ChemicalBook > CAS DataBase List > 3-(T-BUTYLDIMETHYLSILOXY)PROPANOL

3-(T-BUTYLDIMETHYLSILOXY)PROPANOL

Product Name
3-(T-BUTYLDIMETHYLSILOXY)PROPANOL
CAS No.
73842-99-6
Chemical Name
3-(T-BUTYLDIMETHYLSILOXY)PROPANOL
Synonyms
3-((tert-ButyldiMethylsilyl)oxy)propan-1-ol;3-[(TERT-BUTYLDIMETHYLSILYL)OXY]-1-PROPANOL;DK879;DKSI028;AKOS 90371;DKFELEX0233;TBDMS-Pr-OH;3-(T-BUTYLDIMETHYLSILOXY)PROPANOL;3-(t-butyldimethylsilyloxy)propanol;3-(T-Butyldimethylsiloxy)propan-1-ol
CBNumber
CB7443927
Molecular Formula
C9H22O2Si
Formula Weight
190.36
MOL File
73842-99-6.mol
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3-(T-BUTYLDIMETHYLSILOXY)PROPANOL Property

Boiling point:
110 °C6 mm Hg(lit.)
Density 
0.892 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.4350(lit.)
Flash point:
199 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Dichloromethane, Ether, Ethyl Acetate, Hexane, Methanol
form 
Clear Colourless Liquid
pka
14.87±0.10(Predicted)
Specific Gravity
0.892
color 
Colorless to Almost colorless
Hydrolytic Sensitivity
7: reacts slowly with moisture/water
InChI
InChI=1S/C9H22O2Si/c1-9(2,3)12(4,5)11-8-6-7-10/h10H,6-8H2,1-5H3
InChIKey
NETUFVYVNJNFMU-UHFFFAOYSA-N
SMILES
C(O)CCO[Si](C(C)(C)C)(C)C
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Safety

WGK Germany 
3
TSCA 
No
HS Code 
2931900090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
555886
Product name
3-((tert-Butyldimethylsilyl)oxy)-propanol
Purity
97%
Packaging
5ml
Price
$82.6
Updated
2025/07/31
Sigma-Aldrich
Product number
555886
Product name
3-((tert-Butyldimethylsilyl)oxy)-propanol
Purity
97%
Packaging
25ml
Price
$196.5
Updated
2025/07/31
TCI Chemical
Product number
B5555
Product name
3-[[tert-Butyl(dimethyl)silyl]oxy]-1-propanol
Purity
>96.0%(GC)
Packaging
1mL
Price
$54
Updated
2025/07/31
TCI Chemical
Product number
B5555
Product name
3-[[tert-Butyl(dimethyl)silyl]oxy]-1-propanol
Purity
>96.0%(GC)
Packaging
5mL
Price
$158
Updated
2025/07/31
TRC
Product number
B691575
Product name
3-[(tert-Butyldimethylsilyl)oxy]-1-propanol
Packaging
500mg
Price
$50
Updated
2021/12/16
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3-(T-BUTYLDIMETHYLSILOXY)PROPANOL Chemical Properties,Usage,Production

Chemical Properties

Clear Colourless Liquid

Uses

3-(T-butyldimethylsiloxy)propanol is primarily used as a protective group in organic synthesis, specifically for protecting alcohol or phenol functional groups. It can also act as a coupling agent, adhesion promoter, and forms periodic mesoporous silicas.

General Description

3-((tert-Butyldimethylsilyl)oxy)-propanol (3-[(tert-butyldimethylsilyl)oxy]-1-propanol) is formed as an intermediate during the synthesis of 3-(tert-butyldimethylsilyl)oxy]propanal.

Synthesis

18162-48-6

504-63-2

73842-99-6

The general procedure for the synthesis of 3-(tert-butyldimethylsilyloxy)propanol from tert-butyldimethylchlorosilane and 1,3-propanediol is as follows: this synthesis has been reported in the literature as part of the exemplary "bottom fragment "15 for the preparation of dictyostatin and its analogs. Specifically, 1,3-propanediol is converted in nine steps to the known bis-TBS-protected Homer-Wadsworth-Emmons product by an Evans chirality-assisted method.10 For related literature, see Phukan, P.; Sasmal, S.; Maier, M. E. Eur. J. Org. Chem. 2003, 1733 and Andrus, S., S., S., S., S., S., S., S., S., and S.. 2003, 1733 and Andrus, M. B.; Argade, A. B. Tetrahedron Lett. 1996, 37, 5049.

References

[1] Patent: WO2005/117588, 2005, A2. Location in patent: Page/Page column 31
[2] Journal of the American Chemical Society, 2004, vol. 126, # 37, p. 11440 - 11441
[3] Organic Letters, 2007, vol. 9, # 16, p. 3105 - 3108
[4] Patent: WO2014/145302, 2014, A2. Location in patent: Page/Page column 34; 35; 38; 39
[5] Patent: WO2016/44558, 2016, A1. Location in patent: Page/Page column 51; 52; 54; 55

3-(T-BUTYLDIMETHYLSILOXY)PROPANOL Preparation Products And Raw materials

Raw materials

Preparation Products

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3-(T-BUTYLDIMETHYLSILOXY)PROPANOL Suppliers

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View Lastest Price from 3-(T-BUTYLDIMETHYLSILOXY)PROPANOL manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
3-{[tert-Butyl(dimethyl)silyl]oxy}propan-1-ol 73842-99-6
Price
US $1.10-9.90/kg
Min. Order
1kg
Purity
99%min
Supply Ability
100kg
Release date
2025-08-18
Shanghai Daken Advanced Materials Co.,Ltd
Product
3-(T-BUTYLDIMETHYLSILOXY)PROPANOL 73842-99-6
Price
US $0.00/KG
Min. Order
1KG
Purity
98.00%
Supply Ability
1000KG /month
Release date
2021-11-26
Career Henan Chemical Co
Product
3-(T-BUTYLDIMETHYLSILOXY)PROPANOL 73842-99-6
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2019-12-25

73842-99-6, 3-(T-BUTYLDIMETHYLSILOXY)PROPANOLRelated Search:

5-O-tert-Butyldiphenylsilyl-2,3-O-isopropylidene-D-ribofuranose 3-(tert-Butyldimethylsilyloxy)glutaric anhydride DMT-2'O-TBDMS-rA(bz) Phosphoramidite (3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one DMT-2′O-TBDMS-rU Phosphoramidite N-blocked-5'-O-DMT-2'-O-TBDMS CED cytidine phosphoramidite 3,4-DI-O-ACETYL-6-O-(TERT-BUTYLDIPHENYLSILYL)-D-GLUCAL 5-O-(TERT-BUTYLDIMETHYLSILYL)-2,3-O-ISOPROPYLIDENE-D-RIBONIC ACID GAMMA-LACTONE (2',5'-bis-O-(tert-butyldimethylsilyl)-beta-ribofuranosyl)-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)thymine TRI-O-(TERT-BUTYLDIMETHYLSILYL)-D-GLUCAL 3,4-DI-O-ACETYL-6-O-(TERT-BUTYLDIMETHYLSILYL)-D-GLUCAL METHYL (S)-(-)-4-BROMO-3-TERT-BUTYLDIMETHYLSILYLOXYBUTANOATE 6-O-(TERT-BUTYLDIPHENYLSILYL)-D-GLUCAL 3-(T-BUTYLDIMETHYLSILOXY)PROPANOL 5'-O-(4,4'-DIMETHOXYTRITYL)-N6-BENZOYL-R-ADENOSINE-3'-T-BUTYLDIMETHYLSILYL-2'-(2-CYANOETHYL-N,N-DIISOPROPYL)PHOSPHORAMIDITE N2-(ISOBUTYRYL)-5'-O-(DIMETHOXYTRITYL)-2'-O-(T-BUTYLDIMETHYLSILYL)-GUANOSINE-3'-N,N-DIISOPROPYL (CYANOETHYL) PHOSPHORAMIDITE 3,6-DI-O-(TERT-BUTYLDIPHENYLSILYL)-D-GLUCAL 3-FORMYL-6-(S)-T-BUTYL- DIMETHYLSILOXYMETHYL-7-(R)-TETRAHYDROPYRANYLOXY-(1S,5S)-BICYCLO-(3,3,0)-OCT-2-(E)-ENE

  • AKOS 90371
  • 3-(T-BUTYLDIMETHYLSILOXY)PROPANOL
  • 3-[(TERT-BUTYLDIMETHYLSILYL)OXY]-1-PROPANOL
  • 3-[(TERT-BUTYLDIMETHYLSILYL)OXY]PROPANOL
  • 3-(TERT-BUTYLDIMETHYLSILOXY)PROPANOL
  • 3-(T-Butyldimethylsiloxy)propan-1-ol
  • 3-(tert-ButyldiMethylsilanyloxy)propan-1-ol
  • 3-[[(1,1-DiMethylethyl)diMethylsilyl]oxy]-1-propanol
  • 1-Propanol, 3-[[(1,1-diMethylethyl)diMethylsilyl]oxy]-
  • 3-((tert-ButyldiMethylsilyl)oxy)propan-1-ol
  • 3-((tert-ButyldiMethylsilyl)oxy)-propanol 97%
  • 3-[Dimethyl(1,1-dimethylethyl)siloxy]propanol
  • DK879
  • DKFELEX0233
  • 3-(t-butyldimethylsilyloxy)propanol
  • DKSI028
  • 3-((<i>tert</i>-Butyldimethylsilyl)oxy)-propanol
  • TBDMS-Pr-OH
  • 73842-99-6
  • CH33CSiCH32OCH2CH2CH2OH
  • Oxygen Compounds
  • Organic Building Blocks
  • C9 to C30
  • Alcohols
  • Building Blocks
  • Miscellaneous Reagents
  • Alcohols
  • C9 to C30
  • Oxygen Compounds