ChemicalBook > CAS DataBase List > Thymopentin

Thymopentin

Product Name
Thymopentin
CAS No.
69558-55-0
Chemical Name
Thymopentin
Synonyms
TP-5;RKDVY;Immunox;Timunox;ORF-15244;Thyopentin;THYMOPETIN;THYMOPENTIN;Thymopentine;ThymopentinⅡ
CBNumber
CB7491069
Molecular Formula
C30H49N9O9
Formula Weight
679.77
MOL File
69558-55-0.mol
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Thymopentin Property

Density 
1.44±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility 
DMF: 30 mg/ml; DMSO: 25 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 10 mg/ml
pka
3.07±0.10(Predicted)
form 
Powder
color 
White
CAS DataBase Reference
69558-55-0(CAS DataBase Reference)
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Safety

WGK Germany 
3
HS Code 
3504009000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T8806
Product name
Thymopentin
Purity
≥97% (HPLC)
Packaging
10mg
Price
$235
Updated
2024/03/01
Alfa Aesar
Product number
J61431
Product name
Thymopentin
Purity
99+%
Packaging
25mg
Price
$117
Updated
2023/06/20
Alfa Aesar
Product number
J61431
Product name
Thymopentin
Purity
99+%
Packaging
100mg
Price
$257
Updated
2021/12/16
Cayman Chemical
Product number
30119
Product name
Thymopentin
Packaging
5mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
30119
Product name
Thymopentin
Packaging
10mg
Price
$62
Updated
2024/03/01
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Thymopentin Chemical Properties,Usage,Production

Description

Thymopentin is a kind of peptide. Peptides and polypeptides play a critical role in the immune system and are therefore predestined as a source for new approaches in immunotherapy. Thymopentin is capable of modulating the immune response. It is a fragment of the thymopoietins (TMPOs) which is a family of nuclear protein. Studies have shown that Thymopentin is capable of affecting the function of T cells and monocytes monitored by increased cGMP level and the triggering of cellular signaling. It is also capable of improve an imbalanced immune system. As an immunomodulating agent, it is clinically used in the treatment of autoimmune diseases such as atopic dermatitis, chronic lymphocytic leukemia, Sezary’s syndrome, rheumatoid arthritis and decreased immune competency. Recent study has also shown that its immuno-modulating effect can also help fight against the infection of mycobacterium tuberculosis.

Originator

Janssen (Belgium)

Uses

Thymopentin Acetate (TP-5) is a synthetic immunomodulating pentapeptide.

Uses

immunoregulator

Definition

ChEBI: Thymopentin is an oligopeptide.

brand name

SINTOMODULINA; TIMUNOX

Clinical Use

Thymopentin is a synthetic, immunomodulating pentapeptide, representing the active fragment of the thymus hormone, thymopoietin. Thymopentin induces phenotypic differentiation and maturation of T-cells. It appears of value in the treatment of primary immune deficiency, rheumatoid arthritis, atopic dermatitis, sarcoidosis and a variety of other diseases with manifestations of disturbed immune balance.

References

Zhang, Yan, et al. "Novel thymopentin release systems prepared from bioresorbable PLA–PEG–PLA hydrogels." International journal of pharmaceutics 386.1 (2010): 15-22.
Gonser, S., E. Weber, and G. Folkers. "Peptides and polypeptides as modulators of the immune response: thymopentin—an example with unknown mode of action." Pharmaceutica Acta Helvetiae 73.6 (1999): 265-273.
Wang, Ying, et al. "Synthetic modifications of the immunomodulating peptide thymopentin to confer anti-mycobacterial activity." Biomaterials 35.9 (2014): 3102-3109.

Thymopentin Preparation Products And Raw materials

Raw materials

AMBERLITE(R) IRC-50 SEPHADEX G-75 ANION EXCHANGE RESIN 717

Preparation Products

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View Lastest Price from Thymopentin manufacturers

Sinoway Industrial co., ltd.
Product
Thymopentin 69558-55-0
Price
US $0.00/KG
Min. Order
2KG
Purity
99% up
Supply Ability
20tons
Release date
2022-08-24
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Thymopentin 69558-55-0
Price
US $0.00/g
Min. Order
1g
Purity
98%min
Supply Ability
1000g
Release date
2023-01-11
Shandong Huizhihan Supply Chain Co., Ltd
Product
Thymopentin (TP-5) 69558-55-0
Price
US $0.00-0.00/BOX
Min. Order
1BOX
Purity
99%
Supply Ability
20T
Release date
2024-11-12

69558-55-0, ThymopentinRelated Search:

THYMOPOIETIN II (33-36) Thymosin α1 Thymosin beta 4 Sermorelin Nesiritide acetate Triptorelin acetate Pramlintide acetate GLP-1 (7-37) Eptifibatide Thymalfasin THYMOPENTIN 5,THYMOPOIETIN PENTAPEPTIDE,ARG-LYS-ASP-VAL-TYR,arg-lys-asp-val-tyr acetate,H-ARG-LYS-ASP-VAL-TYR-OH THYMOPOIETIN II (32-35) THYMOPOIETIN II (32-34) THYMOPOIETIN II (34-36) THYMOSIN BETA10 (HUMAN, RAT) GLY-GLU-GLN-ARG-LYS-ASP-VAL-TYR-VAL-GLN-LEU-TYR-LEU H-ARG-LYS-ASP-VAL-TYR-OET,ARG-LYS-ASP-VAL-TYR-OET H-SER-ASP-ALA-ALA-VAL-ASP-THR-SER-SER-GLU-ILE-THR-THR-LYS-ASP-LEU-LYS-GLU-LYS-LYS-GLU-VAL-VAL-GLU-GLU-ALA-GLU-ASN-OH

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  • BioChemical
  • Amino Acids and Peptides
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