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UC2288

Product Name
UC2288
CAS No.
1394011-91-6
Chemical Name
UC2288
Synonyms
UC2288;UC2288 ，E1190;UC 2288, trans;p21 Inhibitor, UC2288;UC2288, 10 mM in DMSO;UC2288, p21 inhibitor;1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(trans-4-((5-(trifluoromethyl)pyridin-2-yl)oxy)cyclohexyl)urea;Urea, N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-[trans-4-[[5-(trifluoromethyl)-2-pyridinyl]oxy]cyclohexyl]-;rac-1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-((1R,4R)-4-((5-(trifluoromethyl)pyridin-2-yl)oxy)cyclohexyl)urea;1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(trans-4-((5-(trifluoromethyl)pyridin-2-yl)oxy)cyclohexyl)urea , UC2288
CBNumber
CB74718667
Molecular Formula
C20H18ClF6N3O2
Formula Weight
481.82
MOL File
1394011-91-6.mol
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UC2288 Property

Boiling point:
491.9±45.0 °C(Predicted)
Density 
1.45±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMF: 25 mg/ml; DMSO: 25 mg/ml; Ethanol: 25 mg/ml
form 
A solid
pka
12.88±0.40(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
5.32813
Product name
p21 Inhibitor, UC2288
Packaging
10 mg
Price
$263
Updated
2025/07/31
Ambeed
Product number
A1462621
Product name
1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(trans-4-((5-(trifluoromethyl)pyridin-2-yl)oxy)cyclohexyl)urea
Purity
98%
Packaging
100mg
Price
$65
Updated
2021/12/16
Ambeed
Product number
A1462621
Product name
1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(trans-4-((5-(trifluoromethyl)pyridin-2-yl)oxy)cyclohexyl)urea
Purity
98%
Packaging
250mg
Price
$97
Updated
2021/12/16
Ambeed
Product number
A1462621
Product name
1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(trans-4-((5-(trifluoromethyl)pyridin-2-yl)oxy)cyclohexyl)urea
Purity
98%
Packaging
1g
Price
$241
Updated
2021/12/16
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UC2288 Chemical Properties,Usage,Production

Uses

UC2288 is a potent and orally active p21 attenuator (relatively selective activity for p21), which is synthesized based Sorafenib (HY-10201). UC2288 potently inhibits cancer cell growth by inducing apoptosis. UC2288 has no inhibition of VEGFR2 and Raf kinases even at 10 μM[1].

Biological Activity

Cell permeable: yes

in vivo

UC2888 (oral gavage; 15 mg/kg; 3 times a week; 4 weeks) co-treatment with imetelstat significantly suppresses tumor growth and does not effect mice weight[2].UC2288 (intraperitoneal injection; 10 mg/kg; 4 times in 7 days) attenuates MPTP-induced behavioral impairment, prevents activation of MAPK pathway in the MPTP-treated mice brain. MPTP treatment raises TNF-α, IL-6 and IL-1β levels in MPTP treated mice brain, but UC2288 signicantly decreases MPTP-induced TNF-α, IL-6 levels, but IL-1β is not decreased in brain[3].

Animal Model:Eight-week old, athymic nude (NCr nu/nu) mice injected subcutaneously with HCT116 and ACHN cancer cells(2.5x106)[2]
Dosage:15 mg/kg
Administration:Oral gavage; 3 times a week; 4 weeks; co-treatment with imetelstat
Result:Combined treatment with imetelstat synergistically inhibited tumor growth in mice.
Animal Model:MPTP-induced C57BL6 Parkinson’s disease mice model[3]
Dosage:10 mg/kg
Administration:Intraperitoneal?injection; 4 times in 7 days
Result:Ameliorated MPTP induced PD progression through inhibition of neuroinammation.

References

[1] Hiromi I Wettersten, et al. A Novel p21 Attenuator Which Is Structurally Related to Sorafenib. Cancer Biol Ther.?2013 Mar;14(3):278-85. DOI:10.4161/cbt.23374
[2] Romi Gupta, et al. Synergistic tumor suppression by combined inhibition of telomerase and CDKN1A. Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):E3062-71. DOI:10.1073/pnas.1411370111
[3] Jun Hyung Im, et al. p21 inhibitor UC2288 ameliorates MPTP induced Parkinson’s disease progression through inhibition of oxidative stress and neuroinammation. Translational Medicine.Neurobiology of Disease

UC2288 Preparation Products And Raw materials

Raw materials

Preparation Products

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UC2288 Suppliers

China 38 United States 6 Global 44
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
52923
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
58
Abcam Limited
Tel
--
Fax
--
Email
us.orders@abcam.com
Country
United States
ProdList
6001
Advantage
50
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81

1394011-91-6, UC2288Related Search:

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  • UC2288
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  • Attenuator,786-O,Inhibitor,UC-2288,MDM-2/p53,inhibit,UC2288,ovarian,RCC,HK2,UC 2288,p21,sorafenib,p53-mutant,cancer
  • Urea, N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-[trans-4-[[5-(trifluoromethyl)-2-pyridinyl]oxy]cyclohexyl]-
  • UC 2288, trans
  • 1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(trans-4-((5-(trifluoromethyl)pyridin-2-yl)oxy)cyclohexyl)urea , UC2288
  • UC2288, p21 inhibitor
  • UC2288, 10 mM in DMSO
  • p21 Inhibitor, UC2288
  • rac-1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-((1R,4R)-4-((5-(trifluoromethyl)pyridin-2-yl)oxy)cyclohexyl)urea
  • UC2288 ，E1190
  • 1394011-91-6