5-Nitroisophthalic acid
Uses- Product Name
- 5-Nitroisophthalic acid
- CAS No.
- 618-88-2
- Chemical Name
- 5-Nitroisophthalic acid
- Synonyms
- 5-NIPA;5-Nitro-isopht;5-NitroisophthaL;5-Nitroisophthalic a;5itroIsophathalicAcid;NITRO ISOPHTHALIC ACID;Gronbromide impurity A;NITROISOPHTHALIC-5 ACID;5-Nitro-m-phthalic acid;5-NITROISOPHTHALIC ACID
- CBNumber
- CB7462421
- Molecular Formula
- C8H5NO6
- Formula Weight
- 211.13
- MOL File
- 618-88-2.mol
5-Nitroisophthalic acid Property
- Melting point:
- 259-261 °C(lit.)
- Boiling point:
- 350.79°C (rough estimate)
- Density
- 1.6342 (rough estimate)
- vapor pressure
- 0Pa at 25℃
- refractive index
- 1.5282 (estimate)
- Flash point:
- 120°C
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Acetonitrile (Slightly, Heated), DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 2.81±0.10(Predicted)
- color
- White to Off-White
- Water Solubility
- Soluble in water.1.5 g/L at 20°C
- BRN
- 1976587
- LogP
- 1.1 at 25℃
- CAS DataBase Reference
- 618-88-2(CAS DataBase Reference)
- EPA Substance Registry System
- 5-Nitroisophthalic acid (618-88-2)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-40
- Safety Statements
- 26-36-22
- RIDADR
- 2811
- WGK Germany
- 3
- TSCA
- Yes
- HS Code
- 29173990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- PHR2465
- Product name
- Glycopyrrolate Related Compound A
- Purity
- Pharmaceutical Secondary Standard; Certified Reference Material
- Packaging
- 100MG
- Price
- $574
- Updated
- 2025/07/31
- Product number
- N18005
- Product name
- 5-Nitroisophthalic acid
- Purity
- 98%
- Packaging
- 100g
- Price
- $29.7
- Updated
- 2025/07/31
- Product number
- 1296029
- Product name
- Glycopyrrolate Related Compound A
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 50mg
- Price
- $1300
- Updated
- 2025/07/31
- Product number
- N0520
- Product name
- 5-Nitroisophthalic Acid
- Purity
- >99.0%(HPLC)
- Packaging
- 25g
- Price
- $20
- Updated
- 2025/07/31
- Product number
- N0520
- Product name
- 5-Nitroisophthalic Acid
- Purity
- >99.0%(HPLC)
- Packaging
- 500g
- Price
- $72
- Updated
- 2025/07/31
5-Nitroisophthalic acid Chemical Properties,Usage,Production
Uses
5-Nitrobenzene-1,3-Dicarboxylic Acid is used in the synthesis of Glycopyrrolate, a novel pharmaceutical compound based on PDE IV inhibitors; used in the treatment of respiratory complaints. Also used in the synthesis of coordination polymers.
Chemical Properties
LIGHT CREAM CRYSTALLINE POWDER
Uses
pharmaceutical intermediate
Uses
5-Nitroisophthalic acid is used as an intermediate of medicine compound and as a disperser in dyes. It is used as an intermediate in organic synthesis,agrochemical,pharmaceutical and dyestuffs etc,.
Flammability and Explosibility
Non flammable
Synthesis
121-91-5
618-88-2
The general procedure for the synthesis of 5-nitroisophthalic acid from isophthalic acid is as follows: concentrated sulfuric acid (120 mL, 2.21 mol) was added to a three-neck flask, followed by isophthalic acid (80 g, 0.48 mol). The mixture was heated to 75 °C and maintained at this temperature for 0.5 h under stirring conditions. 60% nitric acid (73.5 g, 0.70 mol) was slowly added dropwise, with the rate of acceleration of the drop being controlled to ensure completion of the drop within 2 to 2.5 hours. After the dropwise addition was completed, the reaction mixture was continued to be stirred at 75 °C for 2 hours. Subsequently, the temperature was raised to 90 °C and the reaction continued for 1 hour. Upon completion of the reaction, the mixture was cooled to below 50 °C and 120 mL of water was slowly added dropwise. The mixture was further cooled to room temperature, filtered, and the spent acid was removed by filtration. The filter cake was washed three times with pure water to remove the wash water. Pure water (120 mL) was added to the filter cake, stirred and heated until dissolved, stirring the mixture thoroughly. Hot filtration was carried out, cooled and crystallized, and the filter cake was dried to give a white crystalline solid 5-nitroisophthalic acid (89.6 g) in 88.3% yield.
References
[1] Patent: CN107721859, 2018, A. Location in patent: Paragraph 0025; 0027; 0029; 0031; 0033; 0034; 0035; 0036
[2] RSC Advances, 2016, vol. 6, # 10, p. 8495 - 8502
[3] Journal fuer Praktische Chemie (Leipzig), 1986, vol. 328, # 4, p. 497 - 514
[4] Langmuir, 2016, vol. 32, # 36, p. 9301 - 9312
[5] Acta Crystallographica Section C: Crystal Structure Communications, 1999, vol. 55, # 11, p. 1845 - 1847
5-Nitroisophthalic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Nitroisophthalic acid manufacturers
- Product
- 5-Nitroisophthalic acid 618-88-2
- Price
- US $0.00/KG
- Min. Order
- 25KG
- Purity
- 98%min
- Supply Ability
- 30tons/month
- Release date
- 2023-02-02
- Product
- 5-Nitroisophthalic acid 618-88-2
- Price
- US $25.00/ASSAYS
- Min. Order
- 100ASSAYS
- Purity
- 99.5%
- Supply Ability
- 100 mt
- Release date
- 2024-11-19
- Product
- 5-Nitroisophthalic acid 618-88-2
- Price
- US $11.16/Kg/Drum
- Min. Order
- 25Kg/Drum
- Purity
- 99.00%HPLC
- Supply Ability
- 20tons/month
- Release date
- 2021-09-23