CAERULOMYCIN A

Product Name: CAERULOMYCIN A
CAS No.: 21802-37-9
Chemical Name: CAERULOMYCIN A
Synonyms: CERULOMYCIN;CAERULOMYCIN;AERULOMYCIN A;Carulomycin A;CAERULOMYCIN A;Caerulomycin, Cerulomycin;CeruloMycin, CaeruloMycin A;Fungal,Antibiotic,Caerulomycin A,inhibit,Inhibitor;4-Methoxy-2,2'-bipyridine-6-carbaldehyde (E)-oxime;(E)-4-Methoxy-[2,2'-bipyridine]-6-carbaldehyde oxime
CBNumber: CB7484496
Molecular Formula: C12H11N3O2
Formula Weight: 229.23
MOL File: 21802-37-9.mol

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CAERULOMYCIN A Property

Melting point:: 173 °C
Boiling point:: 420.0±45.0 °C(Predicted)
Density: 1.23±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in DMSO (up to 10 mg/ml).
form: solid
pka: 9.89±0.50(Predicted)
color: White
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C6374
Product name: Caerulomycin A
Purity: from
Packaging: 1mg
Price: $449
Updated: 2024/03/01

Cayman Chemical

Product number: 27625
Product name: Caerulomycin A
Packaging: 1mg
Price: $340
Updated: 2024/03/01

Cayman Chemical

Product number: 27625
Product name: Caerulomycin A
Packaging: 5mg
Price: $1186
Updated: 2024/03/01

TRC

Product number: C700030
Product name: Caerulomycin A
Packaging: 1mg
Price: $395
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb546133
Product name: Caerulomycin A
Purity: >98%
Packaging: 100μg
Price: $209.1
Updated: 2021/12/16

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CAERULOMYCIN A Chemical Properties,Usage,Production

Description

Caerulomycin A (21802-37-9) chemically novel and potent immunosuppressive agent. Suppresses T cell activation and IFN7gamma; secretion?in vitro?and?in vivo.1 Caerulomycin A induces expansion of regulatory T cells by via interfering with IFNγ -induced STAT1 signaling.2

Uses

Caerulomycin is a rare and unusual antibiotic containing a core 2, 2’-bispyridyl with an oxime substituent, produced by a strain of Streptomyces caeruleus isolated in Canada in 1959. Caerulomycin is active against fungi and some protozoans, and is weakly active against bacteria. While its discovery has stimulated some synthetic effort, little is known about the mode and spectrum of action of caerulomycin.

Uses

Caerulomycin A is a pyridine derived antiobiotic with a broad spectrum of bioactivity.

Definition

ChEBI: Caerulomycin A is a pyridine alkaloid that is 2,2'-bipyridine substituted by a methoxy group at position 4 and a (E)-(hydroxyimino)methyl group at position 6. Isolated from the marine-derived actinomycete Actinoalloteichus cyanogriseus, it exhibits antineoplastic activity. It has a role as an antineoplastic agent, a marine metabolite and a bacterial metabolite. It is an aldoxime, an aromatic ether, a member of bipyridines and a pyridine alkaloid. It derives from a hydride of a 2,2'-bipyridine.

References

1) Singla?et al. (2014),?Caerulomycin A suppresses immunity by inhibiting T cell activity; PLoS One,?9(10)?e107051 2) Gurram?et al. (2014),?Caerulomycin A enhances transforming growth factor-beta (TGF-β)-Smad3 protein signaling by suppressing interferon-gamma (IFN-γ)-signaling to expand regulatory T cells (Tregs); J. Biol. Chem.?289?17515

CAERULOMYCIN A Preparation Products And Raw materials

Raw materials

Preparation Products

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CAERULOMYCIN A Suppliers

China 43 Germany 2 India 1 South Korea 1 United Kingdom 3 United States 14 Global 64

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
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BOC Sciences

Tel: 16314854226; +16314854226
Email: inquiry@bocsci.com
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InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
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TargetMol Chemicals Inc.

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Country: United States
ProdList: 38632
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Aladdin Scientific

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Country: United States
ProdList: 52925
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Focus Biomolecules

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2A PharmaChem USA

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3B Scientific Corporation

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LKT Laboratories, Inc.

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View Lastest Price from CAERULOMYCIN A manufacturers

Career Henan Chemical Co

Product: AERULOMYCIN A 21802-37-9
Price: US $1.00/g
Min. Order: 1g
Purity: ≥98%
Supply Ability: g/kg/Ton
Release date: 2019-12-25

21802-37-9, CAERULOMYCIN ARelated Search:

Apafant Tacrolimus EPA Azithromycin Doxycycline Clindamycin KANAMYCIN Spectinomycin Gentamicin 4-Hydroxy-2,6-dimethylpyridine 6-methylpyridine-2-carbaldehyde oxime 6-METHYL-2,2'-BIPYRIDINE COLLISMYCIN A CAERULOMYCIN A 4-METHOXY-2,6-DIMETHYLPYRIDINE Caerulomycin C Caerulomycin D Caerulomycin B

AERULOMYCIN A

(E)-4-Methoxy-[2,2'-bipyridine]-6-carbaldehyde oxime

4-Methoxy-2,2'-bipyridine-6-carbaldehyde (E)-oxime

(2,2'-Bipyridine)-6-carboxaldehyde, 4-methoxy-, oxime, (E)-

CeruloMycin, CaeruloMycin A

CAERULOMYCIN

CAERULOMYCIN A

Carulomycin A

CERULOMYCIN

Caerulomycin, Cerulomycin

Fungal,Antibiotic,Caerulomycin A,inhibit,Inhibitor

(E)-4-Methoxy-[2,2'-bipyridine]-6-carbaldehyde oxime

21802-37-9

C12H11N3O2

Antibiotic