PD 146176

Product Name: PD 146176
CAS No.: 4079-26-9
Chemical Name: PD 146176
Synonyms: NSC168807;PD146176 (NSC168807);6,11-dihydrothiochromeno[4,3-b]indole;[1]Benzothiopyrano[4,3-b]indole, 6,11-dihydro-;inhibit,tau,brain,triple,NSC-168807,PD146176,Autophagy,pathology,amyloidosis,transgenic,reticulocyte,impairment,cognitive,mice,NSC 168807,Inhibitor,cells,PD 146176,IC21,PD-146176,rabbit,Ferroptosis
CBNumber: CB7504219
Molecular Formula: C15H11NS
Formula Weight: 237.32
MOL File: 4079-26-9.mol

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PD 146176 Property

Melting point:: 160 °C
Boiling point:: 485.4±24.0 °C(Predicted)
Density: 1.333±0.06 g/cm3(Predicted)
storage temp.: Store at +4°C
solubility: DMSO: 16 mg/mL, soluble
form: solid
pka: 16.17±0.20(Predicted)
color: cream-colored

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Safety

Safety Statements: 22-24/25
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P4620
Product name: PD 146176
Purity: ≥98% (HPLC), solid
Packaging: 5mg
Price: $201
Updated: 2024/03/01

Sigma-Aldrich

Product number: P4620
Product name: PD 146176
Purity: ≥98% (HPLC), solid
Packaging: 25mg
Price: $636
Updated: 2024/03/01

Cayman Chemical

Product number: 10010518
Product name: PD 146176
Purity: ≥98%
Packaging: 5mg
Price: $48
Updated: 2024/03/01

Cayman Chemical

Product number: 10010518
Product name: PD 146176
Purity: ≥98%
Packaging: 10mg
Price: $89
Updated: 2024/03/01

Cayman Chemical

Product number: 10010518
Product name: PD 146176
Purity: ≥98%
Packaging: 25mg
Price: $210
Updated: 2024/03/01

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PD 146176 Chemical Properties,Usage,Production

Description

PD 146176 is a potent and selective inhibitor of reticulocyte 15-lipoxygenase-1. It limits hypercholesterolemia-induced atherosclerosis in New Zealand White rabbits and reduces oxidant stress-induced apoptosis in endothelial cells. PD 146176 inhibits amyloid β protein aggregate formation without changing total levels of amyloid β precursor protein (APP) in cells stably expressing APP. In addition, it lacks significant non-specific antioxidant properties.

Uses

PD 146176 has been used to study its influence on ex vivo leukotriene B4 (LTB4) and lipoxin A4 (LXA4) secretion in adipose tissue.

Definition

ChEBI: PD-146176 is an organic heterotetracyclic compound that is 1H-indole which is ortho-fused to a 2H-1-benzothiopyran group at positions 2-3. It is an inhibitor of 15-lipoxygenase that limits atherosclerotic lesion development in rabbits. It has a role as a ferroptosis inhibitor, an EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor and an antiatherogenic agent. It is an organic heterotetracyclic compound, an organosulfur heterocyclic compound and an organonitrogen heterocyclic compound.

Biological Activity

Specific, non-competitve 15-lipoxygenase (15-LOX) inhibitor (K i = 197nM) that has no demonstrable effect on 5-LOX, 12-LOX, COX-1 or COX-2 (IC 50 = 0.54 μ M for 15-LOX in rabbit reticulocytes). Lacks non-specific antioxidant properties and prevents atherogenesis via regulation of monocyte-macrophage enrichment in vivo .

Biochem/physiol Actions

PD 146176 blocks neuroprotectin D1 (NPD1) and eicosanoid synthesis by inhibiting the 5-lipoxygenase-1 (15-LOX-1) enzyme.

storage

Store at +4°C

PD 146176 Preparation Products And Raw materials

Raw materials

Preparation Products

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PD 146176 Suppliers

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View Lastest Price from PD 146176 manufacturers

Career Henan Chemical Co

Product: 6,11-Dihydrothiochromeno[4,3-b]indole 4079-26-9
Price: US $2.00/KG
Min. Order: 1KG
Purity: ≥98%
Supply Ability: 20 tons
Release date: 2019-12-27

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6,11-dihydrothiochromeno[4,3-b]indole

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PD146176 (NSC168807)

NSC168807

inhibit,tau,brain,triple,NSC-168807,PD146176,Autophagy,pathology,amyloidosis,transgenic,reticulocyte,impairment,cognitive,mice,NSC 168807,Inhibitor,cells,PD 146176,IC21,PD-146176,rabbit,Ferroptosis

4079-26-9