ABX-1431

Product Name: ABX-1431
CAS No.: 1446817-84-0
Chemical Name: ABX-1431
Synonyms: CS-2856;ABX-1431;Elcubragistat;ABX1431;ABX 1431;ABX-1431, 10 mM in DMSO;ABX-1431,inhibit,ABX 1431,Monoacylglycerol lipase,ABX1431,MAGL,Inhibitor;1,1,1,3,3,3-Hexafluoro-2-propyl 4-[2-(1-Pyrrolidinyl)-4-(trifluoromethyl)benzyl]piperazine-1-carboxylate;1,1,1,3,3,3-Hexafluoropropan-2-yl 4-(2-(pyrrolidin-1-yl)-4-(trifluoromethyl)benzyl)piperazine-1-carboxylate;1,1,1,3,3,3-hexafluoropropan-2-yl 4-{[2-(pyrrolidin-1-yl)-4-(trifluoromethyl)phenyl]me thyl}piperazine-1-carboxylate;1-Piperazinecarboxylic acid, 4-[[2-(1-pyrrolidinyl)-4-(trifluoromethyl)phenyl]methyl]-, 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester
CBNumber: CB74667484
Molecular Formula: C20H22F9N3O2
Formula Weight: 507.39
MOL File: 1446817-84-0.mol

More

Less

ABX-1431 Property

storage temp.: -20°C
solubility: Soluble in DMSO (>25 mg/ml)
form: solid
color: White
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChI: InChI=1S/C20H22F9N3O2/c21-18(22,23)14-4-3-13(15(11-14)31-5-1-2-6-31)12-30-7-9-32(10-8-30)17(33)34-16(19(24,25)26)20(27,28)29/h3-4,11,16H,1-2,5-10,12H2
InChIKey: SQZJGTOZFRNWCX-UHFFFAOYSA-N
SMILES: N1(C(OC(C(F)(F)F)C(F)(F)F)=O)CCN(CC2=CC=C(C(F)(F)F)C=C2N2CCCC2)CC1

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 26023
Product name: ABX-1431
Packaging: 1mg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 26023
Product name: ABX-1431
Packaging: 50mg
Price: $1184
Updated: 2024/03/01

Cayman Chemical

Product number: 26023
Product name: ABX-1431
Packaging: 5mg
Price: $179
Updated: 2024/03/01

Cayman Chemical

Product number: 26023
Product name: ABX-1431
Packaging: 10mg
Price: $333
Updated: 2024/03/01

AK Scientific

Product number: 0863DV
Product name: CID71657619
Packaging: 10mg
Price: $245
Updated: 2021/12/16

More

Less

ABX-1431 Chemical Properties,Usage,Production

Description

ABX-1431 (1446817-84-0) is a potent (IC50 = 14 nM in vitro, 2.2 nM in human PC3 cells) and very selective (>100-fold over hABHD6, >200-fold over hPLA2G7) inhibitor of monoacylglycerol lipase (MAGL).1 Active in a rat formalin pain test at 3mg/kg. Orally bioavailable and CNS penetrant.

Uses

Elcubragistat (ABX-1431) is a highly potent, selective, and orally available, CNS-penetrant monoacylglycerol lipase (MAGL) inhibitor with an IC50 of 14 nM.

in vivo

Elcubragistat (ABX-1431) inhibits MGLL activity in rodent brain (ED₅₀=0.5-1.4 mg/kg), increases brain 2-AG concentrations, and suppresses pain behavior in the rat formalin pain model^[1].

References

[1] JUSTIN S. CISAR. Identification of ABX-1431, a Selective Inhibitor of Monoacylglycerol Lipase and Clinical Candidate for Treatment of Neurological Disorders[J]. Journal of Medicinal Chemistry, 2018, 61 20: 9062-9084. DOI:10.1021/acs.jmedchem.8b00951

ABX-1431 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

ABX-1431 Suppliers

China 62 India 1 United States 8 Global 71

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 12952
Advantage: 65

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

Aladdin Scientific

Tel
Email: tp@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354;
Email: support@targetmol.com
Country: United States
ProdList: 39035
Advantage: 58

Focus Biomolecules

Tel: --
Fax: --
Email: sales@focusbiomolecules.com
Country: United States
ProdList: 1284
Advantage: 58

Cayman Chemical Company

Tel: --
Fax: --
Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
Advantage: 81

1446817-84-0, ABX-1431Related Search:

Tigecycline 9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea methanesulfonate (1:1) AZ20 SGI 7079 Gilteritinib N-(1,1-Dimethylethyl)-3-[[5-methyl-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]amino]benzenesulfonamide N2-[2-Methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-1,3,5-triazine-2,4-diamine UNC2541

CS-2856

ABX1431;ABX 1431

ABX-1431

1-Piperazinecarboxylic acid, 4-[[2-(1-pyrrolidinyl)-4-(trifluoromethyl)phenyl]methyl]-, 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester

1,1,1,3,3,3-hexafluoropropan-2-yl 4-{[2-(pyrrolidin-1-yl)-4-(trifluoromethyl)phenyl]me thyl}piperazine-1-carboxylate

1,1,1,3,3,3-Hexafluoropropan-2-yl 4-(2-(pyrrolidin-1-yl)-4-(trifluoromethyl)benzyl)piperazine-1-carboxylate

ABX-1431,inhibit,ABX 1431,Monoacylglycerol lipase,ABX1431,MAGL,Inhibitor

Elcubragistat

1,1,1,3,3,3-Hexafluoro-2-propyl 4-[2-(1-Pyrrolidinyl)-4-(trifluoromethyl)benzyl]piperazine-1-carboxylate

ABX-1431, 10 mM in DMSO

1446817-84-0

C20H22F9N3O2