality-assisted method.10 For related literature, see Phukan, P.; Sasmal, S.; Maier, M. E. Eur. J. Org. Chem. 2003, 1733 and Andrus, S., S., S., S., S., S., S., S., S., and S.. 2003, 1733 and Andrus, M. B.; Argade, A. B. Tetrahedron Lett. 1996, 37, 5049.

References

[1] Patent: WO2005/117588, 2005, A2. Location in patent: Page/Page column 31
[2] Journal of the American Chemical Society, 2004, vol. 126, # 37, p. 11440 - 11441
[3] Organic Letters, 2007, vol. 9, # 16, p. 3105 - 3108
[4] Patent: WO2014/145302, 2014, A2. Location in patent: Page/Page column 34; 35; 38; 39
[5] Patent: WO2016/44558, 2016, A1. Location in patent: Page/Page column 51; 52; 54; 55

3-(T-BUTYLDIMETHYLSILOXY)PROPANOL Preparation Products And Raw materials

Raw materials

Preparation Products

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3-(T-BUTYLDIMETHYLSILOXY)PROPANOL Suppliers

Americas 1 Canada 1 China 111 Europe 1 Germany 2 India 6 Japan 1 Singapore 1 Switzerland 2 United Kingdom 2 United States 12 Global 140

Shanghai Guijing New Material Technology Co., Ltd.

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View Lastest Price from 3-(T-BUTYLDIMETHYLSILOXY)PROPANOL manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 3-{[tert-Butyl(dimethyl)silyl]oxy}propan-1-ol 73842-99-6
Price: US $1.10-9.90/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 100kg
Release date: 2025-08-18

Shanghai Daken Advanced Materials Co.,Ltd

Product: 3-(T-BUTYLDIMETHYLSILOXY)PROPANOL 73842-99-6
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.00%
Supply Ability: 1000KG /month
Release date: 2021-11-26

Career Henan Chemical Co

Product: 3-(T-BUTYLDIMETHYLSILOXY)PROPANOL 73842-99-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-25

73842-99-6, 3-(T-BUTYLDIMETHYLSILOXY)PROPANOLRelated Search:

5-O-tert-Butyldiphenylsilyl-2,3-O-isopropylidene-D-ribofuranose 3-(tert-Butyldimethylsilyloxy)glutaric anhydride DMT-2'O-TBDMS-rA(bz) Phosphoramidite (3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one DMT-2′O-TBDMS-rU Phosphoramidite N-blocked-5'-O-DMT-2'-O-TBDMS CED cytidine phosphoramidite 3,4-DI-O-ACETYL-6-O-(TERT-BUTYLDIPHENYLSILYL)-D-GLUCAL 5-O-(TERT-BUTYLDIMETHYLSILYL)-2,3-O-ISOPROPYLIDENE-D-RIBONIC ACID GAMMA-LACTONE (2',5'-bis-O-(tert-butyldimethylsilyl)-beta-ribofuranosyl)-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)thymine TRI-O-(TERT-BUTYLDIMETHYLSILYL)-D-GLUCAL 3,4-DI-O-ACETYL-6-O-(TERT-BUTYLDIMETHYLSILYL)-D-GLUCAL METHYL (S)-(-)-4-BROMO-3-TERT-BUTYLDIMETHYLSILYLOXYBUTANOATE 6-O-(TERT-BUTYLDIPHENYLSILYL)-D-GLUCAL 3-(T-BUTYLDIMETHYLSILOXY)PROPANOL 5'-O-(4,4'-DIMETHOXYTRITYL)-N6-BENZOYL-R-ADENOSINE-3'-T-BUTYLDIMETHYLSILYL-2'-(2-CYANOETHYL-N,N-DIISOPROPYL)PHOSPHORAMIDITE N2-(ISOBUTYRYL)-5'-O-(DIMETHOXYTRITYL)-2'-O-(T-BUTYLDIMETHYLSILYL)-GUANOSINE-3'-N,N-DIISOPROPYL (CYANOETHYL) PHOSPHORAMIDITE 3,6-DI-O-(TERT-BUTYLDIPHENYLSILYL)-D-GLUCAL 3-FORMYL-6-(S)-T-BUTYL- DIMETHYLSILOXYMETHYL-7-(R)-TETRAHYDROPYRANYLOXY-(1S,5S)-BICYCLO-(3,3,0)-OCT-2-(E)-ENE

AKOS 90371

3-(T-BUTYLDIMETHYLSILOXY)PROPANOL

3-[(TERT-BUTYLDIMETHYLSILYL)OXY]-1-PROPANOL

3-[(TERT-BUTYLDIMETHYLSILYL)OXY]PROPANOL

3-(TERT-BUTYLDIMETHYLSILOXY)PROPANOL

3-(T-Butyldimethylsiloxy)propan-1-ol

3-(tert-ButyldiMethylsilanyloxy)propan-1-ol

3-[[(1,1-DiMethylethyl)diMethylsilyl]oxy]-1-propanol

1-Propanol, 3-[[(1,1-diMethylethyl)diMethylsilyl]oxy]-

3-((tert-ButyldiMethylsilyl)oxy)propan-1-ol

3-((tert-ButyldiMethylsilyl)oxy)-propanol 97%

3-[Dimethyl(1,1-dimethylethyl)siloxy]propanol

DK879

DKFELEX0233

3-(t-butyldimethylsilyloxy)propanol

DKSI028

3-((<i>tert</i>-Butyldimethylsilyl)oxy)-propanol

TBDMS-Pr-OH

73842-99-6

CH33CSiCH32OCH2CH2CH2OH

Oxygen Compounds

Organic Building Blocks

C9 to C30

Alcohols

Building Blocks

Miscellaneous Reagents

Alcohols

C9 to C30

Oxygen Compounds