ChemicalBook > CAS DataBase List > PD 146176

PD 146176

Product Name
PD 146176
CAS No.
4079-26-9
Chemical Name
PD 146176
Synonyms
PD 146176;NSC168807;PD146176 (NSC168807);6,11-dihydrothiochromeno[4,3-b]indole;[1]Benzothiopyrano[4,3-b]indole, 6,11-dihydro-;inhibit,tau,brain,triple,NSC-168807,PD146176,Autophagy,pathology,amyloidosis,transgenic,reticulocyte,impairment,cognitive,mice,NSC 168807,Inhibitor,cells,PD 146176,IC21,PD-146176,rabbit,Ferroptosis
CBNumber
CB7504219
Molecular Formula
C15H11NS
Formula Weight
237.32
MOL File
4079-26-9.mol
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PD 146176 Property

Melting point:
160 °C
Boiling point:
485.4±24.0 °C(Predicted)
Density 
1.333±0.06 g/cm3(Predicted)
storage temp. 
Store at +4°C
solubility 
DMSO: 16 mg/mL, soluble
form 
solid
pka
16.17±0.20(Predicted)
color 
cream-colored
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P4620
Product name
PD 146176
Purity
≥98% (HPLC), solid
Packaging
5mg
Price
$201
Updated
2024/03/01
Sigma-Aldrich
Product number
P4620
Product name
PD 146176
Purity
≥98% (HPLC), solid
Packaging
25mg
Price
$636
Updated
2024/03/01
Cayman Chemical
Product number
10010518
Product name
PD 146176
Purity
≥98%
Packaging
5mg
Price
$48
Updated
2024/03/01
Cayman Chemical
Product number
10010518
Product name
PD 146176
Purity
≥98%
Packaging
10mg
Price
$89
Updated
2024/03/01
Cayman Chemical
Product number
10010518
Product name
PD 146176
Purity
≥98%
Packaging
25mg
Price
$210
Updated
2024/03/01
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PD 146176 Chemical Properties,Usage,Production

Description

PD 146176 is a potent and selective inhibitor of reticulocyte 15-lipoxygenase-1. It limits hypercholesterolemia-induced atherosclerosis in New Zealand White rabbits and reduces oxidant stress-induced apoptosis in endothelial cells. PD 146176 inhibits amyloid β protein aggregate formation without changing total levels of amyloid β precursor protein (APP) in cells stably expressing APP. In addition, it lacks significant non-specific antioxidant properties.

Uses

PD 146176 has been used to study its influence on ex vivo leukotriene B4 (LTB4) and lipoxin A4 (LXA4) secretion in adipose tissue.

Definition

ChEBI: PD-146176 is an organic heterotetracyclic compound that is 1H-indole which is ortho-fused to a 2H-1-benzothiopyran group at positions 2-3. It is an inhibitor of 15-lipoxygenase that limits atherosclerotic lesion development in rabbits. It has a role as a ferroptosis inhibitor, an EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor and an antiatherogenic agent. It is an organic heterotetracyclic compound, an organosulfur heterocyclic compound and an organonitrogen heterocyclic compound.

Biological Activity

Specific, non-competitve 15-lipoxygenase (15-LOX) inhibitor (K i = 197nM) that has no demonstrable effect on 5-LOX, 12-LOX, COX-1 or COX-2 (IC 50 = 0.54 μ M for 15-LOX in rabbit reticulocytes). Lacks non-specific antioxidant properties and prevents atherogenesis via regulation of monocyte-macrophage enrichment in vivo .

Biochem/physiol Actions

PD 146176 blocks neuroprotectin D1 (NPD1) and eicosanoid synthesis by inhibiting the 5-lipoxygenase-1 (15-LOX-1) enzyme.

storage

Store at +4°C

PD 146176 Preparation Products And Raw materials

Raw materials

Preparation Products

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PD 146176 Suppliers

Biomol Feinchemikalien GmbH
Tel
--
Fax
--
Email
info@biomol.de
Country
Germany
ProdList
479
Advantage
74
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View Lastest Price from PD 146176 manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
PD 146176 4079-26-9
Price
US $30.00-20.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200000KG
Release date
2024-07-31
Career Henan Chemical Co
Product
6,11-Dihydrothiochromeno[4,3-b]indole 4079-26-9
Price
US $2.00/KG
Min. Order
1KG
Purity
≥98%
Supply Ability
20 tons
Release date
2019-12-27

4079-26-9, PD 146176Related Search:


  • 6,11-dihydrothiochromeno[4,3-b]indole
  • [1]Benzothiopyrano[4,3-b]indole, 6,11-dihydro-
  • PD146176 (NSC168807)
  • NSC168807
  • inhibit,tau,brain,triple,NSC-168807,PD146176,Autophagy,pathology,amyloidosis,transgenic,reticulocyte,impairment,cognitive,mice,NSC 168807,Inhibitor,cells,PD 146176,IC21,PD-146176,rabbit,Ferroptosis
  • PD 146176
  • 4079-26-9