Thymalfasin
- Product Name
- Thymalfasin
- CAS No.
- 69440-99-9
- Chemical Name
- Thymalfasin
- Synonyms
- PubChem ID: 16130571;Thymalfasin;Thymalfansin;Thymosin alpha1 (ox);Thymosin α1 (cattle);The thymus method sheen;Thymosin alpha1 (human);Thymosin alpha1 (cattle);ThymalfasinQ: What is Thymalfasin Q: What is the CAS Number of Thymalfasin Q: What is the storage condition of Thymalfasin Q: What are the applications of Thymalfasin;L-Asparagine, N-acetyl-L-seryl-L-alpha-aspartyl-L-alanyl-L-alanyl-L-valyl-L-alpha-asparatyl-L-threonyl-L-seryl-L-seryl-L-alpha-glutamyl-L-isoleucyl-L-threonyl-L-threonyl-L-lysyl-L-alpha-aspartyl-L-leucyl-L-lysyl-L-alpha-glutamyl-L-lysyl-L-lysyl-L-alpha-glutamyl-L-valyl-L-valyl-L-alpha-glutamyl-L-alpha-glutamyl-L-alanyl-L-alpha-glutamyl-
- CBNumber
- CB01402515
- Molecular Formula
- C129H215N33O55
- Formula Weight
- 0
- MOL File
- Mol file
N-Bromosuccinimide Price
- Product number
- orb611695
- Product name
- Thymalfasin
- Packaging
- 1mg
- Price
- $345.1
- Updated
- 2021/12/16
- Product number
- orb611695
- Product name
- Thymalfasin
- Packaging
- 5mg
- Price
- $603.5
- Updated
- 2021/12/16
- Product number
- orb611695
- Product name
- Thymalfasin
- Packaging
- 10mg
- Price
- $1043.8
- Updated
- 2021/12/16
Thymalfasin Chemical Properties,Usage,Production
Uses
Zadax- in (SciClone).
Uses
Chronic hepatitis B and Chronic hepatitis C
Uses
Thymalfasin is an important peptide drug widely used for the single or combination treatment of hepatitis, sepsis, cancer, and immunodeficiency.
Definition
ChEBI: Thymalfasin is a polypeptide.
brand name
Zadaxin
Biological Functions
Thymalfasin is a 28-amino acid peptide with immunomodulatory activity that has demonstrated therapeutic potential in a variety of diseases, including viral hepatitis. It enhances T-cell function, exhibits antiviral activity and increases intracellular glutathione levels. This is primarily manifested in its ability to promote T-cell differentiation and/or maturation, increase the production of interferon-gamma (IFN-γ), IL-2 and IL-3, enhance natural killer (NK) cell activity, and promote the production of migration inhibitory factor (MIF). In vitro studies indicate that it counteracts T-cell apoptosis in thymocytes. Its antiviral action involves inhibiting viral replication by increasing the expression of MHC class I molecules and reducing viral replication in infected cells cultured in vitro. Thymalfasin also elevates intracellular glutathione levels, and this increase in glutathione is crucial for significantly reducing viral replication[1].
General Description
Thymalfasin (thymosin-alpha 1) is an immunomodulating agent able to enhance the Thl immune response. It has been evaluated for its immunomodulatory activities and related therapeutic potential in several diseases, including chronic hepatitis B and C, AIDS, primary immunodeficiency diseases, depressed response to vaccination and cancer.
Mechanism of action
The primary mechanism by which Thymalfasin operates involves bolstering the immune system. Thymosin Alpha-1, the active component of Thymalfasin, is known to enhance T-cell function. T-cells are a type of white blood cell crucial for adaptive immunity. By promoting the maturation and differentiation of these cells, Thymalfasin aids the body in mounting a more effective immune response against pathogens and malignant cells. Additionally, Thymalfasin has been observed to increase the production of various cytokines, including interleukin-2 (IL-2) and interferon-gamma (IFN-γ). These cytokines play a pivotal role in regulating immune responses and activating other immune cells. Furthermore, Thymalfasin has demonstrated the ability to enhance the activity of natural killer (NK) cells, which are essential for the innate immune response against virally infected cells and tumors. The peptide also exhibits anti-inflammatory properties, making it a multifaceted tool in the arsenal of immunotherapy.
References
[1] A. Ciancio, & M. R. (2010). Thymalfasin in the treatment of hepatitis B and C. Annals of the New York Academy of Sciences, 1194 1, 141–146. https://doi.org/10.1111/j.1749-6632.2010.05487.x
Thymalfasin Preparation Products And Raw materials
Raw materials
Preparation Products
Thymalfasin Suppliers
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View Lastest Price from Thymalfasin manufacturers
- Product
- Thymalfasin 69440-99-9
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000kgs
- Release date
- 2026-04-09
- Product
- Thymalfasin 69440-99-9
- Price
- US $36.00/BOX
- Min. Order
- 1BOX
- Purity
- 99.9
- Supply Ability
- 9999
- Release date
- 2026-03-02
- Product
- Thymalfasin 69440-99-9
- Price
- US $1.00/g
- Min. Order
- 10g
- Purity
- 99
- Supply Ability
- 999
- Release date
- 2025-09-22