(S)-(+)-4-AMINO-3-HYDROXYBUTANOIC ACID

Product Name: (S)-(+)-4-AMINO-3-HYDROXYBUTANOIC ACID
CAS No.: 7013-05-0
Chemical Name: (S)-(+)-4-AMINO-3-HYDROXYBUTANOIC ACID
Synonyms: (S)-4-AMINO-3-HYDROXYBUTANOIC ACID;S-(+)-GABOB;β-hydroxy-GABA;beta-hydroxy-GABA;(S)-(+)-3-Hydroxy-GABA;(S)-(+)-β-hydroxy-GABA;GABOB (beta-hydroxy-GABA);D-4-Amino-3-hydroxybutyric acid;(S)-4-AMINO-3-HYDROXYBUTYRIC ACID;(3S)-4-Amino-3-hydroxybutanoic acid
CBNumber: CB7488146
Molecular Formula: C4H9NO3
Formula Weight: 119.12
MOL File: 7013-05-0.mol

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(S)-(+)-4-AMINO-3-HYDROXYBUTANOIC ACID Property

Melting point:: 207-212 °C
alpha: 20 º (C=1.7 IN H2O)
Boiling point:: 374.5±32.0 °C(Predicted)
Density: 1.312±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
form: Solid
pka: 4.04±0.10(Predicted)
optical activity: [α]20/D +20.0°, c = 1.7 in H2O
InChI: InChI=1S/C4H9NO3/c5-2-3(6)1-4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1
InChIKey: YQGDEPYYFWUPGO-VKHMYHEASA-N
SMILES: C(O)(=O)C[C@H](O)CN
CAS DataBase Reference: 7013-05-0(CAS DataBase Reference)

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 542946
Product name: (S)-(+)-4-Amino-3-hydroxybutyric acid
Purity: 97%
Packaging: 5g
Price: $588
Updated: 2025/07/31

Sigma-Aldrich

Product number: 542946
Product name: (S)-(+)-4-Amino-3-hydroxybutyric acid
Purity: 97%
Packaging: 1g
Price: $153
Updated: 2023/06/20

Biosynth Carbosynth

Product number: FA165248
Product name: (S)-(+)-4-Amino-3-hydroxybutyric acid
Packaging: 2g
Price: $240
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA165248
Product name: (S)-(+)-4-Amino-3-hydroxybutyric acid
Packaging: 250mg
Price: $60
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA165248
Product name: (S)-(+)-4-Amino-3-hydroxybutyric acid
Packaging: 500mg
Price: $100
Updated: 2021/12/16

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(S)-(+)-4-AMINO-3-HYDROXYBUTANOIC ACID Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powde

Uses

S-(+)-GABOB anticonvulsant and is used in the treatment of epilepsy as it binds to the GABAB receptor.

General Description

(S)-(+)-4-Amino-3-hydroxybutyric acid [(S)-GABOB] can be prepared starting from ethyl (S)-4-chloro-3-hydroxybutyrate.

Synthesis

1431373-89-5

7013-05-0

GENERAL METHODS: Compound 7 (400 mg, 0.92 mmol) was dissolved in EtOAc (20 mL) and 10% Pd/C (785 mg, 0.74 mmol, 80 mol%) was added. The reaction system was degassed and hydrogenated under 1 atm H2 atmosphere for 12 hours. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated under reduced pressure to afford (S)-(+)-4-amino-3-hydroxybutyric acid ((S)-GABOB, 2) (95 mg, 87% yield) as a white solid. The product was purified by recrystallization from EtOH-H2O mixed solvent. Melting point: 200-202°C (literature value 13e: 198-201°C); [α]27D +17.2 (c 1.23, H2O) (literature value 13e: [α]25D +16.7 (c 0.41, H2O)).1H NMR (600 MHz, D2O): δ 2.44 (d, J = 6.6 Hz, 2H), 3.97 (dd J = 13.2, 9.6 Hz, 1H), 3.18 (dd, J = 13.2, 3.0 Hz, 1H), 4.19-4.23 (m, 1H). 13C NMR (150 MHz, D2O): δ 42.3, 44.1, 65.5, 178.6. HRMS (ESI): m/z [M + Na]+ calculated value C4H9NNaO3: 142.0480; measured value: 142.0462. ref 22: Abdel-Magid, A. F.; Carson, K.

References

[1] Tetrahedron Letters, 2013, vol. 54, # 21, p. 2637 - 2640

(S)-(+)-4-AMINO-3-HYDROXYBUTANOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-(+)-4-AMINO-3-HYDROXYBUTANOIC ACID Suppliers

China 66 France 1 Germany 2 India 1 Japan 1 Slovakia 1 Switzerland 1 United Kingdom 7 United States 18 Global 98

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View Lastest Price from (S)-(+)-4-AMINO-3-HYDROXYBUTANOIC ACID manufacturers

Shanghai UCHEM Inc.

Product: (S)-(+)-4-Amino-3-hydroxybutyric acid 7013-05-0
Price: US $209.00-954.00/g
Min. Order: 5g
Purity: 0.99
Supply Ability: 1kg
Release date: 2023-12-04

Career Henan Chemical Co

Product: (S)-(+)-4-AMINO-3-HYDROXYBUTANOIC ACID 7013-05-0
Price: US $1.00/KG
Min. Order: 1G
Purity: 98%
Supply Ability: 100KG
Release date: 2018-08-17

7013-05-0, (S)-(+)-4-AMINO-3-HYDROXYBUTANOIC ACIDRelated Search:

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(S)-4-Amino-3-hydroxybutyric acid,99%

(S)-(+)-4-Amino-3-hydroxybutyric acid 97%

GABOB (beta-hydroxy-GABA)

[S,(+)]-3-Hydroxy-4-aminobutyric acid

D-4-Amino-3-hydroxybutyric acid

S-(+)-GABOB

(S)-(+)-4-AMINO-3-HYDROXYBUTANOIC ACID

(S)-4-AMINO-3-HYDROXYBUTANOIC ACID

(S)-4-AMINO-3-HYDROXYBUTYRIC ACID

(S)-(+)-AMINO-3-HYDROXYBUTANOIC ACID

(3S)-(+)-4-Amino-3-hydroxybutanoic acid

(3S)-4-Amino-3-hydroxybutanoic acid

(S)-(+)-3-Hydroxy-GABA

(S)-(+)-β-hydroxy-GABA

Butanoic acid, 4-amino-3-hydroxy-, (3S)-

S-(+)-γ-Amino-β-hydroxybutyric acid

BUTANOIC ACID, 4-AMINO-3-HYDROXY-, (S)

beta-hydroxy-GABA

β-hydroxy-GABA

(<i>S</i>)-(+)-4-Amino-3-hydroxybutyric acid

7013-05-0

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