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PROXYPHYLLINE

Product Name
PROXYPHYLLINE
CAS No.
603-00-9
Chemical Name
PROXYPHYLLINE
Synonyms
MT;7-(2-Hydroxypropyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione;Spasmolysin;PROXYPHYLINE;Thean;Theon;Brontyl;Spantin;Theoden;Sigophyl
CBNumber
CB7492824
Molecular Formula
C10H14N4O3
Formula Weight
238.24
MOL File
603-00-9.mol
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PROXYPHYLLINE Property

Melting point:
134-136°C
Boiling point:
487.2±51.0 °C(Predicted)
Density 
1.46±0.1 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
pka
14.55±0.20(Predicted)
form 
Solid
color 
White to Off-White
Water Solubility 
285.7g/L(temperature not stated)
Merck 
14,7905
InChI
InChI=1S/C10H14N4O3/c1-6(15)4-14-5-11-8-7(14)9(16)13(3)10(17)12(8)2/h5-6,15H,4H2,1-3H3
InChIKey
KYHQZNGJUGFTGR-UHFFFAOYSA-N
SMILES
N1(CC(O)C)C2=C(N(C)C(=O)N(C)C2=O)N=C1
CAS DataBase Reference
603-00-9(CAS DataBase Reference)
NIST Chemistry Reference
Proxyphylline(603-00-9)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
36
WGK Germany 
3
RTECS 
XH5907500
HS Code 
2939.59.0000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S351288
Product name
7-(2-HYDROXYPROPYL)THEOPHYLLINE
Purity
Aldrich
Packaging
1g
Price
$179
Updated
2024/03/01
Sigma-Aldrich
Product number
P3800000
Product name
Proxyphylline
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
p3800000
Price
$220
Updated
2024/03/01
TCI Chemical
Product number
H1430
Product name
7-(2-Hydroxypropyl)theophylline
Purity
>98.0%(HPLC)(N)
Packaging
5g
Price
$78
Updated
2024/03/01
TCI Chemical
Product number
H1430
Product name
7-(2-Hydroxypropyl)theophylline
Purity
>98.0%(HPLC)(N)
Packaging
25g
Price
$196
Updated
2024/03/01
Cayman Chemical
Product number
20937
Product name
Proxyphylline
Purity
≥98%
Packaging
500mg
Price
$49
Updated
2024/03/01
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PROXYPHYLLINE Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

A metabolite of Theophylline in human plasma.

Definition

ChEBI: Proxyphylline is an oxopurine.

Biological Activity

ki: 82 nm for bovine brain a1 adenosine receptorproxyphylline is an a1 adenosine receptor antagonist.the a1 adenosine receptor, the best characterized purinergic receptor family, can mediate responses via multiple pertussis toxin-sensitive gtp binding proteins to various different effectors.

in vitro

previous study showed that proxyphylline could selectively antagonize a1 adenosine receptors versus a2 adenosine receptors (ki = 850 μm for platelets) [1].

in vivo

in a previous study, rats that were allodynic following the vincristine injections were randomly allocated into four groups. theoesberiven f (a combination of proxyphylline and melilotus extract) was administered to rats. results showed that the decreased paw withdrawal threshold induced by vincristine injection was increased by theoesberiven f treatment and the increased withdrawal frequency to cold stimuli was also reduced by theoesberiven f treatment [2].

Purification Methods

Crystallise it from EtOH, aqueous MeOH or EtOAc. Roth Archiv Pharmazie 292 234 1959, Zelnik et al. Bull Soc Chim Fr 1733 1956, Beilstein 26 III/IV 2366.]

References

[1] u. schwabe, d. ukena and m. j. lohse. xanthine derivatives as antagonists at a1 and a2 adenosine receptors. naunyn-schmiedeberg's arch.pharmacol. 330,212-221 (1985).
[2] s. bang, y. s. kim and s. r. jeong. anti-allodynic effect of theoesberiven f in a vincristine-induced neuropathy model. exp. ther. med. 12(2), 799-803 (2016).
[3] selvig k. pharmacokinetics of proxyphylline in adults after intravenous and oral administration. eur j clin pharmacol. 1981 jan;19(2):149-55.

PROXYPHYLLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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PROXYPHYLLINE Suppliers

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View Lastest Price from PROXYPHYLLINE manufacturers

Wuhan Han Sheng New Material Technology Co.，Ltd
Product
Proxyphylline BP 603-00-9
Price
US $35.65/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2023-11-24
Wuhan Han Sheng New Material Technology Co.，Ltd
Product
Proxyphylline or 7-(2-Hydroxypropyl) Theophylline) 603-00-9
Price
US $35.66/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2023-11-24
Wuhan Han Sheng New Material Technology Co.，Ltd
Product
Monophylline, Spasmolysin 603-00-9
Price
US $35.67/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2023-11-24

603-00-9, PROXYPHYLLINERelated Search:

Diprophylline diniprofylline Tazifylline Xanthinol nicotinate PROXYPHYLLINE Theophylline Xanthinol 1,3-DIMETHYL-7-(OXIRAN-2-YLMETHYL)-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE (S)-Proxyphylline (R)-Proxyphylline Xantifibrate 8-CHLORO-7-(3-CHLORO-2-HYDROXYPROPYL)-1,3-DIMETHYL-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE 7-(3-CHLORO-2-HYDROXYPROPYL)-1,3-DIMETHYL-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE 8-BROMO-7-(2-HYDROXYPROPYL)-1,3-DIMETHYL-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE 8-BROMO-7-(3-CHLORO-2-HYDROXYPROPYL)-1,3-DIMETHYL-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE 1,3-DIMETHYL-8-MORPHOLINO-7-(2-OXIRANYLMETHYL)-2,3,6,7-TETRAHYDRO-1H-2,6-PURINEDIONE 8-BROMO-7-(2-HYDROXYBUTYL)-1,3-DIMETHYL-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE 8-(BENZYLAMINO)-7-(3-CHLORO-2-HYDROXYPROPYL)-1,3-DIMETHYL-2,3,6,7-TETRAHYDRO-1H-2,6-PURINEDIONE

  • Monophylline, Spasmolysin
  • Proxyphylline or 7-(2-Hydroxypropyl) Theophylline)
  • Diprophylline Impurity 4（Diprophylline EP Impurity D）
  • 7-(BETA-HYDROXYPROPYL)THEOPHYLLINE
  • [1,3-DIMETHYL-7-(2-HYDROXYPROPYL)-2,6-DIOXOPURINE]
  • 7-(B-hydroxypropyl)theophylline
  • Proxylphylline
  • Proxyphylline BP
  • 1H-Purine-2,6-dione, 3,7-dihydro-7-(2-hydroxypropyl)-1,3-dimethyl- (9CI)
  • 2,6-Dioxo-3,7-dihydro-7-(2-hydroxypropyl)-1,3-dimethylpurine
  • 7-(b-Hydroxypropyl)-1,3-dimethylxanthine
  • 7-(2-hydroxypropyl)-theophyllin
  • 7-(2-Hydroxypropyl)theophylline
  • 7-(beta-Hydroxypropyl)-1,3-dimethylxanthine
  • beta-Hydroxypropyltheophylline
  • beta-Oxypropyltheophyllin
  • Brontyl
  • Hydroxypropyltheophylline
  • Monophylline
  • MT
  • Oxypropyltheophylline
  • Proxiphylline
  • Proxy-Retardoral
  • Purophyllin
  • Sanwaphyllin
  • Sigophyl
  • Spantin
  • Spasmolysin
  • Thean
  • Theoden
  • Theon
  • Theophylline, 7-(2-hydroxypropyl)-
  • PROXYPHYLINE
  • PROXYPHYLLIN
  • PROXYPHYLLINE
  • Diprophylline EP Impurity D
  • 1,3-Dimethyl-7-(2-hydroxypropyl)xanthine
  • 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-7-(2-hydroxypropyl)-
  • 1H-Purine-2,6-dione, 3,7-dihydro-7-(2-hydroxypropyl)-1,3-dimethyl-
  • 2-Hydroxypropyl-7-theophylline
  • 3,7-dihydro-1,3-dimethyl-7-(2-hydroxypropyl)-1h-purine-6-dione
  • 3,7-Dihydro-7-(2-hydroxypropyl)-1,3-dimethyl-1H-purine-2,6-dione
  • 3,7-dihydro-7-(2-hydroxypropyl)-1,3-dimethyl-1h-purine-6-dione
  • 7-(2-Hydroxypropyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione
  • b-Hydroxypropyltheophylline
  • NSC 163343
  • Theophylline, 7-(2-hydroxypropyl)- (6CI, 7CI, 8CI)
  • 7-(BETA-HYDROXYPROPYL)-THEOPHYLLINE 99% BP2003
  • (1,3-Dimethyl-7-[2-hydroxypropyl]-2,6-dioxopurine), Proxyphylline
  • 7-(2-hydroxypropyl)-1,3-dimethyl-purine-2,6-dione
  • 7-(2-hydroxypropyl)-1,3-dimethylpurine-2,6-dione
  • 7-(2-hydroxypropyl)-1,3-dimethyl-xanthine
  • 7-(2-Hydroxypropyl)-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione
  • 7-(2-Hydroxypropyl)theophylline&gt
  • Proxyphylline CRS
  • 7-(β-Hydroxypropyl)theophylline
  • Pentoxifylline Impurity 1
  • 7-[(2RS)-2-hydroxypropyl]-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione (proxyphylline).